My Profile

Search abstracts

Lewis Sheiner

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

Printable version

   Glasgow, Scotland

Twenty-second meeting, 11-14 June, 2013

The PAGE 2013 meeting was hosted by the University of Strathclyde and the City of Glasgow and was held in the Glasgow Royal Concert Hall


Coned Duke of Wellington

The Duke of Wellington Statue in Glasgow, with his traffic cone hat



Our sponsors:





PAGE meetings take place in an informal atmosphere with vivid scientific discussion. The meeting will start with a Welcome Reception at 6:30 pm on Tuesday 11 June at the Old Fruitmarket. The scientific programme will start on Wednesday morning (12 June) and will end at noon on Friday 14 June. Participants are encouraged to attend all conference days and present their work in the form of an oral presentation or poster.

Abstracts and Apps

The program and abstracts can be downloaded as a single document (pdf, rtf or doc, and a special small-page  A5-sized pdf version for unsupported phones and e-books): note that no printed abstracts are available at the conference so print them at home or use the special Apps that have been developed for iPhone and Android to view all abstracts off-line on your portable device.

Conference location

PAGE 2013 will be held at the Glasgow Royal Concert Hall, 2 Sauchiehall Street, Glasgow G2 3NY. For a map of Glasgow City Centre, see this link. Glasgow Royal Concert Hall is situated at the top of Buchanan Street and at the end of Sauchiehall Street. 


The registration desk can be accessed from the entrance at the top of Buchanan Street. Disabled access is via the North Door on Killermont Street.Registration will be open at the following times:
Tuesday 11th June: 15:00 hours – 18:30 hours
Wednesday 12th June: 08:00 hours – 18:00 hours
Thursday 13th June: 08:00 hours – 17:30 hours
Friday 14th June: 08:30 hours – 13:00 hours

Welcome Reception, Tuesday 11th June

The meeting will open with a civic-sponsored drinks reception from 18:30 to 19:30 hours in the Old Fruitmarket, located on Candleriggs in the Merchant City area, close to the city centre.  Please see the map on

Programme items:

  • The Lewis Sheiner Student Session
    The annual Lewis Sheiner Student Session was inaugurated, both to honour the memory of Lewis Sheiner and to highlight his lifetime passion for student education. Students who wish to be considered for this session should submit an extended abstract by the end of 1 March 2013.
    • The abstract must be structured with the following subheadings: Objectives / Methods / Results / Conclusion / References.  
    • There must be at least 6,000 but not more than 7,000 characters (including spaces) in the abstract itself, i.e. excluding Title / Authors/ Affiliation and References.
    • The submitted work must have been performed either as part of an MSc or PhD programme and/or will ultimately form part of a PhD thesis. 
    • Each year a rotating committee of three members, representative of the PAGE community, will judge who should receive the honour of presenting in the Lewis Sheiner Student Session. 
    • If elected, the student will automatically receive a 300 euro travel grant.  A permanent list of students, with links to their presentation, will be maintained on the web site.
  • The Stuart Beal Methodology Session
    As a tribute to Stuart Beal, the organising committee has instituted the Stuart Beal Methodology Session. The organising committee will choose presenters from the submitted abstracts.
  • Tutorial on reproducible research
    • Tutors: Justin Wilkins and Niclas Jonsson 
  • Special session on modelling animal health
    • Invited Speakers: Prof. Jim Riviere (Kansas State University), Prof. Dan Haydon (University of Glasgow) and Prof. George Gettinby (University of Strathclyde)
  • Invited lecture on pharmaco-economics by Dyfrig Hughes (Bangor University): Quantitative benefit-risk analysis based on linked PKPD and health outcome modelling



  • Registration was opened on Monday 14 January 2013 at 9 AM UK time (GMT+0)and is only possible at the PAGE website.
  • If you have previously registered at the PAGE website, your personal details (address etc.) are still available.
  • If you have not previously registered at the PAGE website, please do so first, then you can log in to enrol for the meeting.

Please keep our database up to date by editing your existing profile if required!

  • If you've forgotten your password, a reminder can be requested automatically from the website by e-mail.
  • If you've forgotten your password and changed your e-mail address then please contact Rik Schoemaker (
  • Updates of personal details in the website are confirmed automatically by email. Note that if you do not receive a confirmation, you should check that your e-mail address is correctly entered in the designated field.

Registration fees and payment

  • Registration fees are:
    • £500 for participants from industry and commercial enterprises
    • £350 for academics and non-profit participants (including government employees)
    • £100 for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do notsubmit and present a poster or oral communication abstract at PAGE 2013
    • £25 for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do submit and present a poster or oral communication abstract at PAGE 2013
  • Fees include coffee, tea and lunch on all days, the Welcome Reception on June 11 and the Social Event on June 13. 
  • Accompanying persons can attend the welcome reception and the social event for a fee of £120.
  • Participant places are limited and allocated on a first come, first serve basis.
  • Full payment details and conditions can be obtained here (pdf for download)
  • Registration fees must be paid through the Meeting Makers, local organiser website ( 
  • Meeting Makers will send you an email with a login code to gain access to the registration site. Please allow at least one business day for your PAGE website registration information to be transferred to the Meeting Makers database. 
  • Registration fees must be paid by bank transfer or credit card (VISA, Maestro and MasterCard only) within 14 days after registering at the PAGE website. Failure to meet this deadline will automatically place your registration on the waiting list.
  • Students wishing to qualify for the £25 registration fee need to send a scanned copy of a signed letter of support from their supervisor and a scan of their current student card to If this information and an abstract are not available at the time of the abstract deadline (15 March),  the standard student fee will be charged.
  • Students wishing to qualify for the £100 registration fee need to send a scanned copy of a signed letter of support from their supervisor indicating that they are full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed), and a scan of their current student card to   
  • Please contact Meeting Makers directly at or call tel +44 (0) 141 945 6880 or Fax +44 (0) 141 945 6899 if you have any special requests or special needs.

Cancellation policy

No refunds will be given if the registration fee has been paid, not even in the extremely unlikely event that the meeting is cancelled due to force majeure. Substitution of delegates will be accepted at any time.

Pharsight Student Sponsorship

Student registration fees have been significantly decreased this year. As a consequence, the Pharsight Student Sponsorship to support travel and accommodation expenses, is now only available to a very restricted number of students unable to obtain any other financial support. This will be judged on a case-by-case basis by a selection committee. Please see here to download a form with criteria and details on how to apply.

Accomodation reservation: all accomodation facilities available through MeetingMakers have been booked

  • Meeting Makers, the local organiser agency, has reserved accommodation at special rates for the PAGE meeting. An overview of the hotel and University accommodation options can be obtained here (pdf for download) and a map of hotel locations can be found here (google maps page). Do note that all accomodation facilities available through MeetingMakers have been booked.  
  • University and hotel accommodation must be paid in full at the time of booking (or following receipt of invoice).  Payments must be received before 5 April 2013 or accommodation cannot be guaranteed. Accommodation will be held on a provisional basis until payment is received.
  • For cancellations received on or before 5 April 2013 – no penalty. No refunds will be given after 5th April and full payment will be due.  All cancellations must be received in writing – by email, fax or hard copy mail. Any reduction in nights will be treated as a cancellation and no refund will be given. Any refunds given will be subject to a charge of £20.

Abstract submission

Deadline for Lewis Sheiner Student Session abstracts: 1 MARCH 2013
Deadline for regular abstracts: 15 MARCH 2013

  • Please follow these instructions carefully regarding format and length of the abstracts or download them in either Word/RTF or Adobe/PDFformat. Abstracts that do not comply with these guidelines will not be accepted.
  • To limit the large number of posters at PAGE meetings, please note that each participant is only allowed to submit one poster abstract. 
  • Do not submit separate oral and poster abstracts: if your request for an oral presentation is not granted, you will be contacted to switch your abstract from an oral to a poster category.
  • Submission of abstracts is only possible online through the PAGE website. Log in, click on 'Register/submit abstract' and click the link on the bottom of your personal info page.
  • To facilitate the review of abstracts and to help structure the poster sessions, please select an abstract category when you submit your abstract. 
  • The abstract must be structured with the following headings: Objectives / Methods / Results / Conclusion / References.  
  • There is a strict limit of 1,000 to 2,500 characters (including spaces) for the abstract itself (i.e. excluding Title/ Authors/ Affiliation and References).    
  • When you click "Submit" you will immediately receive an email with your abstract attached. This e-mail will also be sent to the committee responsible for peer review in the selected category. Therefore, only click "Submit" when you are done editing!
  • Abstracts will remain invisible until release of the final programme (anticipated date: between 5 and 15 April).


The poster boards will accommodate an A0-size portrait poster (118.9 cm high and 84.1 cm wide/46.8 by 33.1 inches). Material for mounting your poster to the boards will be available on-site.

Software demonstrations

Software companies, Academic Software Application Developers and Contract Research Organisations are welcome to present their products and services during PAGE. Please contact the conference secretariat for further details at

Satellite meetings

Several events will be held before and after the PAGE meeting (more information to follow). If you are interested in organising such a satellite meeting, please download this document with additional information. Please note that PAGE itself does not get involved in organising satellite workshops or booking venues, etc, and satellite meetings cannot be booked through the PAGE or local organisers web-site.

  • Simcyp Limited (now part of Certara) is running a one-day hands-on workshop on Tuesday 11th June to give an opportunity for becoming familiar with this increasingly popular platform. The software is used by many groups for the purpose of simulations and in vitro in vivo extrapolation as part of regulatory package. However, pharmacometric features such as user defined PD models and its powerful fitting tools for complex PBPK models are less commonly known outside DMPK circles.  These capabilities are for both small and larger molecules. The course will be a bridge between mechanistic covariate recognition, complex model fitting and rational design of studies. Cost: Academics & Simcyp Consortium Member Companies: £75 Non Members: £200. For further details click here.
  • A 2 days MONOLIX 4.2 workshop presented by Marc Lavielle will be given on the 10th and 11th of June. The course is designed for both beginners and advanced PK-PD modellers and will provide a complete presentation of the latest version Monolix 4.2. The algorithms used in Monolix and several advanced features for modeling will be presented (Bayesian estimation, mixture models, flexible censoring processes, extensive diagnostic plots, etc). The course will also include training on MLXtran, an easy and powerful declarative script language for programming simple and complex pharmacometric models, including models for continuous data, categorical data, count data, time-to-event data and more. MLXtran can now be used with R and Matlab, or with MLXplore, a new graphical and interactive tool for exploring complex pharmacometric and statistical models. For further details click here.
  • The Uppsala Pharmacometrics Group and is happy to announce a 2-Day Course on Covariate Model Building and Evaluation tailored for Intermediate and Advanced NONMEM users on June 10-11. The course will present modeling strategies, techniques and implementations for the handling of covariate information in population models. Traditional methods will be complemented with recent advances in covariate model building methodology and diagnostics for more efficient, robust and informed covariate models. The course will consist of both lectures and hands-on computer exercises using NONMEM 7, PsN and Xpose 4. Self-instructive material is provided for further studies and exploration of additional examples within the field. The participants will be provided with a NONMEM library of examples. More details on this covariate course are available here.
  • A one day workshop on Modeling Biologics with Target-Mediated Disposition will be presented by Leonid Gibiansky and Ekaterina Gibiansky from QuantPharm LLC, and organized by AP2POP on Tuesday 11 June 2013. The workshop is intended for PK scientists with or without prior population PK modeling experience. It will provide an overview of the PK of biologics, introduce target-mediated drug disposition (TMDD) modeling concepts, and discuss some applications of TMDD modeling to drug development of biologics. NONMEM codes, inputs and outputs for TMDD modeling will be provided to the participants. The course will be organized at the University of Strathclyde, close to the PAGE Meeting venue. For further details click here.
  • The Animal Health Modeling & Simulation Society (AHM&S) will run its first live meeting at the University of Strathclyde, Glasgow, Monday June 10th, 2-6 pm. The AHM&S is a newly founded association (2012) that aims at promoting the development, application, and dissemination of Modeling and Simulation techniques in the field of Veterinary Pharmacology and Toxicology. The primary objective of the society is to maximize the value of available pharmacokinetic/pharmacodynamic datasets (both sparse and rich) to identify physiological and pathological factors that account for differences in drug safety and efficacy in animals, as a result of between and within-subject variability. The association is co-chaired by Pr. Johan Gabrielsson (Europe) and Pr. Jim Riviere (USA), and currently counts about 15 core members from both academia and industry. For more information, download the program here.
  • ICON will present a one-day NONMEM 7 course on 11 June. This workshop will cover the description and use of features in NONMEM 7. Workshop attendees will be instructed how to specify gradient precision for the improved FOCE algorithm, and will also be instructed on how to use the Monte Carlo importance sampling, stochastic approximation expectation-maximization methods, and full Bayesian methods. Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as new features of NONMEM 7.3, such as symbolic references to thetas, etas, and sigmas, priors to sigmas, MonteCarlo search algorithms to improve FOCE estimation, built-in individual weighted residuals,
    bootstrap tools for simulation, and greater control in average eta shrinkage calculations.  The features of PDx-POP 5.1, the graphical interface for NONMEM 7, will also be demonstrated.  For details and registration check here or contact IDSSoftware@iconplc.comfor more information.
  • GRIP – Global Research in Paediatrics is pleased to announce the one-day Workshop on Extrapolation and Evidence Synthesis in the Development and Therapeutic Use of Medicines in Children, which will be held the University of Strathclyde, Glasgow on Tuesday, 11th June, from 09:00 -17:15 h. GRIP is a network of excellence funded under the auspices of FP7 and aims to improve child health by stimulating and facilitating the development and safe use of paediatric medicines. The primary objective of this workshop is to review the current methodologies for evidence generation and evidence synthesis in paediatric research, including opportunities for extrapolation and optimisation of experimental protocols. Attention will also be given to issues such as the choice of comparators when defining efficacy and safety in children. A preliminary programme can be found here. These topics have become increasingly important with the recent changes in the legislation, which acknowledges the need for appropriate evaluation of medicines in children prior to regulatory approval and therapeutic use.  
    PAGE participants are welcome to join the meeting and contribute to the discussion. A reflection document will be prepared based on the points raised during the workshop and submitted as recommendations for industry, regulators, paediatricians, and patient organisations. The workshop is free of charge, but registration is required due to venue capacity (max 85). Please contact Sven van Dijkman ( providing your name, email, organisation, arrival date in Glasgow and a short description of your motivation  ( e.g., specific interest or experience in paediatric drug development).  Registration will be on a first-come first-served basis.
  • Pharsight will run a 1.5 day course on Categorical Responses in Population Analysis using Phoenix NLME, from Monday 0830 to Tuesday Lunchtime and you can find more details and enroll using this link. The objective of this course is to train NLME users how to perform Advanced population PK/PD using Phoenix NLME with a focus on the QRPEM algorithm and its implementation for categorical responses. A limited number of academic/student places are available on application, just register and add your request in the “dietary” section. Following this, on the Tuesday afternoon there will be a free demonstration workshop for which you must register using this link on Phoenix Connect: Linking Modeling and Simulation Tools, including NONMEM, R, Xpose & PsN, in Phoenix Workflows and subsequently producing Word Reports directly. This is mostly a repeat of last year’s session following several requests for it to be repeated, addtionally the new Reporter tool will be covered.
    Phoenix Connect can help you bridge the gaps that lie between the silos and systems that you depend on by creating connections between many common drug development software systems and protocols, such as, PsN, Xpose, SAS, S-plus, R and NONMEM.
  • Physiomics will present a half-day workshop on The Prediction of Cardiotoxicity Using In Silico Tools (Tuesday the 11th of June, 1:30 pm – 4:30 pm; no registration fees). The workshop will review models currently available for analysing cardiac toxicity, from effects on individual myocyte action potentials to Torsade de Pointes risk categorisation. This will be followed by the presentation of Physiomics’ own cardiotoxicity prediction approach. The workshop will also include an interactive session, where participants will have the opportunity to predict the cardiotoxic risk for a set of drugs, based on in vitro assay data (provided in advance), and to compare their predictions with those made by published models and Physiomics’ technology. For more details click here.


Glasgow is Scotland's largest city (population around 600,000) and dates from 543 AD when St Mungo established a church in Glas Cu, (“dear green place”).  This became the site of Glasgow Cathedral in 1238 and Provand’s Lordship, Glasgow’s oldest house, was built opposite the Cathedral in 1471. Glasgow’s location on the west coast of Scotland facilitated trade with the “New World” and from the 1500s to the 1700s, Glasgow prospered by importing tobacco and sugar. Glasgow’s “golden age” of engineering, shipbuilding and heavy industry lasted from the mid-1800s until the early 1900s, when it was one of the richest cities in Europe. Many of the grand public buildings, houses, museums, galleries and libraries that can be seen in the city today were built around that time.  Architectural highlights include the works of Charles Rennie Mackintosh (1868-1928, Glasgow Art School, Willow Tea Rooms, House for an Art Lover, etc.) and Alexander “Greek” Thomson (1817-1875, Buck's Head Building, St Vincent Street Church, Great Western Terrace, etc.)
Further information on Glasgow and Scotland is available at the following websites
Dedicated iPhone and Android Apps for Glasgow can be obtained at:

Glasgow location & weather

Glasgow is situated in west central Scotland with easy access to the Loch Lomond and the Highlands in the north and the islands of Arran and Cumbrae in the south west.  It is only 42 miles from Scotland's capital city of Edinburgh in the east and there are regular train and bus connections between the two cities.  The west of Scotland is famously able to offer four seasons in one day… and sometimes in one hour! In June, it can be dry and sunny or wet and windy or just cloudy.  The most likely weather is a mixture! Typical temperatures range from 12 – 25°C with an average around 17°C.

Getting to Glasgow

Glasgow is served by three international airports: Glasgow Airport, 20-25 minutes by bus to the city centre or 15-20 minutes by taxi; Prestwick Airport (30 minutes by train, 50 minutes by bus) and Edinburgh Airport (around 1.5 hours by bus to train station then train).  There are two mainline rail stations in the centre of the city, Central Station, which connects with major cities in England, and Queen Street, which connects with Edinburgh and the north of Scotland.  More details about travel to Glasgow can be found here.

Conference secretariat

For matters related to the PAGE meeting:

For matters related to payment of registration fees, hotel reservation, tourist information etc:
PAGE 2013 Secretariat
Meeting Makers
Block 4, Unit 4, Kelvin Campus, West of Scotland Science Park,
2317 Maryhill Road, Glasgow G20 0SP
Telephone number: +44 (0) 141 945 6880
Fax: +44 (0) 141 945 6899