2008 - Marseille - France

2008 - Marseille - France

Wednesday June 18
08:00-09:00 Registration
09:00-09:15 Welcome and Introduction
09:15-10:15 Oncology Session (invited speakers)

chair: René Bruno

09:15-09:45 Joga Gobburu The strategic use of modeling and simulation in oncology
09:45-10:15 Alwin Huitema Application of modelling and simulation in clinical oncology
10:15-10:20 Charlotte Kloft: Launch of the Graduate Research Training (GRT) Program 'Pharmacometrics & Computational Disease Modelling' in Germany
10:20-11:50 Coffee break, Poster and Software session I
  Posters in Group I are accompanied by their presenter
11:50-12:30 Oral session continued (submitted abstracts) chair: Dinesh de Alwis
11:50-12:10 Laurent Claret A modeling framework to simulate Xeloda dose intensity and survival in colorectal cancer
12:10-12:30 Ines Paule Model-based dose adaptation of capecitabine for prevention of severe hand-and-foot syndrome: in silico comparison with the standard method
12:30-14:00 Lunch
14:00-15:00 Mats Karlsson and Nick Holford: A Tutorial on Visual Predictive Checks with a link to the pdf of the presentation
15:00-16:30 Tea break, Poster and Software session II
  Posters in Group II are accompanied by their presenter
16:30-17:30 Methodology/Applications chair: Oscar Della Pasqua
16:30-16:50 Eric Snoeck The challenge of modelling hepatitis C virus dynamics after long term treatment: Application of MONOLIX
16:50-17:10 Søren Klim Deconvolution of Insulin Secretion Rates
17:10-17:30 Lena Friberg Modeling and Simulation of the Asenapine Exposure-Response and Drop-Out in Acute Schizophrenia
Thursday June 19
09:00-10:20 Lewis Sheiner Student Session

chair: Silvy Laporte, Janet Wade and Stephen Duffull

09:00-09:25 Martin Bergstrand Modeling of gastro-intestinal tablet transit and its' effect on drug release and absorption for felodipine extended release tablet under fed or fasting conditions
09:25-09:50 Jakob Ribbing Modelling the Dynamics of Glucose, Insulin, Insulin Sensitivity and Beta-Cells in Subjects with Insulin Resistance and Patients with Type 2 Diabetes
09:50-10:15 Thuy Vu Time Course of Disease Status as a Predictor of Clinical Outcome in Parkinson's Disease
10:15-10:20 Presentation of Awards  
10:20-11:50 Coffee break, Poster and Software session III
  Posters in Group III are accompanied by their presenter
11:50-12:30 Applications chair: Charlotte Kloft
11:50-12:10 Michael Barras Individualized compared with conventional dosing of enoxaparin.
12:10-12:30 Marilee Andrew Effect of Cranberry Juice on Population Pharmacokinetics of Amoxicillin and Cefaclor
12:30-14:00 Lunch
14:00-15:00 Meindert Danhof and Bart Ploeger: Tutorial on Implementing Receptor Theory in PK-PD Modeling
15:00-16:30 Tea break, Poster and Software session IV
  Posters in Group IV are accompanied by their presenter
16:30-17:30 Stuart Beal Methodology Session chair: France Mentré
16:30-16:50 Andrew Hooker Parameter estimation in non-linear mixed effects models using interval analysis
16:50-17:10 Christian Laveille Evaluation of the PK and PK-PD libraries of MONOLIX: A comparison with NONMEM
17:10-17:30 Elodie Plan Maximum Likelihood Estimation Methods: Performances in Count Response Models Population Parameters
19:00-24:00 Social evening
Friday June 20
09:00-10:00 Methodology: Design chair: Stephen Duffull
09:00-09:20 Joakim Nyberg Application of the optimal design approach to improve therapeutic drug monitoring for cyclosporine
09:20-09:40 Sylvie Retout Design optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics
09:40-10:00 Sergei Leonov Stochastic pharmacokinetic models: selection of sampling times
10:00-10:30 Coffee Break
10:30-11:30 Stuck in Modelling chair: Mats Karlsson, Iñaki Trocóniz, Stephen Duffull
10:30-11:00 Anthe Zandvliet PK-PD model of multiple follicular development with corifollitropin alfa during controlled ovarian stimulation: application of Markovian elements.
11:00-11:30 Nick Holford Attempts to describe disease progress and the action of oral hypoglycaemic agents in type 2 diabetes
11:30-11:40 Preview of PAGE 2009
11:40-12:20 Applications chair: Nick Holford
11:40-12:00 Joe Standing Predicting Paediatric Tobramycin Pharmacokinetics with Five Different Methods
12:00-12:20 Stephen Duffull A system model for the clotting cascade challenges clinical management of snake bites
12:20-12:30 Closing Remarks
12:30-12:45 Audience Input for the PAGE 2009 Program


All oral abstracts can be downloaded as a single document (rtf or pdf) and all poster abstracts can be downloaded as a single document (rtf or pdf).

Software demonstrations: Commercial

Pharsight: Phoenix platform, WinNonlin, Trial Simulator, WinNonlin AutoPilot, and PKS (a PK/PD data repository)
ICON Development Solutions: Hands-On Demonstration of PDx-Pop® v3.0; Tools for Expediting Population Analysis
Simcyp: Simcyp Simulator - a comprehensive platform and database for mechanistic modelling and simulation of oral drug absorption, tissue distribution, metabolism and elimination in healthy and disease populations using in vitro knowledge 
GastroPlus: GastroPlus
Mango Solutions:Mango Solutions
PK-Sim:Hands-On Demonstrations of the Physiology-Based Pharmacokinetic Software, PK-Sim®

Software demonstrations: Non-commercial 

Carlos Hoyo-Vadillo Four Programs for Writing and Running Nonmem Scripts
Roger Jelliffe The USC*PACK software for nonparametric adaptive grid (NPAG) population PK/PD modeling, and the MM-USCPACK clinical software for individualized drug regimens
Saik Urien RfN, R for Nonmem: A graphical interface for Nonmem outputs
Rich Haney Open Statistical Services
Andrew Hooker PopED
Andrew Hooker Xpose and Perl speaks NONMEM(PsN)
Marc Lavielle Analysing population PK/PD data with MONOLIX 2.4 and writing complex models with MLXTRAN

Posters Wednesday Morning (group I)

Applications- Other topics

Corina Becker Whole-Body Physiologically-based Pharmacokinetic (WB-PBPK) Population Modelling to Simulate the Influence of Weight and Age on the Pharmacokinetics (PK) of a combined Oral Contraceptive Containing Drospirenone (DRSP) and Ethinylestradiol (EE)
Misba Beerahee Clinical Trial Simulation to Estimate the Sample Size for Investigation of the Impact of a Drug A on the Pharmacokinetics of Methotrexate, a common co-medication used in Rheumatoid Arthritis (RA) 
Pascal Chanu Decisive support of Modeling & Simulation for getting drug approval in the context of safety concern on the drug class
Chao Chen Population PK/PD modelling of functional receptor occupancy in a first-time-in human study
Emmanuelle Comets Modelling is seldom used to describe pharmacokinetics in phase I clinical trials
Mike Dunlavey Simplified programming of population model user interfaces
Yumi Emoto Evaluation of Population PK/PD for Osteoporosis during a Vitamin D3 (1,25(OH)2D3) Derivative Therapy
Samuel Fanta Population Pharmacokinetics of Cyclosporine in Paediatric Renal Transplant Recipients
Dymphy Huntjens Receptor-mediated pharmacokinetic modeling of a novel anti-epileptic drug in healthy volunteers
Daniel Jonker The pharmacokinetics of the once-daily human glucagon-like peptide-1 analogue, liraglutide, across 5 trials in healthy subjects and type 2 diabetics after single and multiple dosing
Catherijne Knibbe Predictive Value of Allometric Scaling for Estimation of Propofol Clearance in Neonates, Infants and Adolescents
Elke Krekels Development AND External validation of a model for Glucuronidation in children below 3 years of age using morphine as a model drug; towards a novel dosing paradigm.
Glynn Morrish Using Body Composition Metrics to Predict Exposure Between Japanese and Caucasian Populations
Flora Musuamba-Tshinanu Limited sampling formulas and bayesian estimation for mycophenolic acid 12 hours Area Under the concentration-time Curve prediction in Stable renal transplant recipients co-medicated with cyclosporine or sirolimus
Rogier Press Optimizing Calcineurin Inhibitor Exposure In De Novo Kidney Transplant Recipients
Jean Smeets A Mechanism-based Pharmacokinetic Model Describing the Interaction Between Sugammadex and Rocuronium in Patients with Normal and Impaired Renal Function
Tamara van Steeg Assessment of the use of complex baseline models in preclinical safety screening: Application of the van der Pol oscillator model to describe heart rate effects in rats
Johan Wallin Population pharmacokinetics of tacrolimus in paediatric bone marrow transplant recipients
Susan Willavize Dose Selection for Combination Drug Products
Susan Willavize Using M&S to Shorten the Repeating Cycle of the Early Drug Development Process: A Case Study

