Abstracts - PAGE Meeting (Population Approach Group Europe)

Abstracts (27)

B-03Jeff Sachs

Pharmacometrics: A shot in the arm for vaccine discovery and development ~or~ Vaccines are not immune to the charms of pharmacometrics

Wednesday 09:00-09:45

B-06Marjorie Imperial

Stratified medicine approaches for drug susceptible tuberculosis patients

Wednesday 11:15-11:35

B-07Stefanie Hennig

Repeated time-to-event models support that Pseudomonas aeruginosa infection increase the risk of acquiring Aspergillus in young children with cystic fibrosis

Wednesday 11:35-11:55

B-08María García-Cremades

Individual level data meta-analysis from HIV pre-exposure prophylaxis (PrEP) clinical trials

Wednesday 11:55-12:15

B-10Nicky Best

Use of informative priors in model-informed drug development

Wednesday 13:45-14:30

B-11Chiara Nicolò

Machine learning combined to mechanistic modeling of differential effects of neoadjuvant sunitinib on primary tumor and metastatic growth

Wednesday 14:30-14:50

B-12Sebastien Benzekry

Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer

Wednesday 14:50-15:10

B-15João Abrantes

Bayesian forecasting utilizing bleeding information to support dose individualization of factor VIII

Wednesday 16:45-17:05

B-16Belén Pérez Solans

Model-based characterization of neutrophil dynamics in children receiving busulfan or treosulfan for hematopoietic stem cell transplant conditioning

Wednesday 17:05-17:25

B-17Zinnia Parra-Guillen

Disease pharmacokinetic-pharmacodynamic (PKPD) modelling to support the development of gene therapy treatments for rare diseases

Wednesday 17:25-17:45

B-18Pascal Chanu

A disease progression model for geographic atrophy

Wednesday 17:45-18:05

C-01Moustafa M. A. Ibrahim

Competing risks analysis of the Finnish diabetes prevention study

Thursday 08:30-08:55

C-02Sebastiaan Goulooze

Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children

Thursday 08:55-09:20

C-03Elena Tosca

Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset

Thursday 09:20-09:45

C-07Kristin Karlsson

Regulatory model-informed drug discovery and development in EU – News flash and examples

Thursday 11:20-12:05

C-08Sylvie Retout

A model-based extrapolation enabled labelling of emicizumab in haemophilia A paediatric patients <1 year old despite lack of clinical data

Thursday 12:05-12:25

C-12Theodoros Papathanasiou

Model based optimization of dose-finding studies for drug-combinations.

Thursday 14:00-14:20

C-13Antonio Goncalves

Model Averaging in viral dynamic models

Thursday 14:20-14:40

C-14Mohammed Cherkaoui Rbati

A liver model for chemoprotection against malaria

Thursday 14:40-15:00

C-15Xiao Zhu

A cohesive model framework of receptor pharmacology: beyond the Emax model

Thursday 15:00-15:20

C-18Alison Margolskee

Exploratory graphics (xGx): promoting the purposeful exploration of PKPD data

Thursday 16:50-17:10

C-19Marc Cerou

Performance of npde for the evaluation of joint model with time to event data

Thursday 17:10-17:30

D-01Aurelia de Vries Schultink

Prospective evaluation of Therapeutic Drug Monitoring of endoxifen: feasibility of observational and randomized trials.

Friday 09:20-09:40

D-02Coralie Tardivon

Association between tumor size kinetics and survival in advanced urothelial carcinoma patients treated with atezolizumab: implication for patient’s follow-up

Friday 09:40-10:00

D-03Jiajie Yu

A new approach to predict PFS in Ovarian Cancer based on tumor growth dynamics.

Friday 10:00-10:20

D-06Julie Janssen

A semi-physiological framework to predict changes in pharmacokinetics of cytotoxic drugs in pregnant women

Friday 11:00-11:20

D-07James Lu

Integrated efficacy-safety QSP model of acute myeloid leukemia (AML) generates insights into the role of clinical dose schedules on cytopenia

Friday 11:20-11:40