Program - PAGE Meeting (Population Approach Group Europe)

Tuesday June 8
16:00-20:00	Registration

18:00-20:00	Welcome reception

Wednesday June 9
08:00-08:45	Registration

08:45-09:00	Welcome and Introduction

09:00-10:20	Physiology based modelling		chair: Charlotte Kloft
09:00-09:40	Wilhelm Huisinga	Physiologically-based pharmacokinetic/pharmacodynamic modelling, mathematical model reduction and a mechanistic interpretation of simple empirical models
09:40-10:00	Martin Bergstrand	Semi-mechanistic modeling of absorption from extended release formulations - linking in vitro to in vivo
10:00-10:20	Stefan Willmann	Investigation of the Influence of CYP3A4 Inhibition and Renal Impairment on Morphine and M6G Formation after Codeine Administration using Coupled Whole-Body PBPK Modelling

10:20-11:50	Coffee break, Poster and Software session I
	Posters in Group I (see below) are accompanied by their presenter

11:50-12:30	Physiology based modelling (continued)		chair: Katya Gibiansky
11:50-12:10	Pascal Chanu	Mechanistic Models to Simulate Dose Response of IgE Suppression Following Dosing of Anti-IgE Monoclonal Antibodies
12:10-12:30	Julia Korell	Design of survival studies for red blood cells

12:30-14:00	Lunch

14:00-15:15	Covariate model building		chair: Mats Karlsson

14:00-14:55	*Stephen Senn*	Tutorial: Covariate complications in clinical trials
14:55-15:15	Akash Khandelwal	Covariate Model Building Using Linear Approximations

15:15-16:30	Tea break, Poster and Software session II
	Posters in Group II (see below) are accompanied by their presenter

16:30-17:30	Methodology		chair: France Mentré
16:30-16:50	Brigitte Lacroix	Evaluating the IPPSE method for PKPD analysis
16:50-17:10	Dalia Khachman	You have problems to interpret VPC? Try VIPER!
17:10-17:30	Bruno Boulanger	Trial predictions vs. trial simulations in early clinical development: a framework to evaluate the predictive probability of success based on NONMEM outputs


Thursday June 10
08:45-10:05	Lewis Sheiner Student Session		chairs: Chantal Csajka, Ferdie Rombout, Willi Weber
08:45-09:10	Caroline Bazzoli	Design evaluation and optimisation in multi-response nonlinear mixed effect models with cost functions: application to the pharmacokinetics of zidovudine and its active metabolite
09:10-09:35	Maud Delattre	Estimation of mixed hidden Markov models with SAEM. Application to daily seizures data
09:35-10:00	Lay Ahyoung Lim	Dose-response-dropout analysis for somnolence in Pregabalin-treated patients with generalized anxiety disorder
10:00-10:05	Presentation of Awards

10:05-11:20	Coffee break, Poster and Software session III
	Posters in Group III (see below) are accompanied by their presenter

11:20-12:20	Clinical applications of PK(PD)		chair: Dinesh de Alwis
11:20-11:40	Chao Zhang	Population Pharmacokinetics of Lopinavir/Ritonavir in Combination with Rifampicin-based Antitubercular Treatment in HIV-infected Children
11:40-12:00	Jeff Barrett	Enhancing Methotrexate Pharmacotherapy in Children with Cancer: A Decision Support System Integrating Real-time PK/PD Modeling and Simulation with Patient Medical Records
12:00-12:20	Sarah McLeay	Exploring different body-size metric based dosing strategies for propofol in morbidly obese versus healthy weight subjects by modelling and simulation approach

12:20-13:50	Lunch

13:50-15:15	Integrating data with literature		chair: Lutz Harnisch
13:50-13:55	Lutz Harnisch	Introduction to integrating data with literature
13:55-14:15	Eugene Cox	Meta- Analysis of Retention Rates of Post-Marketing Trials to Compare Effectiveness of Second Generation Antiepileptic Drugs
14:15-14:35	Rocío Lledó-García	A mechanistic model of the steady-state relationship between HbA1c and average glucose levels in a mixed population of healthy volunteers and diabetic subjects
14:35-15:15	Jonathan French	When and how should I combine patient-level data and literature data in a meta-analysis?

15:15-16:30	Tea break, Poster and Software session IV
	Posters in Group IV (see below) are accompanied by their presenter

16:30-17:10	Design		chair: Marylore Chenel
16:30-16:50	Camille Vong	Rapid sample size calculations for a defined likelihood ratio test-based power in mixed effects models
16:50-17:10	Lee Kien Foo	D-optimal Adaptive Bridging Studies in Pharmacokinetics

19:00-01:00	Social evening


Friday June 11
09:00-10:00	Stuart Beal Methodology Session		chair: Oscar della Pasqua
09:00-09:20	Marc Lavielle	Mixture models and model mixtures with MONOLIX
09:20-09:40	Matthew Hutmacher	Extending the Latent Variable Model to Non-Independent Longitudinal Dichotomous Response Data
09:40-10:00	Elodie Plan	Analysis Approaches Handling Both Symptomatic Severity and Frequency

10:00-10:10	Preview of PAGE 2011

10:10-10:50	Coffee Break

10:50-12:10	PKPD models		chair: Nick Holford
10:50-11:10	Sylvain Goutelle	Mathematical modeling of pulmonary tuberculosis therapy: development of a first prototype model with rifampin
11:10-11:30	Alberto Russu	Integrated model for clinical response and dropout in depression trials: a state-space approach
11:30-11:50	Klas Petersson	Predictions of in vivo prolactin levels from in vitro Ki values of D2 receptor antagonists using an agonist-antagonist interaction model
11:50-12:10	Rada Savic	Adherence and Population Pharmacokinetics of Atazanavir in Naïve HIV-Infected Patients using Medication Events Monitoring System (MEMS) for drug intake timing

12:10-12:20	Closing Remarks

12:20-12:50	Audience Input for the PAGE 2011 Program