Methodology- Other topics

Paul Baverel Covariate Model Building Method for Nonparametric Estimation Method in NONMEM VI: Application to Simulated Data
Martin Boucher A Bayesian Meta-Analysis of Longitudinal Data in Placebo Controlled Studies with Naproxen
Marylore Chenel How to show average bioequivalence of concentrations in a test sample with a reference population pharmacokinetic model?
Cian Costello A Time Scaling Approach to Develop an In Vitro-In Vivo Correlation (IVIVC) Model Using a Convolution-Based Technique
Ekaterina Gibiansky Indirect Response Models with Positive Feedback: Equations, Properties, and Possible Applications
Andreas Velsing Groth Alternative parameterisations of saturable (Emax) models allowing for nesting of non-saturable models
Emilie Henin Patient compliance estimated from pharmacokinetic sample: application to Imatinib
Matt Hutmacher Implications for animal-human scaling of the parallel elimination profile PK model
Ibrahim Ince Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling
Ron Keizer A simple infrastructure and graphical user interface (GUI) for distributed NONMEM analysis on standard network environments
Charlotte Kloft Launch of the Graduate Research Training (GRT) Program 'Pharmacometrics & Computational Disease Modelling' in Germany
Ricardo Nalda-Molina Pharmacokinetic and Pharmacodynamic Model for Drug Induced Transient Transaminitis
Carmen Navarro Estimating the complete AUC and its standard error in sparse sampling designs.
Klas Petersson Transforming parts of a differential equations system to difference equations as a method for run-time savings in NONMEM VI
Angelica Quartino Comparison Between using Continuous and Categorical Toxicity Data for Estimation with a Model for Continuous Data 
Radojka Savic A novel bootstrap method for obtaining uncertainty measurement around the nonparametric distribution
Nabil Semmar Independent-model diagnostics for a priori identification and interpretation of outliers from a full pharmacokinetic database: correspondence analysis, Mahalanobis distance and Andrews curves
Steven Xu Exposure-Response Analysis of Adverse Events in Clinical Trials Using Zero-Inflated Poisson Modeling With NONMEM®.


Posters Wednesday Afternoon (group II)

Applications- Anti-infectives

Caroline Bazzoli Population pharmacokinetics of AZT and its active metabolite AZT-TP in HIV patients: joint modelling and design optimisation
Helena Colom Population pharmacokinetics of Ganciclovir following Valganciclovir in solid organ transplant recipients infected by cytomegalovirus
Anne Dubois Population analysis of plasma and intracellular pharmacokinetics of indinavir in HIV-1 infected patients with a stable antiretroviral therapy
Monika Frank Nevirapine - Population pharmacokinetic model building and simulation for mothers and newborns
Maria Jose García Population Pharmacokinetics of Efavirenz in HIV-infected patients: Pharmacogenetic analysis
Sylvain Goutelle A Population Pharmacokinetic Study of Plasma and Intrapulmonary Concentrations of Rifampin
Sylvain Goutelle Influence of Rifampin Pharmacokinetic Variability on Antibacterial Effect and Prevention of Resistance in Pulmonary Tuberculosis: a Simulation Study
Flora Musuamba-Tshinanu Simultaneous Therapeutic Drug Monitoring Of Amikacin And Beta-Lactams In Intensive Care Unit Patients With Severe Sepsis Or Septic Shock Without Beta-Lactam Serum Concentration Monitoring
Partha Nandy Relationship Between a PK/PD Parameter and Therapeutic Response of Ceftobiprole in Patients with Complicate Skin and Skin Structure Infection
Michael Neely Population Kinetics and Dynamics of Lopinavir in HIV-Infected Children
Elisabet Nielsen Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates: Modelling and Simulation Based on Data from a Prospective Study
Daniel Röshammar Population Pharmacokinetics of Efavirenz and MDR-1, CY2B6, and CYP3A5 Polymorphisms
Catherine Mary Turner Sherwin Simulation and development of a netilmicin extended dosing regimen for extremely premature neonates.
Nicolas Simon Population Pharmacokinetics of Atazanavir in HIV-infected Patients
Joel Tarning Population pharmacokinetics of lumefantrine in pregnant women treated with co-artemether for uncomplicated falciparum malaria
Jan-Stefan van der Walt Population pharmacokinetic models for lamivudine and nevirapine to assess drug concentrations obtained during therapeutic drug monitoring
Wei Zhao Population Pharmacokinetics of Ganciclovir Following Oral Administration of its Prodrug Valganciclovir in Pediatric Renal Transplant Patients

