Twenty-ninth meeting, 9 - 12 June, 2020
The PAGE 2020 meeting will be held at the Cankarjev Dom cultural and congress centre, Ljubljana, Slovenia.
Image credit VisitLjubljana.com
Conference location and dates
The PAGE meeting takes place in an informal atmosphere with vivid scientific discussion. PAGE 2020 will be held at the Cankarjev Dom. The meeting starts with a welcome reception at Ljubljana’s Castle on Tuesday evening 9 June. The scientific programme will start on Wednesday morning 10 June and will end at noon on Friday 12 June. Participants are encouraged to attend all conference days and present their work in the form of an oral presentation or poster.
Preliminary programme items:
- The Lewis Sheiner Student Session
The annual Lewis Sheiner Student Session was inaugurated, both to honour the memory of Lewis Sheiner and to highlight his lifetime passion for student education. Students who wish to be considered for this session should submit an extended abstract no later than 28 February 2020 (23:59 PST).
- The abstract must be structured with the following subheadings: Objectives / Methods / Results / Conclusion / References.
- There must be at least 6,000 but not more than 7,000 characters (including spaces) in the abstract text (excluding Title / Authors/ Affiliation and References).
- The submitted work must have been performed either as part of an MSc or PhD programme and/or will ultimately form part of a PhD thesis.
- Each year a rotating committee of three members, representative of the PAGE community, will judge who should receive the honour of presenting in the Lewis Sheiner Student Session.
- If selected, the student will automatically receive a 300€ travel grant. A permanent list of students, with links to their presentation, will be maintained on the web site.
- The Stuart Beal Methodology Session
As a tribute to Stuart Beal, there is a Stuart Beal Methodology Session. The organising committee will choose presenters from the submitted abstracts.
- Tutorial on Competing risks in survival analysis. The lecture will be given jointly by Dr Jason Fine and Dr Andrew Hooker.
- Keynote lecture on Adaptive trial designs: opportunities and challenges. The lecture will be given by Dr Vladimir Dragalin.
PAGE Student Sponsorship
A PAGE Student Sponsorship to support travel and accommodation expenses is available to a number of students unable to obtain any other financial support. This will be judged on a case-by-case basis by a selection committee. Please see here to download a form with criteria and details on how to apply. Applications need to be submitted by the time of the abstract deadline (28 February 2020, 23:59 PST), so make sure you receive confirmation of receipt when sending your application.
Registration opened at this website on Monday 13th January at 09:00 (AM) Ljubljana time (CET). If you want to be kept informed, then update or create your profile.
- Registration is only possible at the PAGE website.
- If you have previously registered at the PAGE website, your personal details (address etc.) are still available.
- If this is the first time you will attend PAGE, register first at the PAGE website before enrolling for the meeting.
Please keep our database up to date by editing your existing profile if required!
- If you've forgotten your password, a reminder can be requested automatically from the website by e-mail.
- If you've forgotten your password and changed your e-mail address then please contact Rik Schoemaker (email@example.com).
- Updates of personal details in the website are confirmed automatically by email. Note that if you do not receive a confirmation, you should check that your e-mail address is correctly entered in the designated field.
Registration fees and payment
- Registration fees are:
- 675 € for participants from industry and commercial enterprises
- 450 € for academics (including post-doc students), non-profit participants, unemployed or retired professionals, and government employees
- 130 € for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do not submit and present a poster or oral communication abstract at PAGE 2020
- 30 € for full time students in an MSc or PhD programme at the time of the PAGE meeting (and not otherwise employed) who do submit and present a poster or oral communication abstract at PAGE 2020
- Fees include coffee, tea and lunch on all days, the welcome reception on 9 June and the social event on 11 June.
- Accompanying persons may attend the welcome reception and the social event for a fee of 130 €
- Participant places are limited and allocated on a first come, first serve basis.
- Registration fees must be paid at the PAGE website by credit card only (Visa, Maestro, MasterCard and American Express) within 14 days after registering at the PAGE website. Failure to meet this deadline will automatically place your registration on the waiting list.
