Thursday 16 October, 2025
Objectives: Dexmedetomidine is a selective alpha2-adrenoreceptor agonist used for sedation in critically ill patients. The aim of this study was…
Read morePoster: Applications- CNS
Predictive performance of two PK-PD models of D2 receptor occupancy of the antipsychotics risperidone and paliperidone in rats
Thursday 16 October, 2025
Objectives: The level of dopamine D2 receptor occupancy is predictive of efficacy and safety in schizophrenia. Population PK-PD modelling has…
Read morePlasma and Cerebrospinal Fluid Pharmacokinetics of Naproxen in Children
Thursday 16 October, 2025
Objectives: There has recently been interest in the mechanism of action of NSAIDs in CNS. We evaluated the cerebrospinal fluid…
Read moreCSF and Plasma Pharmacokinetics of Flurbiprofen in Children
Thursday 16 October, 2025
Objectives: There has recently been interest in mechanism of action of NSAIDs in CNS. We have evaluated the CNS penetration…
Read morePopulation pharmacokinetics and pharmacodynamics of Propofol in morbidly obese patients
Thursday 16 October, 2025
Objectives: The number of morbidly obese patients (Body Mass Index (BMI) > 40 kg.m-2) undergoing (weight-reducing) surgery increases. However, the…
Read moreModeling and Simulation of Placebo Response and Dropout Patterns in Treatment of Schizophrenia
Thursday 16 October, 2025
Objectives: Unpredictable variation in placebo response within and among clinical trials can substantially affect conclusions about the efficacy of new…
Read morePopulation Pharmacokinetics of Carbamazepine and Estimation of Influencing Factors
Thursday 16 October, 2025
Objectives: Carbamazepine (CBZ) is an effective anticonvulsant for partial and generalized seizures in both adults and children. Because of a…
Read moreExtended Link Model to Describe the Impact of Chronic Antiepileptic Therapy on the Effects of Neuromuscular Blocking Agents.
Thursday 16 October, 2025
Objectives: Antiepileptic drugs decrease the intensity of the effect of most neuromuscular blocking agents (NMBA). Wright et al., 2004,[1] found that CL…
Read moreMultinomial logistic functions in Markov-chain models for modelling sleep architecture after placebo administration
Thursday 16 October, 2025
Objectives: The aim of this work was to generalize the previously proposed [1] mixed-effect Markov-chain model based on piecewise linear…
Read moreEstimation of cortical amyloid beta turnover rates
Thursday 16 October, 2025
Objectives: To estimate the turnover rate of cortical amyloid beta (Aβ) in a non-transgenic preclinical mouse model and to compare…
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