Thursday 16 October, 2025
Objectives: There is much interest in the application of machine learning (ML) algorithms for the personalisation of treatment. Nonlinear mixed-effects…
Read moreOral: Methodology - New Modelling Approaches
Copula modeling for realistic virtual patient covariate simulation
Thursday 16 October, 2025
Objectives: Simulation of virtual patients is a commonly applied procedure in pharmacometrics for optimizing dosing regimens and clinical trial simulation. For…
Read moreUse of item-based non-linear mixed effects model to improve confidence in Phase III clinical trial decision-making
Thursday 16 October, 2025
Introduction: The proportion of failed trials due to lack of efficacy is strikingly greater in Phase III clinical drug development…
Read moreDeep Learning for PK/PD and Disease Progression Time-Course Predictions using Neural-ODE
Thursday 16 October, 2025
Introduction: The modeling of pharmacokinetic/pharmacodynamic (PK/PD) and disease progression are currently performed using population approaches. However, the recent development of…
Read moreA novel score test-based method for efficient covariate selection in population pharmacokinetic analysis
Thursday 16 October, 2025
Objectives: Originally proposed Wald’s approximation method (WAM) [1], least absolute shrinkage and selection operator (LASSO) [2] and stepwise covariate method…
Read moreA systematic framework for the incorporation of preclinical species data into physiologically-based pharmacokinetic models using a middle-out approach to improve the translation of drug distribution in humans
Thursday 16 October, 2025
Objectives: Optimization of parameters in complex models, such as the whole-body physiologically-based pharmacokinetic (PBPK) model by model fitting to observed…
Read moreA cohesive model framework of receptor pharmacology: beyond the Emax model
Thursday 16 October, 2025
Background: Just over 150 years ago, the Norwegian mathematician Cato Guldberg and the chemist Peter Waage, propounded the law of…
Read moreModel Averaging in viral dynamic models
Thursday 16 October, 2025
Objectives: Nonlinear mixed effect models (NLMEM) are now becoming a central tool in viral dynamic models to estimate parameters of viral…
Read moreA partial differential equation approach to inhalation PBPK modelling
Thursday 16 October, 2025
Objectives: Inhalation pharmacokinetics (PK) is known to be vastly complex due to the spatial heterogeneity in lung physiology and the…
Read moreJoint modeling of overall survival and tumor size dynamics in non-small cell lung cancer: Clinical trial simulations and validation of predictions at study and subject levels
Thursday 16 October, 2025
Objectives: Projecting survival estimates from early- to late-phase studies is a critical step in anti-cancer drug development. Surrogate endpoints such as…
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