2021 - Ljubljana - Slovenia

2021 - Ljubljana - Slovenia

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SATELLITE MEETINGS

Several events will be held before and after the PAGE meeting. If you are interested in organising such a satellite meeting, please contact the local organising agency AFEA SA at pagemeeting2020@afea.gr. Please note that PAGE itself is not involved in organising satellite workshops or booking venues, etc, and satellite meetings cannot be booked through the PAGE web-site.

  • The ISoP Student Community and the ISoP Clinical Pharmacometrics SIG are organising a 1-day Educational Pharmacometrics Summer Symposium titled Pharmacometrics: from here to where? on Tuesday 9th June 2020. The aim of this Symposium is to present an overview of how Pharmacometrics (PMx) can contribute to the drug development and therapy individualisation. Topics covered:

    • Introduction to PMx (basic principles)
    • The role of PMx in industry to guide drug development
    • The role of PMx in the clinic (therapy personalisation & optimisation)
    • Application of PMx (case-studies)

    The symposium is meant for students, clinicians, pharmacists and other researchers with an interest in PMx. PhD students or Postdocs/trainees attending PAGE may apply to present their original work as part of the symposium. The participation is free of charge and limited to 100 participants. Light lunch and coffee will be provided. To register please follow this link. For more information please email: EPmxSS2020@gmail.com.

  • Certara UK Limited, Simcyp Division is running a one-day Parameter Estimation and Pharmacodynamics (PE/PD) hands-on workshop on Tuesday 9th June 2020. During the workshop through a combination of lectures and hands-on exercises you will get familiar with the concepts and application of combining the top-down and bottom-up approaches to build fit for purpose PBPK models and the further link PBPK models to PD models to provide insight into covariate impacts on drug response.

    The major topics covered are:

    • Data entry, fitting and interpretation of results
    • Global Sensitivity Analysis of PBPK/PD models
    • Simultaneous fitting of PK and PD parameters (at both Population and Individual levels)
    • Covariate recognition
    • Using built-in and custom scripted pharmacodynamic models in Simcyp
    • PD driven by the concentration at the relevant site of action e.g. liver
    • The Simcyp R package to run the Simcyp Simulators from R

    This course is run using the Amazon Workspaces Cloud Application; please ensure you bring a laptop computer. Cost: Academics and Simcyp Consortium members £300.00, Non Members £400.00. To register please click here or email Kelly at events@simcyp.com.

  • Certara UK Limited, Simcyp Division is running a one-day Bridging PBPK with POPPK for Paediatrics/Pregnancy workshop on Tuesday 9th June 2020 on predicting the age-related changes to pharmacokinetics and drug-drug interactions including associated variability and linking this information to drug response in the preterm and full term Caucasian and Japanese paediatric populations and pregnant women. Examples of how these can inform the design of POPPK studies will be presented during the course.

    The major topics covered are:

    • Applications of IVIVE techniques in predicting PK
    • Age/gestational-dependent physiological changes and their impact on PK for small and large molecules
    • Handling Age- and Time-varying covariates during simulation
    • Prediction of DDI in paediatrics
    • Linking PK variability to drug response in children
    • Strategies for optimal study design using combination of PBPK and POPPK

    This course is run using the Amazon Workspaces Cloud Application; please ensure you bring a laptop computer. Cost: Academics and Simcyp Consortium members £300.00, Non Members £400.00. To register please click here or email Kelly at events@simcyp.com.

  • IntiQuan will present a full-day workshop entitled Advanced QSP Modeling – From Clinical Data to Virtual Subjects, Cohorts, and Populations on Tuesday, June 9, 2020. Special emphasis is put on the estimation of individual parameters based on clinical data, allowing to determine Virtual Subjects, Cohorts, and Populations in an estimation-based approach that is suitable even for large scale models and a large number of subjects in the considered data. The ability to estimate such individual level parameters in QSP models has the potential to open up advances in diagnostics through the use of advanced statistical methods. The cost will be 600 EUR for industry, 300 EUR for academia / government/ non-profit and 100 EUR for students. Click here for details and registration.

  • IntiQuan will present a full-day workshop entitled  Population PK/PD modeling in R on Tuesday, June 9, 2020. The workshop is designed as a hands-on tutorial and focus on PKPD/NLME modeling workflow from data exploration, parameter estimation, and reporting in the R environment using our IQR Tools R package. After the workshop, the participants will be able to set up their own PKPD/NLME workflow using IQR Tools to explore the modeling dataset, perform parameter estimation in supported NLME tools, and evaluate parameter estimation results. Furthermore, participants will be able to generate reports in Microsoft Word directly from the results generated in R. The cost will be 600 EUR for industry, 300 EUR for academia / government/ non-profit and 100 EUR for students. Click here for details and registration.

