Program - PAGE Meeting (Population Approach Group Europe)

Tuesday

14:00-18:00	Registration at the conference venue


18:00-19:30	Welcome reception with drinks and light snacks (no dinner)


Wednesday

08:00-08:45	Registration at the conference venue


08:45-09:00	Welcome and introduction


09:00-09:45	Keynote lecture		Chair: Dinesh De Alwis

09:00-09:45	Jeff Sachs	Pharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics

09:45-09:50	PAGE scientific program		Siv Jonsson

09:50-11:15	Coffee break, poster and software session I: posters in Group I (with poster numbers starting with I-) are accompanied by their presenter


11:15-12:15	Infectious diseases		Chair: France Mentré

11:15-11:35	Marjorie Imperial	Stratified medicine approaches for drug susceptible tuberculosis patients

11:35-11:55	Stefanie Hennig	Repeated time-to-event models support that Pseudomonas aeruginosa infection increase the risk of acquiring Aspergillus in young children with cystic fibrosis

11:55-12:15	María García-Cremades	Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials

12:15-13:45	Lunch


13:45-14:30	Tutorial		Chair: Mats Karlsson

13:45-14:30	Nicky Best	Use of informative priors in model-informed drug development

14:30-15:10	Machine learning in oncology		Chairs: Mats Karlsson, Paolo Magni

14:30-14:50	Chiara Nicolò	Machine learning combined to mechanistic modeling of differential effects of neoadjuvant sunitinib on primary tumor and metastatic growth

14:50-15:10	Sebastien Benzekry	Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer

15:10-16:40	Coffee break, poster and software session I: posters in Group II (with poster numbers starting with II-) are accompanied by their presenter


16:40-16:45	Clinical pharmacometrics - ISoP special interest group		Mirjam Trame and Eva Germovsek

16:45-17:25	Clinical applications		Chair: Oscar Della Pasqua

16:45-17:05	João Abrantes	Bayesian forecasting utilizing bleeding information to support dose individualization of factor VIII

17:05-17:25	Belén Pérez Solans	Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning

17:25-18:05	Rare (and other) diseases		Chair: Panos Macheras

17:25-17:45	Zinnia Parra-Guillen	Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases

17:45-18:05	Pascal Chanu	A disease progression model for geographic atrophy

Thursday

08:30-09:45	Lewis Sheiner Student Session		Chair: Andrew Hooker, Emilie Hénin, Thomas Dorlo

08:30-08:55	Moustafa M. A. Ibrahim	Competing risks analysis of the Finnish diabetes prevention study

08:55-09:20	Sebastiaan Goulooze	Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children

09:20-09:45	Elena Tosca	Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset

09:45-09:50	Presentation LBS awards


09:50-09:55	Special announcement


09:55-11:20	Coffee break, poster and software session I: posters in Group III (with poster numbers starting with III-) are accompanied by their presenter


11:20-12:25	Regulatory model-informed drug discovery and development		Chair: Aris Dokoumetzidis

11:20-12:05	Kristin Karlsson	Regulatory model-informed drug discovery and development in EU – News flash and examples

12:05-12:25	Sylvie Retout	A model-based extrapolation enabled labelling of emicizumab in haemophilia A paediatric patients <1 year old despite lack of clinical data

12:25-12:30	ACoP Announcement


12:30-14:00	Lunch


12:30-14:00	ISoP Student Community meet-and-greet during lunch


14:00-15:20	Stuart Beal methodology session		Chair: Emmanuelle Comets and Siv Jönsson

14:00-14:20	Theodoros Papathanasiou	Model based optimization of dose-finding studies for drug-combinations.

14:20-14:40	Antonio Goncalves	Model Averaging in viral dynamic models

14:40-15:00	Mohammed Cherkaoui Rbati	A liver model for chemoprotection against malaria

15:00-15:20	Xiao Zhu	A cohesive model framework of receptor pharmacology: beyond the Emax model

15:20-15:25	WCoP Announcement


15:25-16:50	Coffee break, poster and software session I: posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter


16:50-17:30	Stuart Beal methodology session, continued		Chair: Justin Wilkins

16:50-17:10	Alison Margolskee	Exploratory graphics (xGx): promoting the purposeful exploration of PKPD data

17:10-17:30	Marc Cerou	Performance of npde for the evaluation of joint model with time to event data

18:30-01:00	Social event


Friday

09:20-09:40	Oncology		Chair: Ana Ruiz, Siv Jönsson

09:20-09:40	Aurelia de Vries Schultink	Prospective evaluation of Therapeutic Drug Monitoring of endoxifen: feasibility of observational and randomized trials.

09:40-10:00	Coralie Tardivon	Association between tumor size kinetics and survival in advanced urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up

10:00-10:20	Jiajie Yu	A new approach to predict PFS in Ovarian Cancer based on tumor growth dynamics.

10:20-10:25	Preview of PAGE 2020


10:25-11:00	Coffee break


11:00-11:40	Oncology, continued		Chair: Marylore Chenel

11:00-11:20	Julie Janssen	A semi-physiological framework to predict changes in pharmacokinetics of cytotoxic drugs in pregnant women

11:20-11:40	James Lu	Integrated efficacy-safety QSP model of acute myeloid leukemia (AML) generates insights into the role of clinical dose schedules on cytopenia

11:40-11:50	Closing remarks


11:50-12:05	Audience input for potential PAGE 2020 topics