20th PAGE Meeting

Athens - Greece
7-10 June, 2011

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Abstracts (16)

I-22Irina Bondareva

Sequential Interacting Multiple Model (IMM) Bayesian Analysis of Carbamazepine and Valproate Repeated Therapeutic Drug Monitoring (TDM) Data from Epileptic Patients

Wednesday 10:15-11:45

I-32Jacob Brogren

Separate vs. simultaneous analysis of co-primary endpoints in Alzheimer’s disease clinical trials

Wednesday 10:15-11:45

I-56Elizabeth de Lange

Mechanism-based PK-PD model of remoxipride with rat-to-human extrapolation: characterizing remoxipride target site PK and systems homeostatic feedback

Wednesday 10:15-11:45

II-25

Predicting Dopamine D2 Receptor Occupancy in humans using a physiology-based approach

Wednesday 14:55-16:10

II-26

Pharmacokinetic-Pharmacodynamic Modeling of Dopamine D2 Receptor Occupancy in humans using Bayesian modeling tools

Wednesday 14:55-16:10

II-34Zheng Guan

Population pharmacokinetic and pharmacodynamic analysis of cortisol in serum and saliva in healthy male volunteers after an acute 5-hydroxytryptophan (5-HTP) challenge test

Wednesday 14:55-16:10

II-42Eef Hoeben

Population pharmacokinetic analysis of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia

Wednesday 14:55-16:10

II-48Masoud Jamei

A physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain

Wednesday 14:55-16:10

II-65Huub Jan Kleijn

Development and Application of a Semi-Mechanistic Model for Modulation of Amyloid-beta in Cerebrospinal Fluid after Inhibition of γ-secretase.

Wednesday 14:55-16:10

III-16Arianna Madrid Aispuro

Modelling the sleep effects of Zolpidem in rats using non-homogeneous Markov chain models

Thursday 09:50-11:05

III-25François Mercier

A Bayesian meta-analysis of longitudinal lesion count data in multiple sclerosis patients

Thursday 09:50-11:05

III-56Venkatesh Pilla Reddy

Exposure-Response Relationship of Typical and Atypical Antipsychotics Assessed by the Positive and Negative Syndrome Scale (PANSS) and its Subscales

Thursday 09:50-11:05

III-58Bart Ploeger

Confirmation of symptomatic and disease modifying effects of levodopa using the ELLDOPA study

Thursday 09:50-11:05

IV-15Ahmed Suleiman

A Mixed-Effects Markov Model for Characterizing the Time Course of the Transitions between Different Extrapyramidal Side Effects Severity Levels

Thursday 15:05-16:20

IV-19Stina Syvänen

Quinidine Microdialysis Reveals Altered P-glycoprotein Function in Epileptic Rats in the Brain Parenchyma Rather than at the Blood-Brain Barrier

Thursday 15:05-16:20

IV-30

A pharmacokinetic/pharmacodynamic analysis of central and peripheral effects of GSK3 inhibitors

Thursday 15:05-16:20