Thursday 16 October, 2025
Background: Pregabalin (Lyrica®) is a voltage-gated calcium channel α2-δ ligand for the treatment of partial seizure, neuropathic pain and generalized…
Read moreOral Presentation: Lewis Sheiner Student Session
Estimation of mixed hidden Markov models with SAEM. Application to daily seizures data.
Thursday 16 October, 2025
Objectives: In some specific medical contexts, the values of biological markers at successive time points are the only informations available…
Read moreNovel graphical diagnostics for assessing fit of logistic regression models
Thursday 16 October, 2025
Background: Assessment of goodness of fit of a model to the data set is essential to ensure the model provides…
Read morePrediction of haematological effects of a new combination of anticancer drugs, BI 2536 (a PLK1 inhibitor) and pemetrexed, using a semi-mechanistic population model for neutropenia
Thursday 16 October, 2025
Background: BI 2536 is a inhibitor of Polo-like kinase 1 (Plk1) currently in clinical development. Plk1 plays an essential role…
Read moreTime Course of Disease Status as a Predictor of Clinical Outcome in Parkinson’s Disease
Thursday 16 October, 2025
Introduction: There are two reasons for studying the time course of disease status as a predictor in time to event…
Read moreDesign evaluation and optimisation in multi-response nonlinear mixed effect models with cost functions: application to the pharmacokinetics of zidovudine and its active metabolite
Thursday 16 October, 2025
Introduction: Models with multiple responses within patients are increasingly used in population analyses. Main examples are joint pharmacokinetic-pharmacodynamic models, complex…
Read moreNonparametric Methods: When to use them? Which method to choose?
Thursday 16 October, 2025
Background. Parametric methods, routinely used for population pharmacokinetics (PK) and/or pharmacodynamics (PD) analyses, rely on the normality of random effects…
Read moreModeling of gastro-intestinal tablet transit and its’ effect on drug release and absorption for felodipine extended release tablet under fed or fasting conditions
Thursday 16 October, 2025
Background: Magnetic Marker Monitoring is a novel technique for visualising the transit of a solid oral dosage form through the…
Read moreA KPD Model for ordered categorical data: application to toxicity score in colorectal cancer patients treated with capecitabine
Thursday 16 October, 2025
PDF of presentationIntroduction: Capecitabine is an oral fluropyrimidine carbamate, converted to 5-Fluorouracil (5FU) predominantly in tumour tissue, prescribed in the…
Read moreIdentifiability Analysis and Parameter List Reduction of a Nonlinear Cardiovascular PKPD Model
Thursday 16 October, 2025
Objective: Pharmacokinetic and pharmacodynamic modelling is becoming evermore sophisticated. Specifically there has been a drive to create more mechanistically relevant…
Read more