- Students wishing to qualify for the student registration fee will need to upload, at the time of registration, a scanned copy of a signed letter of support from their supervisor indicating that they will be full time students in an MSc or PhD programme at the time of the PAGE meeting, and a scan of their current student card. If this information (and an abstract if applicable) is not available at the time of the abstract deadline (28 February 2020, 23:59 PST), non-reduced fees will be charged.
No refunds will be given once the registration fee has been paid, not even in the extremely unlikely event that the meeting is cancelled due to force majeure. Substitution of delegates will be accepted at any time.
Deadline for Lewis Sheiner Student Session abstracts: FRIDAY 28 FEBRUARY 2020, 23:59 PST
Deadline for regular abstracts: FRIDAY 28 FEBRUARY 2020, 23:59 PST
The abstract submission deadline is the same for all abstracts: Lewis Sheiner Student Session abstracts, oral session abstracts, and poster abstracts and there will be no option for late submissions. In practice, this means that any new abstract entered into the system after 9:00 (AM) CET on Saturday morning 29 February 2020, will be manually removed by the system administrator. The reason is that the PAGE organising committee cares about the quality of all abstracts, and that means that sufficient time is required for judging the abstracts.
- Please follow these instructions carefully regarding format and length of the abstracts or download them in either Word/RTF or Adobe/PDF format. Abstracts that do not comply with these guidelines will not be accepted.
- Each participant is only allowed to submit one abstract, i.e. either in an oral or in a poster category. Please note that requests for an oral presentation usually far exceed the number that can be accommodated in the oral program
- When you click "Submit" you will immediately receive an email with your abstract attached. This e-mail will also be sent to the committee responsible for peer review in the selected category. Therefore, only click "Submit" when you have finished editing and want to submit the final version of your abstract!
- Abstracts will remain invisible until release of the final programme (anticipated date: 15th April)
- Abstracts can be updated up to 1 September 2020
The poster boards will accommodate an A0-size portrait poster (118.9 cm high and 84.1 cm wide/46.8 by 33.1 inches). Material for mounting your poster to the boards will be available on-site.
Software demonstrations and exhibitor spaces
Software companies, Academic Software Application Developers and Contract Research Organisations are welcome to present their products and services during PAGE. The cost for one commercial table is 1700 euros including dedicated high speed wifi connection. Software that is both non-commercial and open-source can be demonstrated without charge. Those interested in this option, please contact firstname.lastname@example.org for further information and booking.
Several events will be held before and after the PAGE meeting. If you are interested in organising such a satellite meeting, please contact the local organising agency AFEA SA at email@example.com. Please note that PAGE itself is not involved in organising satellite workshops or booking venues, etc, and satellite meetings cannot be booked through the PAGE web-site.
Certara UK Limited, Simcyp Division is running a one-day Parameter Estimation and Pharmacodynamics (PE/PD) hands-on workshop on Tuesday 9th June 2020. During the workshop through a combination of lectures and hands-on exercises you will get familiar with the concepts and application of combining the top-down and bottom-up approaches to build fit for purpose PBPK models and the further link PBPK models to PD models to provide insight into covariate impacts on drug response.
The major topics covered are:
- Data entry, fitting and interpretation of results
- Global Sensitivity Analysis of PBPK/PD models
- Simultaneous fitting of PK and PD parameters (at both Population and Individual levels)
- Covariate recognition
- Using built-in and custom scripted pharmacodynamic models in Simcyp
- PD driven by the concentration at the relevant site of action e.g. liver
- The Simcyp R package to run the Simcyp Simulators from R
This course is run using the Amazon Workspaces Cloud Application; please ensure you bring a laptop computer. Cost: Academics and Simcyp Consortium members £300.00, Non Members £400.00. To register please click here or email Kelly at firstname.lastname@example.org.
Certara UK Limited, Simcyp Division is running a one-day Bridging PBPK with POPPK for Paediatrics/Pregnancy workshop on Tuesday 9th June 2020 on predicting the age-related changes to pharmacokinetics and drug-drug interactions including associated variability and linking this information to drug response in the preterm and full term Caucasian and Japanese paediatric populations and pregnant women. Examples of how these can inform the design of POPPK studies will be presented during the course.
