Thursday 16 October, 2025
PDF of presentation Introduction: Gene therapy seen as a tool for drug delivery implies accessibility to the site of action,…
Read moreoral presentation
A comparison of estimation methods in nonlinear mixed effects models using a blind analysis
Thursday 16 October, 2025
PDF of presentation Background: In 1994, a blind evaluation of several estimation algorithms on one population PK simulated data set…
Read moreModel Evaluation
Thursday 16 October, 2025
Model evaluation, or the more stronger term, model validation can be defined as the objective assessment of the predictive performance…
Read morePK extrapolation from animal to man: the good, the bad and the ugly. An overview of the performance of different methods applied across the project portfolio at Roche
Thursday 16 October, 2025
Background: In order to reduce failures related to pharmacokinetic (PK) issues and to determine the suitability of compounds for an…
Read moreOptimisation Of Individual And Population Pharmacokinetic Designs Using S-Plus
Thursday 16 October, 2025
An approach based on the Fisher information matrix for non linear mixed effects models, implemented in a generic Splus function…
Read moreThe Population Approach Identity Crisis: The Search For Innovation In Modeling And Simulation
Thursday 16 October, 2025
PDF of presentation Unambiguously defining ‘innovation’ in modelling and simulation of biomedical systems, especially pharmacokinetic and pharmacodynamic systems, has been…
Read moreIncorporating uncertainty and variability into PBPK based predictions of human PK
Thursday 16 October, 2025
PDF of presentation Background: PBPK (physiologically based pharmacokinetic) models are used in preclinical research to predict drug concentrations in plasma…
Read moreDealing With Missing Data Through Random Effects Models
Thursday 16 October, 2025
A standard clinical trial assigns treatments A, observes outcomes Y, and, generically, uses the disparity between the goodness of fit…
Read moreMixture Modelling for the Detection of Subpopulations in a Pharmacokinetic/Pharmacodynamic analysis
Thursday 16 October, 2025
PDF of presentation Introduction and Objectives: To be able to estimate accurately parameters entering a nonlinear mixed effect model using…
Read morePKPD Workshop ‘An overview on how to use NONMEM for PKPD analyses’
Thursday 16 October, 2025
A lunchtime workshop held at PAGE Pamplona 2005 intended for NONMEM users who have at least a little experience with…
Read more