Thursday 16 October, 2025
Objectives: Previously an intensive sampling schedule spread over 2 days was used to identify the pre-transplantation oral (PO) and intravenous…
Read moreOral Presentation: Methodology
Sequential versus simultaneous optimal experimental design on dose and sample times
Thursday 16 October, 2025
Background: To increase the efficiency of trials in drug development, optimal experimental design has been used to optimize the sampling…
Read moreAnalysis Approaches Handling Both Symptomatic Severity and Frequency
Thursday 16 October, 2025
Background Graded events analyses are often accompanied with a loss of information by not handling the true nature of the…
Read moreEvaluating the IPPSE method for PKPD analysis
Thursday 16 October, 2025
Background: To develop PKPD models based on previously determined individual PK parameter (IPP) estimates is a common alternative to the simultaneous…
Read moreModel-based tests to detect gene effect in pharmacokinetic studies
Thursday 16 October, 2025
Introduction Pharmacogenetics studies the relationship between the interindividual variability and variations in DNA sequence of proteins involved in mechanisms of…
Read moreExtending the Latent Variable Model to Non-Independent Longitudinal Dichotomous Response Data
Thursday 16 October, 2025
Background: Sheiner and Sheiner et. al. brought attention to generalized nonlinear mixed effects modeling of ordered categorical data, and the…
Read moreEstimating Transformations for Population Models of Continuous, Closed Interval Data
Thursday 16 October, 2025
Objectives: The Stanford Health Assessment Questionnaire Disability Index (HAQ-DI) is a self reported tool used in rheumatoid diseases. These clinical…
Read moreA new exact test to globally assess a population PK and/or PD model
Thursday 16 October, 2025
Objectives: Standardised predictions errors are provided by most software (WRES in NONMEM; PWRES in MONOLIX) and are widely used as…
Read moreA flexible approach to modeling variable absorption in the context of repeated dosing: illustrated with rifampicin
Thursday 16 October, 2025
Introduction and Objectives: A flexible transit compartment absorption model (TCAM), in which a delay in the onset of absorption and…
Read moreA new SAEM algorithm for ordered-categorical and count data models: implementation and evaluation
Thursday 16 October, 2025
Objectives: Analysis of categorical and count data from clinical trials using mixed effect analysis has recently become the method of…
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