The major topics covered are:
- Applications of IVIVE techniques in predicting PK
- Age/gestational-dependent physiological changes and their impact on PK for small and large molecules
- Handling Age- and Time-varying covariates during simulation
- Prediction of DDI in paediatrics
- Linking PK variability to drug response in children
- Strategies for optimal study design using combination of PBPK and POPPK
This course is run using the Amazon Workspaces Cloud Application; please ensure you bring a laptop computer. Cost: Academics and Simcyp Consortium members £300.00, Non Members £400.00. To register please click here or email Kelly at email@example.com.
IntiQuan will present a full-day workshop entitled Advanced QSP Modeling – From Clinical Data to Virtual Subjects, Cohorts, and Populations on Tuesday, June 9, 2020. Special emphasis is put on the estimation of individual parameters based on clinical data, allowing to determine Virtual Subjects, Cohorts, and Populations in an estimation-based approach that is suitable even for large scale models and a large number of subjects in the considered data. The ability to estimate such individual level parameters in QSP models has the potential to open up advances in diagnostics through the use of advanced statistical methods. The cost will be 600 EUR for industry, 300 EUR for academia / government/ non-profit and 100 EUR for students. Click here for details and registration.
IntiQuan will present a full-day workshop entitled Population PK/PD modeling in R on Tuesday, June 9, 2020. The workshop is designed as a hands-on tutorial and focus on PKPD/NLME modeling workflow from data exploration, parameter estimation, and reporting in the R environment using our IQR Tools R package. After the workshop, the participants will be able to set up their own PKPD/NLME workflow using IQR Tools to explore the modeling dataset, perform parameter estimation in supported NLME tools, and evaluate parameter estimation results. Furthermore, participants will be able to generate reports in Microsoft Word directly from the results generated in R. The cost will be 600 EUR for industry, 300 EUR for academia / government/ non-profit and 100 EUR for students. Click here for details and registration.
The xGx/nlmixr/ggPMX team will be offering a one-day workshop entitled An open-source Pharmacometrician’s workflow in R: from data exploration (xGx) to model building (nlmixr) and diagnostics (ggPMX) on Tuesday, June 9, 2020. The workshop consists in presenting three free open-source R packages developed by Novartis:
The participants will have a chance to experience the stepwise framework of the Pharmacometric’s workflow. First, through a question-based approach, xGx helps to uncover useful insights in the data that can be revealed without complex modeling and to identify data aspects that may be explored further. Next, nlmixr is used for building an adequate population model to characterize the dose-exposure-response relationship. Finally, the model evaluation, validation and reporting is supported by ggPMX. Diagnostic plots help assessing the goodness-of-fit of a given model and selecting the model describing the data most accurately. The course will consist of a mixture of lectures and hands-on exercises. For further details and questions on the workshop, please contact Bruno Bieth at firstname.lastname@example.org. For registration, please visit this page. Cost: 150 euros for industry, 100 euros for academia/government/non-profit and 50 euros for students to cover the workshop room, lunch and coffee/tea.
ICON will present a one-day NONMEM 7 course on Monday 8 June. Workshop attendees will be instructed on how to implement the FAST FOCEI algorithm (new in NONMEM 7.4), how to use Monte Carlo importance sampling, stochastic approximation E-M methods, and full Bayesian methods, both traditional Gibbs Bayesian and Hamiltonian no U-turn sampling (new in NONMEM 7.4). Parallel computing and dynamic memory allocation for efficient memory usage will also be described as well as additional new features of NONMEM 7.4. The features of PDx-POP 5.2, the graphical interface for NONMEM 7, will also be demonstrated. Cost will be $500 for industry, $250 for academia, and $100 for students. For details and registration contact Lisa Wilhelm-Lear @ Lisa.Wilhelm@iconplc.com.
Lixoft is running a 1 day hands-on workshop on tumor growth and tumor growth inhibition modeling with the MonolixSuite on Tuesday the 9th of June. A variety of ODE-based models have been published to describe data of longitudinal tumor size. This workshop will provide an overview of the most general ones and their inclusion in a modular library, and discuss guidelines for the modelling of tumor growth data. It will alternate lectures and hands-on sessions, using real dataset examples to show how to model tumor growth data, including how to choose the model from the library, estimate the parameters and diagnose the model, as well as combining tumor growth data with PK measurements or time-to-event data such as survival. No prior experience of the MonolixSuite is required. Temporary licenses for the MonolixSuite will be provided. More informations and registration here.
