Thursday 16 October, 2025
PDF of presentation Objectives: Extension of a disease model describing the regulation of the glucose-insulin system after an intravenous glucose…
Read moreOral Presentation: Lewis Sheiner Student Session
Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics and Estimation: Problems and Solutions
Thursday 16 October, 2025
Introduction: Empirical Bayes estimates (EBEs), known also as POSTHOC estimates, provide modelers with individual-specific values, such as individual predictions (IPRED),…
Read moreSemi-mechanistic PK/PD model of indisulam in combination with capecitabine: a time-dependent pharmacokinetic interaction contributes to excessive hematological toxicity
Thursday 16 October, 2025
PDF of presentationIntroduction Indisulam is an experimental sulfonamide anticancer agent which was evaluated in a phase I dose escalation study…
Read moreThe SAEM algorithm for non-linear mixed models with left-censored data and differential systems: application to the joint modeling of HIV viral load and CD4 dynamics under treatment
Thursday 16 October, 2025
PDF of presentationIntroduction Maximum likelihood estimation in non-linear mixed effects models cannot be performed directly since the likelihood has no…
Read moreA Study Comparing the Performance of the Proportional Odds Model to that of the Differential Drug Effect Model for Cumulative Logits
Thursday 16 October, 2025
PDF of presentation Introduction: In 1994, Lewis Sheiner proposed the use of the proportional odds model, a special case of…
Read moreNormalized Prediction Distribution Error for the Evaluation of Nonlinear Mixed-Models
Thursday 16 October, 2025
Introduction: Although population pharmacokinetic and/or pharmacodynamic model evaluation is recommended by regulatory authorities, there is no consensus today on the…
Read moreModelling the Dynamics of Glucose, Insulin, Insulin Sensitivity and Beta-Cells in Subjects with Insulin Resistance and Patients with Type 2 Diabetes
Thursday 16 October, 2025
Introduction: Type 2 diabetes mellitus (T2DM) is a progressive, metabolic disorder characterized by reduced insulin sensitivity (insulin resistance) and loss…
Read moreNon-linear mixed-effects models for tests of interaction or of lack of interaction in cross-over and parallel pharmacokinetic studies: application to the test of interaction between protease inhibitors and nucleoside analogs in HIV patients
Thursday 16 October, 2025
PDF of presentation Introduction: Pharmacokinetic (PK) interaction, or lack of interaction, of a drug B on a drug A, is…
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