Thursday 16 October, 2025
Objective: To describe the pregabalin exposure-adverse event (dizziness and somnolence) relationship following pregabalin doses in patients with neuropathic pain, generalized…
Read moreoral presentation
Population pharmacokinetics and pharmacodynamics of enoxaparin in obese patients
Thursday 16 October, 2025
Background Enoxaparin dosing is currently based on total body weight. It is not known how to dose adjust patients who…
Read moreBayesian Optimal Design for the Study of Butadiene Toxicokinetics
Thursday 16 October, 2025
As a following of the paper ‘Optimal design for a study of butadiene toxicokinetics in humans’ (Bois and Smith, Toxicol…
Read moreHistory and new developments in estimation methods in nonlinear mixed-effects models
Thursday 16 October, 2025
PDF of presentation NONMEM software, which included FO and then FOCE methods, was developed in the late 70’s before statistician…
Read moreBayesian analysis of a patient dataset using prior information from normal volunteers and from another patient group
Thursday 16 October, 2025
PDF of presentation In drug development, researchers have been using available information for designing trials, analysing data and, ultimately, making…
Read moreNONMEM Implementation of Cell Lifespan Models for Hematological Drug Effects
Thursday 16 October, 2025
PDF of presentation Different PK/PD models for dealing with the hematological drug effects have been recently published in the literature…
Read moreRegulatory aspects of population pharmacokinetic drug interaction studies
Thursday 16 October, 2025
Information on drug-drug interactions is generally gathered form conventional Phase I studies in healthy volunteers, but information is also generated…
Read moreAssessing the Additivity of the Effects of Drugs in Mixtures
Thursday 16 October, 2025
A general statistical model to assess the effects of combinations of any number of drugs is presented. The model is…
Read moreDealing with Autoinhibition of Drug Clearance in Early Clinical Product Development
Thursday 16 October, 2025
Complexities related with drug clearance such as drug-drug interactions, autoinhibition/induction, genetic polymorphism, dose-dependency, etc, are major issues that sometimes can…
Read morePharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in the Paediatric Population
Thursday 16 October, 2025
PDF of presentation Introduction: The metabolite O-demethyltramadol (M1) is the main responsible for the analgesia after administration of tramadol (T)….
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