Lixoft is running a 1 day hands-on workshop on advanced Monolix on Tuesday the 9th of June. The course is designed for modelers with already a good knowledge of Monolix, who wish i) to better understand the methods, the algorithms and their options, ii) learn how to implement complex models, iii) improve their strategy for model building. The course will consist of both lectures and hands-on sessions with Monolix. A dedicated Q&A hour session will be proposed. More informations and registration here.
Lixoft is running a 1 day hands-on workshop on quantitative systems pharmacology (QSP) modeling with the MonolixSuite on Tuesday the 9th of June. The MonolixSuite offers an integrated and powerful framework to implement, fit, diagnose and simulate QSP models. The workshop will alternate lectures and hands-on sessions. After an introduction to the goals and advantages of QSP models, the setup of QSP models in Monolix will be explained and exemplified using a representative data set. In the afternoon, participants will have the opportunity to practice the implementation of a QSP model and the estimation of its parameters from clinical data. The calibrated model will finally be used to answer precise research questions via simulations. No prior experience of the MonolixSuite is required. Temporary licenses for the MonolixSuite will be provided. More informations and registration here.
Lixoft is running a half-day workshop on Tuesday the 9th of June (afternoon) on advanced simulations with Simulx 2020R1 – a simulation tool equipped with a user friendly graphical interface and fully integrated with all MonolixSuite applications. Thanks to the interactive GUI, modelers interested in performing complex simulations can follow the course without prior knowledge in Monolix and programming. This workshop presents the Simulx interface and typical simulation workflows including: definition of simulation elements, exploration and construction of a study design, simulation of clinical trials and endpoints. Hands-on session focuses on the practical use of Simulx for scenarios starting from simple treatments and going up to complex clinical trials. Temporary licenses for the MonolixSuite are provided. More informations and registration here.
Lixoft is running a half-day workshop on non-compartmental (NCA) and compartmental analysis (CA) with PKanalix, a MonolixSuite applications, on Tuesday the 9th of June (morning). It is meant for anyone interested in analysis of PK data sets, bioequivalence assessment and bridging to simulation and pop-PK modelling. No prior experience of the MonolixSuite is required. This workshop presents how to analyse data sets for several typical designs. The main focus is on the NCA and CA workflows, bioequivalence and the connection with the other MonolixSuite applications – all via a user-friendly graphical interface. The hands-on session is to practice exposure analysis, comparison of drug formulations and passage to Monolix for population modelling and Simulx for simulations. Temporary licenses for the MonolixSuite are provided. More informations and registration here.
Lixoft is running a 1 day hands-on workshop on the Monolix Suite on Monday the 8th of June. The course is designed for modelers with none to intermediate knowledge of the MonolixSuite. It will present the full modeling and simulation workflow on concrete examples using the 4 applications of the suite: Datxplore for the data visualization, Mlxplore for the exploration of the model behavior, Monolix for parameter estimation and model diagnosis and Simulx for clinical trial simulations. The course will in particular focus on the modeling strategy, the model implementation and the model diagnosis. Two real case studies will be used, covering a PK and a PKPD example of modeling and simulation. More informations and registration here.
AFEA Travel & Congress Services SA, the official PCO (Professional Congress Organizer), has secured a variety of hotels for the PAGE meeting, which range from luxurious to more standard accommodations at preferential rates. An overview of the hotel accommodation options can be obtained here (early January 2020), and a map with all hotels can be found here (early January 2020). As June is a high season in Ljubljana, and rooms will be booked on a first-come first serve basis, we kindly advise all the delegates to proceed with their bookings well in advance.
Room reservation process
Should you wish to register online, please use this link. For group reservations (over 10 rooms), please contact the Booking Secretariat directly at Accomodation_PAGE2020@afea.gr. A confirmation letter for your reservation will be sent automatically to your email account. Should you not receive a confirmation letter, please contact the Professional Congress Organizer (see below). Rooms have been pre-booked in all the hotels until February 28th 2020 and will be confirmed on a first-come first-served basis as they are subject to availability. After this date, all reservations will be handled upon request.
