Thursday 16 October, 2025
Objectives: A patient population is usually heterogeneous with respect to response to drug therapy. In any clinical efficacy trial, patients…
Read moreOral Presentation: Methodology
Optimal Design to Estimate the Time Varying Receptor Occupancy Relationship in a PET Experiment
Thursday 16 October, 2025
Objectives: Positron emission tomography (PET) is one of the most effective imaging techniques used to investigate ligand-receptor binding in living…
Read moreMonte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/ Pharmacodynamic (PK/PD) Data
Thursday 16 October, 2025
Objectives: A new method for population PK/PD, based on statistical theory, has been developed and implemented in two different programs (PDx-MC-PEM…
Read moreThe LASSO – A Novel Method for Predictive Covariate Model Building in Nonlinear Mixed Effects Models
Thursday 16 October, 2025
PDF of presentation Introduction: Covariate models for population Pharmacokinetics (PK) and Pharmacodynamics (PD) are often built with stepwise-covariate-selection procedures such…
Read moreSoftware for optimal design in population pharmacokinetics and pharmacodynamics: a comparison
Thursday 16 October, 2025
Introduction: Following the first theoretical work on optimal design for nonlinear mixed effect models, this research theme has rapidly grown…
Read moreThe challenge of modelling hepatitis C virus dynamics after long term treatment: Application of MONOLIX
Thursday 16 October, 2025
Background: Mathematical models for hepatitis C viral (HCV) RNA kinetics have provided important insights into the life cycle of HCV…
Read moreDesign optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics
Thursday 16 October, 2025
Objectives: We recently extended the R function PFIM [1] for population design evaluation and optimisation to deal with multiple response…
Read moreThe Influence of the Time Course of CD4 and Viral Load on Clinical Outcome Events Before and During Antiretroviral Therapy
Thursday 16 October, 2025
Objectives:Â Mechanistic mixed effect models for HIV infection using CD4 cell counts and viral load (VL) are only practical for…
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