Applications- Coagulation

Xavier Delavenne Assessment of pharmacokinetic variability of fondaparinux in 809 patients treated after major orthopedic surgery: the POP-A-RIX study

Methodology- Design

Massimo Cella Randomisation to exposure in early paediatric trials: an analysis on the influence of the dose on the heterogeneity in the response to abacavir.
Marylore Chenel Optimal design of QTc interval measurements for circadian rhythm determination
Marion Dehez Optimal window design of blood pressure time measurements in hypertensive dippers and non-dippers using ABPM: Application of the compound D-optimality approach.
Phey Yen Han Informative Study Designs to Identify True Parameter-Covariate Relationships
Joakim Nyberg Application of Optimal Design for Disease Progression Studies
Tracy Higgins Simulation and Design Considerations for Noninferiority Trials in Phase II
Hyung Ki Kim The Effect of Study Design on Pharmacokinetics in Patients with Impaired Renal Function
Rocio Lledo Impact of study design for characterising PKPD covariance and nonlinearity in exposure-dichotomous response relationships
Rocio Lledo Randomised dose controlled trials or concentration controlled trials when learning about drugs with narrow therapeutic index?
Mark Lovern Development of a Bayesian Adaptive Sampling Time strategy for PK studies with constrained number of samples to ensure accurate estimates.
Mark Lovern Leveraging complicated PK/PD models for the development of a Bayesian adaptive Dose-ranging design.
Guy Meno-Tetang The Use of Clinical Trial Simulation to investigate Bias in Crossover Studies with a Short Washout Period and no Placebo Arm: Application to Neuropathic Pain
Joakim Nyberg Dose and sample time optimization of drug candidate screening experiments
Kayode Ogungbenro An Effective approach for Obtaining Optimal Sampling Windows for Population Pharmacokinetic Experiments
Italo Poggesi Evaluation of direct population PKPD models for truncated concentration-response curves
Alberto Russu Dose escalation studies: a comparison between NONMEM and a novel Bayesian tool
David Salinger Mean Squared Error as Criterion for Sampling Schedule Optimization for Individual Dose Targeting in IV Busulfan
Hanna Silber Improvement of the intravenous glucose tolerance test using optimal experimental design.
Stefano Zamuner Adaptive Optimal Design in PET Occupancy Studies


Posters Thursday Morning (group III)

Methodology- Algorithms

Julie Antic Some Stochastic Algorithms For The Smooth Non Parametric (SNP) Estimator
Julie Bertrand Properties of different tests to detect the effect of a genetic covariate on pharmacokinetic parameters using the SAEM algorithm for several designs
Vivek Dua Automatic Selection of Optimal Configuration of Artificial Neural Networks
Clare Gaynor A Differential Equations Approach to In Vitro - In Vivo Correlation Modelling in NONMEM
Leonid Gibiansky Parameter Estimates of Population Models: Comparison of Nonmem Versions and Estimation Methods
Leonid Gibiansky Approximations of the Target-Mediated Disposition Model and Identifiability of Model Parameters
Leonid Gibiansky Application of Identifiability Analysis Algorithm to Population PK of the Drug with Target-Mediated Disposition
Søren Klim Linear Mixed Effects models based on Stochastic Differential Equations in R
François Mercier Simulation and evaluation of bivariate Beta distribution for interval response variables
Benjamin Ribba Monolix benefits from external modules to manage complex ODE: Illustration with a population analysis of Irinotecan and its metabolites.
Rich Haney Accelerating the Rate of Adoption of New Pharmacometrics Platforms Using Formal Tools for Model Interconversion

Applications- Biologicals/vaccines

Daren Austin Use of mechanistic models to estimate target antigen load for monoclonal antibodies
Brigitte Lacroix
Exposure-response analysis of certolizumab pegol in Crohn's disease population
Brigitte Lacroix
Exposure-Response Modeling of the ACR20 Score in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol
Micha Levi Relationship Between Serum Concentration of the Interleukin-6 Receptor Inhibitor, Tocilizumab (TCZ), and Disease Activity Score (DAS28) in Patients with Rheumatoid Arthritis
Etienne Pigeolet Granulocyte Colony Stimulating Factor Pharmacokinetics After Single and Repeated Administration of Several Doses.
David Ternant Development of anti-infliximab antibodies increases infliximab clearance in inflammatory bowel diseases
Justin Wilkins Bioequivalence, bootstrapping and case-deletion diagnostics in a biologic: a model-based analysis of the effect of formulation differences in a monoclonal antibody

Applications- CNS

Aliénor Bergès Using VT (total volume of distribution from PET) in estimating the PK-Receptor Occupancy relationship in the absence of reference regions
Chao Chen Population modeling of the relationship between ropinirole systemic exposure and efficacy in Parkinson's disease
Rik de Greef Modeling and Simulation to Integrate Efficacy and Safety Data Following Full Development: a Case Study in Schizophrenia and Bipolar Disorder
Geraldine Ferron PK and PK/PD modeling of CB1 blocker antagonism of THC induced CNS and Heart Rate effect
Sophie Gisbert Analysing Raw Count data from an In Vitro Target Occupancy Assay to Select Doses for Human Safety/Tolerability Trial
Dymphy Huntjens PK/PD modeling of apomorphine-induced behaviour in macaques
Brigitte Lacroix Population Pharmacokinetics of Brivaracetam in Patients with Partial Epilepsy
Bart Laurijssens Model-Based Analysis of a Longitudinal Binary Response as the Primary Analysis for a Phase II Study in Migraine Prophylaxis.
Otilia Lillin-de Vries A population analysis on the effects of the CYP2D6 deficiency on pharmacokinetics and exposure of esmirtazapine in healthy volunteers.
Igor Locatelli Population Pharmacokinetics of Risperidone in Patients with Acute Schizophrenia
Guangli Ma Pool Model versus Agonist-Antagonist Interaction Model for the Remoxipride Effect on Prolactin
Sarah McLeay Scaling propofol doses for the obese: is lean body weight the answer?
Raymond Miller Exposure-Response Analysis of Longitudinal Adverse Event Data.
Gianluca Nucci A sparse sample PK/PKPD approach to estimate the time course of antipsychotic-induced D2 occupancy
Elba Romero Extended Link Model to Describe the Impact of Chronic Antiepileptic Therapy on the Effects of Neuromuscular Blocking Agents.
Monica Simeoni Modelling beta amyloid system: sensitivity analysis at steady state and in dynamic conditions.
Armel Stockis Levetiracetam exposure-response analysis in children with partial onset seizures
Katarina Vucicevic Estimation of Relative Bioavailability of Controlled-Release Carbamazepine Tablets Based on Routine TDM Data
Stefano Zamuner Mixed Effects Markov Models for Modelling Sleep in Insomniac Patients Treated with Placebo in a 28 Days Trial: Emphasis on the Break Points Selection


Posters Thursday Afternoon (group IV)

Applications- CVS

Massimiliano Germani Nonparametric Modeling and Population Approach to the Individualized Heart Rate Correction of the QT Interval
Ihab Girgis Bayesian Modeling of QT Measurements: Focus on Baseline QTc 
Carlos Hoyo-Vadillo Pharmacokinetics model for Nifedipine administered to Healthy Volunteers.
Kevin Krudys Bridging Cardiovascular Risk from Clinical Trials to Real Life Population