Payment and Cancellation policy for Accommodation
- Full settlement of the accommodation cost is required, in order for the room reservation to be confirmed.
- For any cancellation sent in writing, until March 11th, 2020, 30% cancellation fees will apply.
- For any cancellation sent in writing, from March 12th until April 15th, 2020, 50% cancellation fees will apply.
- After this date, full cancellation fees will apply. Any reduction in nights will be treated as a cancellation and no refund will be possible.
If Vienna and Prague got married and had a baby, then this would certainly be LJUBLJANA (...but, with its Mediterranean flair, we might assume that an Italian lover was hiding in the bedroom...). Ljubljana, the capital of Slovenia, lies between Vienna and Venice, not far away from the Adriatic Sea. Its city region has always lain at the intersection of important transport routes leading from northern Europe to the Adriatic Sea and from western to eastern Europe and further on to the Balkans and the Near East. Road and rail connections have traditionally been good. Not far from the city is Ljubljana Jože Pucnik Airport, the country's main airport. Ljubljana (pop. 293,000) is one of the smallest European capitals. It’s never crowded – but also never boring. 50,000 university students give it its youthful appeal, and as an economic and cultural hub of Slovenia, it has a lot to offer to locals and visitors alike.
- An exciting mix of different cultural traditions
- One of Europe's top new culinary destinations
- A city with a green soul
- The perfect conference and congress city
- Unforgettable events and venues
Slovenia (and Ljubljana) was in 2014 proclaimed Lonely Planet‘s Best Place in Europe and one of Europe‘s most idyllic places to live by Forbes in 2008. Ljubljana is already one of Europe’s greenest and most livable cities, boasting a friendly café culture by day, and vibrant nightlife after the sun sets. Slovenia, which is as picture-perfect as Switzerland but much easier on the wallet.
Ljubljana is the European Green Capital 2016
Since Ljubljana is a very green city, with the main park touching the city centre, and Slovenians are in general very fond of nature, the outdoor space and recreation, a lot of possibilities for recharging batteries are available. Both Slovenia and Ljubljana are regarded as very safe destinations.
Visa requirements and letters of invitation
Slovenia entered the Schengen Agreement in 2007 and thus EU citizens do not require a visa to enter Slovenia, a passport or ID card is sufficient. Non-EU citizens are kindly advised to check the requirements at the website of the Slovenian Ministry of Foreign Affairs. It is recommended to begin the visa application procedure two months before the travel date. CD Congress Centre Ljubljana can handle the procedure of guarantee letters, requiring a one-week time frame and costing EUR 12 per document. Additional information on requesting a letter of guarantee for the visa process can be found in the document that you can download using this link.
ACCESS TO LJUBLJANA
Ljubljana Jože Pucnik Airport is located 26 kilometres to Ljubljana (20 minutes by road). W: https://www.fraport-slovenija.si/en/Main
Transfers to/from the airport
- Shuttle transfers: GoOpti, Nomago, MNJ Shuttle, Markun Shuttle, ZUP prevozi.
- Taxi: Taxi services are available in front of the airport building.
- Rent-a-car: consult the list of rent-a-car service providers at the airport.
Regular bus route
A regular bus route connects the Ljubljana Jože Pucnik Airport and the Ljubljana Central Bus Station (bus stop no. 28)
The distances to the other airports:
- Airport Graz, Austria: 187 km
- Airport Klagenfurt, Austria: 85 km
- Airport Zagreb, Croatia: 140 km
- Airport Trieste, Italy: 130 km
- Airport Venice, Italy: 230 km
- For transfers to Ljubljana consider shuttle transfers above.
Ljubljana is located at the crossroads of Slovenia's most important road routes. Motorway access from any of the neighbouring countries is very easy.
Road tax vignettes must be purchased for the use of Slovenian motorways, including the Ljubljana bypass. The roads where the vignette is required are marked by special vignette signs. Vignettes can be purchased at petrol stations located in the border areas of Slovenia's neighbouring countries, at petrol stations, post offices and most newspaper kiosks in Slovenia, and at branch offices of the Automobile Association of Slovenia (AMZS) and other automobile clubs.
