abstracts-archive - PAGE Meeting (Population Approach Group Europe)

Abstracts found: 6777

Modeling the influence of antiretroviral treatment initiation time on post-treatment control of HIV infection

Abstract number: 11145

Bharadwaj Vemparala (1), Caroline Passaes (2, 3), Delphine Desjardins (4), Anaïs Chapel (2, 3), Valérie Monceaux (2, 3), Julien Lemaitre (4), Adeline Mélard (5), Federico Perdomo-Celis (3), Cyril Planchais (6), Maël Gourvès (2), Nastasia Dimant (4), Annie David (3), Nathalie Dereuddre-Bosquet (4), Aurélie Barrail-Tran (4, 7), Hélène Gouget (4), Céline Guillaume (4), Francis Relouzat (4), Olivier Lambotte (4, 8), Michaela Müller-Trutwin (3), Hugo Mouquet (6), Christine Rouzioux (9), Véronique Avettand-Fenoël (5, 10), Roger Le Grand (4), Asier Sáez-Cirión (2, 3), Narendra M Dixit (1, 11), Jérémie Guedj (12)

2024 - Rome - Italy

Using Fisher Information Matrix to predict covariate effects in forest plots and power of their relevance

Abstract number: 10956

Lucie Fayette (1,2), Karl Brendel (2), France Mentré (1)

2024 - Rome - Italy

Physiologically Based Pharmacokinetic modelling of the Drug-Drug Interaction between Ivacaftor and Lefamulin in Cystic Fibrosis patients

Abstract number: 10836

Magali Amiel; Alice Ke; Steven P. Gelone; Hannah M. Jones; Wolfgang Wicha

2024 - Rome - Italy

Physiologically based pharmacokinetic modelling to predict the concentration-time profile of an antibody-drug conjugate and hepatic and renal impairment.

Abstract number: 10926

Felix Stader, Cong Liu, Adriana Zyla, Abdallah Derbalah, Armin Sepp

2024 - Rome - Italy

Modelling antibody levels impact on infection and SARS-CoV2 replication

Abstract number: 11126

Adrien Mitard (1,2), Cécile Hérate (3), Nathalie Dereuddre-Bosquet (3), Romain Marlin (3), Flora Donati (4), Yannis Rahou (4), Sylvie van der Werf (4), Etienne Simon-Loriere (4,5), Roger Le Grand (3), Mélanie Prague (2), Jérémie Guedj (1)

2024 - Rome - Italy

Individualized dosing regimen optimization of ustekinumab through a population pharmacokinetic-pharmacodynamic model in patients with psoriasis

Abstract number: 10881

Javier Zarzoso-Foj (1,2), Karine Rodriguez-Fernandez (1,2), Marina Saez-Bello (3), Elena Gras-Colomer (4), Matilde Merino-Sanjuan (1,2), Monica Climente-Marti (1,3), Almudena Mateu-Puchades (5), Victor Mangas-Sanjuan (1,2).

2024 - Rome - Italy

Pharmacometric modeling to capture the time varying pharmacokinetics of PEG-asparaginase in acute lymphoblastic leukemia: A multi-protocol analysis from Nordic and Baltic countries

Abstract number: 11147

Daniel Centanni (1), Mats O. Karlsson (1), Merete Dam (2,3), Anne Mols Krarup (2,3), Birgitte Klug Albertsen (2,3), Lena E. Friberg (1)

2024 - Rome - Italy

Evaluation of automated model development workflows for population pharmacokinetic models

Abstract number: 10857

Elba Raimúndez (1), Rüdiger Siek (1), Andreas Kovar (1), and Ahmed A. Suleiman (1)

2024 - Rome - Italy

Population pharmacokinetic model of encorafenib and binimetinb in real life settings

Abstract number: 11018

Yuan J. Pétermann1* – Abbas Khani1,2* – Alicja Puszkiel3,4 – Benoit Blanchet3,5 – Chantal Csajka1,6,7 - Monia Guidi1,7,8

2024 - Rome - Italy

ODE-free survival modeling with full pharmacokinetic profiles in the IMPRES-M framework

Abstract number: 11205

Lorenzo Cifelli, Csaba Katai, Jeroen Elassaiss-Schaap

2024 - Rome - Italy

Artificial Intelligence and Machine Learning for Next-Generation Model-Informed Precision Medicine: A Tutorial on Practical Applications and Pitfalls