Applications- Endocrine

Paolo Denti Comparison of Different Population Analysis Approaches to the IVGTT Glucose Minimal Model
Silke Dittberner Target mediated drug disposition model for the DPP-4 inhibitor BI1356 (proposed trade name ONDERO): Is the structure identifiable?
Silke Dittberner BI 1356 (proposed trade name ONDERO) pharmacokinetics and DPP-4 inhibition: Development of a target mediated PKPD model in type 2 diabetic patients
Maria Garrido Simultaneous population pharmacodynamic modelling of the growth hormone and insulin-like growth factor-I effects after deep subcutaneous administration of Lanreotide Autogel® in acromegalic patients. Application of Nonparametric estimation method in NONME
Cyrus Ghobadi Pharmacokinetics of oral single-dose clomiphene citrate (CC) in polycystic ovary patient with anovulatory infertility
Tae Han Alteration of glucose and insulin regulatory networks for the treatment of type 2 diabetes mellitus
Nick Holford Delayed response to hypoglycaemic agents and effect on progression of type 2 diabetes
Petra Jauslin Identification of the Mechanism of Action of a Glucokinase Activator from OGTT Data in Type 2 Diabetics Using an Integrated Glucose-Insulin Model
Teun Post Disease System for osteoporosis: relating bone mineral density with measures of bone formation and resorption based on bone biology
Rujia Xie Model-Based Drug Development (MBDD) of Pegylated Growth Hormone (PEG-hGH) in the Treatment of Adult Growth Hormone Deficient (AGHD)
Rujia Xie Relationship between the Dose of Recombinant Human Growth Hormone (rhGH) and Insulin Growth Factor-1 (IGF-1) in Adult Patients with Growth Hormone Deficiency (AGHD)

Applications- Oncology

René Bruno Modeling and simulation to assess the use of change in tumor size as primary endpoint in Phase II studies in oncology
Antonin Schmitt External validation of a model based on cystatin C to predict carboplatin clearance
Francesca del Bene Evaluating the Influence of Different Sources of Variability in the PK/PD Tumor Growth Inhibition (TGI) Model
Nicolas Frances Modeling of longitudinal tumor size data in clinical oncology studies of drugs in combination
Lena Friberg Scaling the Time-Course of Myelosuppression from Rats to Patients with a Semi-Physiological Model
Maria Garrido Biopharmaceutic and pharmacodynamic characterization of the in vitro anti-proliferative effect of new delivery systems of Cisplatin
Massimiliano Germani Evaluating the Influence of Different Sources of Variability in the PK/PD Tumor Growth Inhibition (TGI) Model
Emma Hansson The Shape of the Myelosuppression Time-course is Related to the Probability of Developing Neutropenic Fever in Patients with Docetaxel-induced Grade IV Neutropenia
Emma Hansson Comparison of Inter-Occasion and Inter-Individual Variability in Chemotherapy- Induced Myelosuppression
Ron Keizer Population PK-PD modeling of E7820 and ±2-integrin expression on platelets in patients with solid tumors and lymphomas
Stijn Koolen Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer
Katharina Küster Matuzumab - Evaluation of the Population Pharmacokinetic Model and Analyses of the Covariate Impact on the Pharmacokinetic Profile
Andreas Lindauer Population Pharmacokinetics of High-dose Carboplatin
Elena Soto A semi-mechanistic population pharmacokinetic/pharmacodynamic model for neutropenia following therapy with the new PLK-1 inhibitor BI 2536 and its application in clinical development
Kellie Turner Reduced Folate Carrier Single Nucleotide Polymorphism Associated with Methotrexate Clearance in Breast Cancer Patients

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Methodology- Model evaluation

Robert Bies A comparison of a genetic algorithm based automated search algorithm to standard stepwise approach for population pharmacokinetics using NONMEM.
Carlos Fernandez-Teruel Simulations of bioequivalence trials using physiological-pharmacokinetic in single dose and steady state scenarios. Which scenarios are refusable?
Laura Iavarone A Population PK model to evaluate variability in oral absorption using gamma scintigraphy
Robert Leary Nonparametric Analogs to POSTHOC Estimates for Exploratory Data Analysis
Gianluca Nucci Modelling and Simulation of Ketoconazole inhibition when co-administration time is not sufficient: role of CYP3A function recovery

Methodology- PBPK

Viera Lukacova PBPK modeling of metoprolol and its metabolites
Italo Poggesi Evaluation of a basic PBPK model in preclinical species for which tissue compositions are unknown