The Ljubljana Railway Station is Slovenia's main railway station. It connects Ljubljana to Trieste, Frankfurt, Munich, Zurich, Prague, Vienna, Graz, Budapest, Zagreb, and Belgrade. Railway is also a convenient means of transport within Slovenia, given that distances within the country are mainly short and travel costs low. W: https://www.slo-zeleznice.si/en/
The Ljubljana Bus Station has regular services to all Slovenia's neighbouring countries and the most popular tourist destinations within the country. Bus tickets can be purchased at the counter of the Ljubljana Bus Station or online from the Ljubljana Bus Station website. European cities served by direct bus routes from Ljubljana: Trieste, Venice (Mestre, Marco Polo Airport), Florence, Milan, Klagenfurt, Vienna, Munich, Dortmund, Paris, Budapest, Zagreb, Sarajevo, Belgrade, Niš, Sofia. W: https://www.ap-ljubljana.si/en/
Green means of transportation are encouraged. For example, you could use a train to travel from Munich to Ljubljana (6 hours, approx. €30 one-way, €80 bed in a 3-bed compartment, 0.005 tonnes of CO2) instead of a plane (1 hour flight, 0.045 tonnes of CO2).
TRANSPORT IN LJUBLJANA
Those wishing to travel on Ljubljana city buses, operated by the Ljubljanski potniški promet (LPP) public utility company, should purchase the Urbana public transport card. The bus fare is paid via the Urbana stored-value card (card price €2.00 + bus fare). One bus fare equals €1.20. Changing buses within 90 minutes from purchase is free-of-charge. Ljubljana Tourist Card: Free-of-charge LPP bus fares during the entire period of the card’s validity (24, 48 or 72 hours).
BicikeLJ bicycle-sharing system
The BicikeLJ public bicycle system is available across the wider Ljubljana city centre. Bicycles can be hired practically for free.
In the summer and early autumn months (1 April - 31 October), bicycles can be hired in the Ljubljana Bike project, led by the Ljubljana Tourism.
In the centre of Ljubljana you can easily find a vacant taxi. Charges range between €0.80 and €1.50 for the starting fee and from €0.70 to €1.70 per kilometre. A taxi ride from Ljubljana Jože Pucnik Airport to Ljubljana costs from €20.00 to €45.00. Charges are lower when taxis are ordered by phone. In any case, it is advisable to enquire about the fare before the ride.
Slovenia: UTC +1, CET (Central European Time)
The climate of Slovenia is influenced by the Alps and the Mediterranean, except for its north-eastern part which is mostly continental. Ljubljana typically has cool and humid winters, while summers are warm and sunny thanks to Mediterranean air currents. The average low and high temperatures for June range from 12 to 23° C.
Foreign exchange, banking facilities
The Slovenian currency is the Euro (€). Most stores accept international credit and payment cards. There is also a wide network of ATMs where you can withdraw cash.
WiFree Ljubljana – city Wi-Fi network
WiFree Ljubljana offers 60 minutes of free Internet access in the direct city centre. The network can be accessed following a registration at www.wifreeljubljana.si.
Ljubljana Card: Free-of-charge 24-hour Internet access. The access to www.visitljubljana.com and other municipal websites is unrestricted.
Country code: +386 – Slovenia
Regional code: 01 – Ljubljana
Shopping in Ljubljana
The majority of shops in the city centre of Ljubljana are open between Monday and Friday from 8.00am to 7.00pm, Saturday from 8.00am to 1.00pm. The shopping centres at the city’s outskirts are open between Monday and Saturday from 8.00am to 9.00pm, Sunday from 8.00am to 3.00pm.
112 Emergency telephone number: fire and rescue, ambulance
1987 Traffic information – AMZS Road Assistance
Ljubljana Tourist Information Centre. W: https://www.visitljubljana.com/en/visitors/
AFEA S.A. Booking Secretariat
Professional Congress Organizer
39-41 Lykavittou Street
10672 Athens, Greece
Tel: +30 2103668853 (direct line)
Fax: +30 2103643511
For matters related to payment of registration fees and abstracts: