D. Breilh, C. Pobel, M.C. Saux
Laboratory of Clinical Pharmacokinetic, Bordeaux II University, France
20 volunteers, male, with the following average characteristics
were investigated; age 24.1
3.57 years, weight 70.7
8.5
kg, height 178.7
7.50 cm, body surface area 1.88
0.139
. The patients were given 0.6 g/kg of alcohol per os from a
100ml glass of pure vodka, the average dose of alcohol is
42.42
5.10g.
The kinetics of alcohol is done via blood samples N = 16/patients over a period of time comprised between 0 and 6 hours after administration of the 100ml of vodka.
The use of covariables of interest has been studied; genotype of ADH3 , age, weight and body surface area.
The NONMEM subroutine is ADVAN6, TRANS1 and the error model is multiplying.
Results:
Incorporating covariables in the model does not modify the mean values of parameters but shows a significant increase in CV%. During the study on multiple regression, covariables did not explain variability in KM and Vm, particularly the genotype.
The mean values of the population parameters are close to the reference values described in literature (Wilkinson and all) as for individual pharmacokinetics. NONMEM seems to be a reliable means of modeling population as for pharmacokinetic observations describing a non linear process.