Thursday 16 October, 2025
Population pharmacokinetic (popPK) models are used in decision-making throughout drug development to inform dose selection, clinical study design, and labelling…
Read moreOral: Methodology - New Modelling Approaches
Meta-analysis of parameter estimates of non-linear mixed effect models using Approximate Bayesian Computation: application to population pharmacokinetics
Thursday 16 October, 2025
Introduction: Non-Linear Mixed Effect Models (NLMEM) are a gold standard tool to analyze pharmacokinetic (PK) data. Generally, numerous population PK…
Read moreBayesian framework for multi-source data integration – application to Human extrapolation from preclinical studies
Thursday 16 October, 2025
Introduction: In preclinical research, including in vitro studies (conducted within subcellular fractions, cell cultures, micro-organisms, organoid models, etc.), in vivo…
Read moreThe estimates for the absorption rate constant in pharmacokinetics and pharmacometrics are wrong: A new era based on the finite absorption time concept rises
Thursday 16 October, 2025
Introduction: Common practice in pharmacokinetic analyses and data evaluation as well as in simulations is based on the assumption that…
Read moreA methodology to de-shrink Empirical Bayes Estimates
Thursday 16 October, 2025
Objectives: Therapeutic drug monitoring (TDM) is used for some drugs to evaluate drugs exposures and optimize the therapeutic management of…
Read moreBenefits of integrating machine learning with clinical pharmacology principles for predictive pharmacokinetic modeling
Thursday 16 October, 2025
Introduction: Machine learning (ML) applications in clinical pharmacology have been rapidly increasing over the last several years (1). While most…
Read moreA Semi Parametric Method for the Estimation of End of Treatment Effect
Thursday 16 October, 2025
Objectives: End of treatment effect is a commonly used endpoint in Randomized Clinical Trials (RCTs). Several methods are used for…
Read moreThe Neural Mixed Effects algorithm: leveraging machine learning for pharmacokinetic modelling
Thursday 16 October, 2025
Objectives: There is much interest in the application of machine learning (ML) algorithms for the personalisation of treatment. Nonlinear mixed-effects…
Read moreA novel mathematical model of neurofilament trafficking in healthy subjects
Thursday 16 October, 2025
Objectives: Neurofilaments (NFs) are cytoskeletal proteins of the neurons present mainly in the axons. Following axonal injury, NFs are released…
Read moreDevelopment of a multilevel nonlinear joint model to characterize effect of tumor variability under immunotherapy
Thursday 16 October, 2025
Context: Immunotherapy showed impressive results in oncology in the past few years, but novel patterns of response complicate the association…
Read more