  • The xGx/nlmixr/ggPMX team will be offering a one-day workshop entitled An open-source Pharmacometrician’s workflow in R: from data exploration (xGx) to model building (nlmixr) and diagnostics (ggPMX) on Tuesday, June 9, 2020. The workshop consists in presenting three free open-source R packages developed by Novartis:

    The participants will have a chance to experience the stepwise framework of the Pharmacometric’s workflow. First, through a question-based approach, xGx helps to uncover useful insights in the data that can be revealed without complex modeling and to identify data aspects that may be explored further. Next, nlmixr is used for building an adequate population model to characterize the dose-exposure-response relationship. Finally, the model evaluation, validation and reporting is supported by ggPMX. Diagnostic plots help assessing the goodness-of-fit of a given model and selecting the model describing the data most accurately. The course will consist of a mixture of lectures and hands-on exercises. For further details and questions on the workshop, please contact Bruno Bieth at bruno.bieth@novartis.com. For registration, please visit this pageCost: 150 euros for industry, 100 euros for academia/government/non-profit and 50 euros for students to cover the workshop room, lunch and coffee/tea.

  • ICON will present a one-day NONMEM 7 course on Monday 8 June. Workshop attendees will be instructed on how to implement the FAST FOCEI algorithm (new in NONMEM 7.4), how to use Monte Carlo importance sampling, stochastic approximation E-M methods, and full Bayesian methods, both traditional Gibbs Bayesian and Hamiltonian no U-turn sampling (new in NONMEM 7.4). Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as additional new features of NONMEM 7.4. The features of PDx-POP 5.2, the graphical interface for NONMEM 7, will also be demonstrated. Cost will be $500 for industry, $250 for academia, and $100 for students. For details and registration contact Lisa Wilhelm-Lear @ Lisa.Wilhelm@iconplc.com.  

  • Lixoft is running a 1 day hands-on workshop on tumor growth and tumor growth inhibition modeling with the MonolixSuite on Tuesday the 9th of June. A variety of ODE-based models have been published to describe data of longitudinal tumor size. This workshop will provide an overview of the most general ones and their inclusion in a modular library, and discuss guidelines for the modelling of tumor growth data. It will alternate lectures and hands-on sessions, using real dataset examples to show how to model tumor growth data, including how to choose the model from the library, estimate the parameters and diagnose the model, as well as combining tumor growth data with PK measurements or time-to-event data such as survival. No prior experience of the MonolixSuite is required. Temporary licenses for the MonolixSuite will be provided. More informations and registration here.

  • Lixoft is running a 1 day hands-on workshop on advanced Monolix on Tuesday the 9th of June. The course is designed for modelers with already a good knowledge of Monolix, who wish i) to better understand the methods, the algorithms and their options, ii) learn how to implement complex models, iii) improve their strategy for model building. The course will consist of both lectures and hands-on sessions with Monolix. A dedicated Q&A hour session will be proposed. More informations and registration here.

  • Lixoft is running a 1 day hands-on workshop on quantitative systems pharmacology (QSP) modeling with the MonolixSuite on Tuesday the 9th of June. The MonolixSuite offers an integrated and powerful framework to implement, fit, diagnose and simulate QSP models. The workshop will alternate lectures and hands-on sessions. After an introduction to the goals and advantages of QSP models, the setup of QSP models in Monolix will be explained and exemplified using a representative data set. In the afternoon, participants will have the opportunity to practice the implementation of a QSP model and the estimation of its parameters from clinical data. The calibrated model will finally be used to answer precise research questions via simulations. No prior experience of the MonolixSuite is required. Temporary licenses for the MonolixSuite will be provided. More informations and registration here.

  • Lixoft is running a half-day workshop on Tuesday the 9th of June (afternoon) on advanced simulations with Simulx 2020R1 – a simulation tool equipped with a user friendly graphical interface and fully integrated with all MonolixSuite applications. Thanks to the interactive GUI, modelers interested in performing complex simulations can follow the course without prior knowledge in Monolix and programming. This workshop presents the Simulx interface and typical simulation workflows including: definition of simulation elements, exploration and construction of a study design, simulation of clinical trials and endpoints. Hands-on session focuses on the practical use of Simulx for scenarios starting from simple treatments and going up to complex clinical trials. Temporary licenses for the MonolixSuite are provided. More informations and registration here.

  • Lixoft is running a half-day workshop on non-compartmental (NCA) and compartmental analysis (CA) with PKanalix, a MonolixSuite applications, on Tuesday the 9th of June (morning). It is meant for anyone interested in analysis of PK data sets, bioequivalence assessment and bridging to simulation and pop-PK modelling. No prior experience of the MonolixSuite is required. This workshop presents how to analyse data sets for several typical designs. The main focus is on the NCA and CA workflows, bioequivalence and the connection with the other MonolixSuite applications – all via a user-friendly graphical interface. The hands-on session is to practice exposure analysis, comparison of drug formulations and passage to Monolix for population modelling and Simulx for simulations. Temporary licenses for the MonolixSuite are provided. More informations and registration here.

  • Lixoft is running a 1 day hands-on workshop on the Monolix Suite on Monday the 8th of June. The course is designed for modelers with none to intermediate knowledge of the MonolixSuite. It will present the full modeling and simulation workflow on concrete examples using the 4 applications of the suite: Datxplore for the data visualization, Mlxplore for the exploration of the model behavior, Monolix for parameter estimation and model diagnosis and Simulx for clinical trial simulations. The course will in particular focus on the modeling strategy, the model implementation and the model diagnosis. Two real case studies will be used, covering a PK and a PKPD example of modeling and simulation. More informations and registration here.

  • SGS Exprimo is running a 1-day Clinical Trial Simulation course on Simulo on Monday 8 June. The course will be an introduction to Simulo, an advanced PK-PD model simulator developed for 8 years and now freely available. The participants will get trained, through hands-on exercises, in clinical trial simulations with the aim to evaluate and compare study designs or dosing strategies in an efficient manner. First, they will experience the clear user-interface and the live view which will allow them to import and explore their NONMEM models. Afterwards, they will learn how to build various clinical trial protocols, starting from the most common to the most innovative designs (flexible dose adaptations and complex dosing algorithms). Finally, a focus will be placed on the recently developed Simulo library which facilitates result post-processing and analysis. Cost: 200 EUR for academia/350 EUR for industry to cover the room, lunch and coffee breaks. It includes a 3-month license for Simulo Expert. Only 25 places will be available. For more information and registration, please contact christina.abts@sgs.com. Click here for a more detailed workshop description.
  • esqLABS is running a one-day hands-on PK-Sim® workshop on PBPK on Tuesday, 9th June 2020. Through a combination of lectures and hands-on training, the workshop covers:

    • qualification of PBPK for intended use using the PK-Sim® qualification framework 
    • Age dependency of PK (pediatric PBPK)
    • Analysis of variability within population simulations, and
    • Predicting drug-drug-interactions (DDI)

    While the workshop does not require any prior experience with PK-Sim®, many topics will be of interest even for advanced users. Cost: 400 EUR (+tax) for industry, 300 EUR (+tax) for academia & non-profit and 200 EUR (+tax) for students. esqLABS offers two workshops and a 100€ rebate for registration at both workshops. For more information and registration (select Day 1 for this workshop), please click here.

  • esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on PBPK-based QSP modeling for quantitative integration of PK with PD at the site of action (use-case: ADCs & tumor growth inhibition). The workshop will be held on Saturday, 13th June 2020. Within lectures, demos, and hands-on training, the workshop covers all concepts for combining PK-Sim®, MoBi®, and R to build PBPK-based QSP platforms:

    • integrate PBPK with mechanism-based pharmacodynamics in MoBi®
    • extend the PBPK physiology with customized organs in MoBi®
    • conduct parameter identifications and sensitivity analyses
    • run, plot, and analyze your PBPK-QSP models in R

    While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users. Cost: 400 EUR (+tax) for industry, 300 EUR (+tax) for academia & non-profit and 200 EUR (+tax) for students. esqLABS offers two workshops and a 100€ rebate for registration at both workshops. For more information and registration (select Day 2 for this workshop), please click here

  • Pumas-AI is a organising a workshop on Non-Linear Mixed Effects Modeling with Pumas on Monday and Tuesday 8-9 June 2020. This workshop is designed for beginners and relatively experienced individuals dealing with clinical pharmacology related data analytics in their day to day work. Individuals interested in performing Non-compartmental analysis on their clinical data or use basic or advanced non-linear mixed-effects models to capture the variability in drug pharmacokinetics or response and the contribution of covariate effects and/or simulate new dosing scenarios or clinical trials will find this workshop interesting. Participants with experience in NLME workflows would see the benefit of Pumas workflows over current tools. The agenda for the workshop will be released soon. You can register for the workshop here.

  • Pumas-AI is a organising a workshop on QsP Modeling with Julia and Pumas on Friday and Saturday 12-13 June 2020. Have you been waiting too long for your QSP simulations to finish? Do you want to start making use of advanced modeling features, like stochastic differential equations or partial differential equations? This tutorial will focus on getting users up to speed with using Pumas and Julia's DifferentialEquations.jl for high-performance QSP modeling. The workshop is designed for both beginners and experts alike, allowing them to get acquainted with the differential equation modeling in the Julia language and going to a level of modeling that is appropriate for them. We will start by describing how to define event-driven differential equations in the Julia programming language, and move to showcase how to make use of features like automatic parallelism, global parameter optimization with adjoint sensitivities for fast gradients, and finally advanced model types like stochastic differential equations and differential-algebraic equations. Together, users will get a broad sense of how to implement their QSP models using the Julia programming language in a manner that utilizes the fastest, most parallel, and most expressive set of tools available in the language. The agenda for the workshop will be released soon. You can register for the workshop here.

  • The Pharmainformatics unit of the ATHENA Research and Innovation Center, Athens, Greece will present a one-day workshop on PBPK modelling From Dost’s false hypothesis to the modern era of physiologically based finite time absorption pharmacokinetic (PBFTPK) models on June 9, 2020, 0.9.00-16.00. The following topics will be presented: The development of PBFTPK models, non-existence of flip-flop kinetics, IVIVC and nonlinear IVIVC, inverse Gaussian functions for absorption kinetics, fractal-fractional kinetics, current challenges in PBPK modeling e.g. absorption modeling for inhaled drugs, questioning bioavailability, bioequivalence parameters, and exploring inter-correlation of model parameters. To download the program click here. Cost will be 300 euro for industry, 150 euro for academia/ government/ nonprofit and 100 euro for students for registrations up to 20th of May. Click here to register for the workshop.

  • Metrum Research Group will present a one-day workshop entitled “Flexible and efficient Bayesian pharmacometric data analysis using Torsten” on Tuesday 9 June 2020, 08:00-17:00. We will provide a guided hands-on experience in the use of Torsten for Bayesian pharmacometric modeling with emphasis on models requiring numerical solution of ordinary differential equations (ODEs). Torsten extends Stan, a flexible open-source software platform for Bayesian data analysis, by addition of a library of functions for efficient implementation of pharmacometric models. This workshop builds on the foundations presented in our previous introductory Stan workshops. You will execute Bayesian data analysis examples using Torsten. Via the examples you will learn to implement PK and PKPD models including those involving censoring, numerical solution of ODEs, and user-defined probability distributions and likelihoods. Additional topics will include within-chain parallel computation and use of Stan’s ADVI inference engine for approximate Bayesian analysis. Cost (USD) will be $600 for industry, $300 for academia/government/non-profit and $150 for students. Click here for details and registration.

  • Pharmacodynamic Systems with Delays Research Group will present a one day workshop on Modeling Delays in Pharmacokinetics and Pharmacodynamics using NONMEM on Tuesday the 22th of June. The course will provide an overview of biological systems exhibiting delays, concepts of lifespan driven pharmacodynamic response, modeling of cell maturation, transduction delays, and nonlinear mixed effect lifespan models. Delay differential equations (DDEs) will be introduced and implemented in NONMEM pre-release version 7.5. The course will consist of both lectures and hands-on computer exercises. Source code for DDE based PK/PD models and data will be provided to the participants. Visit this link for more information and registration.

 

SISTER WORKSHOP (PODE2020)

The Workshop on Population Optimum Design of Experiments, PODE 2020, will take place on Monday, June 15, 2020, in Magdeburg, Germany . PODE 2020 will be the 14th workshop in the PODE series which started 2006 at Queen Mary, University of London, under the initiative of Barbara Bogacka and France Mentre, and has been fruitfully continued since then. As in the past PODE 2020 will be an informal one-day workshop, and it will be free of charge for all participants. The workshop will be hosted by the Department of Mathematics at the Otto-von-Guericke University Magdeburg. The aim of this workshop is to bring scientists together who work both on the theory of optimum experimental design for non-linear mixed effects models or its applications in various fields, in particular but not solely, in drug development. Further applications are relevant in item response theory, marketing and agriculture besides others. For more information about the PODE project and previous PODE workshops please see PODE. Further details on PODE 2020 and a tool for registration will be available soon at the workshop website. If you would like to present at the workshop we welcome short abstracts to be sent to the conference organizers via the registration tool by March 31. If you have any questions please do not hesitate to contact pode20@ovgu.de.

 

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