Abstract number: 10759

Nadia Terranova (1) and Uri Nahum (2,3)

2023 - A Coruña - Spain

Development of a novel open-source Physiology-Based Biopharmaceutics Modelling (PBBM) framework using the Open System Pharmacology suite

Abstract number: 11185

Paul Vrenken (1,2), Maria Vertzoni (2), André Dallmann (3)

2024 - Rome - Italy

Transforming the discovery of targeted protein degraders: the translational power of predictive PK/PD modeling

Abstract number: 10762

Robin Thomas Ulrich Haid (1,2), Andreas Reichel (1)

2024 - Rome - Italy

Systemic and ocular physiologically based pharmacokinetic models for protein therapeutics in rabbits

Abstract number: 10831

Ravi Kumar Jairam (1), Maria Franz (2), Anna-Kaisa Rimpelä (3), Guangda Ma (3), Nina Hanke (2), Lars Kuepfer (1)

2024 - Rome - Italy

Pharmacodynamic Drug-Drug Interaction Between Oxaliplatin and HDAC Inhibitors in Colorectal Cancer Cell Lines

Abstract number: 11267

Angelica Squarzoni (1), Mfonabasi Ette (2), Brent Boleslav (2), Elisabetta Donzelli (1), Arianna Scuteri (1), Guido Cavaletti (1), Donald E. Mager (2,3)

2024 - Rome - Italy

Development of a PBPK model to predict monoclonal antibody pharmacokinetics and bioavailability following subcutaneous administration

Abstract number: 10780

Salih Benamara1,3, Donato Teutonico1, Florence Gattacceca3, Laurent Nguyen1, Antoine Deslandes1, Marylore Chenel2, Erik Sjögren2

2024 - Rome - Italy

A translational toolkit to predict clinical Phase IIb/III outcomes from preclinical mouse studies

Abstract number: 10551

Janice JN Goh

2023 - A Coruña - Spain

An Integrated PBPK-Quantitative Systems Pharmacology Model for Statins to Assess the Variability and Implications of Transporter-Mediated Distribution

Abstract number: 10578

Prieto Garcia L. (1,2), Nordell P. (2), Lennernäs H. (1), Ahlström C. (2), Sjögren E. (1)

2023 - A Coruña - Spain

PBPK model-based extrapolation from adults to children to predict furosemide oral solution bioavailability

Abstract number: 10598

Cristian Valiante1, Fatima-zahra Agrad1, Esther Encinas1, Paula Muñiz1, Helen Shaw1, Monica Rodriguez1

2023 - A Coruña - Spain

A first-ever mechanistic disease model of IgG4-related disease identifies high-potential therapy targets

Abstract number: 10708

Milad Ghomlaghi (1), Wanbing Zhao (2), Hui Gao (3), Cuiping Pan (4), Yan Ge (2), Ruimin Sun (2), Di Sun (2), Xiaoqiang Hou (2), Wei Ye (2), Dimitris Christodoulou (1), Shirley Wen (2), Atefeh Kazeroonian (1)

2023 - A Coruña - Spain

Leveraging Open Systems Biology Standards for Improved Reusability and Reproducibility of Pharmacological Models

Abstract number: 10705

Paul Lang (1), Sebastian Miclu?a-Câmpeanu (1), Elisabeth Roesch (1), Chris Rackauckas (1,2,3)

2023 - A Coruña - Spain

R framework for reproducible and quality-controlled modeling and simulation with the Open Systems Pharmacology Software

Abstract number: 10669

Sergei Vavilov (1), Pavel Balazki (1), Stephan Schaller (1), Juri Solodenko (2), Michael Sevestre (3)

2023 - A Coruña - Spain

Studying Targeted Protein Degradation Using a Quantitative Systems Pharmacology (QSP) Approach for Proteolysis Targeting Chimeras (PROTACs)

Abstract number: 10753

Cesar Pichardo-Almarza (1), Nuria Folguera-Blasco (1), Linda Irons (2), Holly Kimko (3)

2023 - A Coruña - Spain

Coupling Quantitative Systems Pharmacology (QSP) and ML/AI: a story of pAIns and gAIns

Abstract number: 11270

Nuria Folguera-Blasco1, Florencia A. T. Boshier1, Aydar Uatay1, Cesar Pichardo-Almarza1, Massimo Lai1, Jacopo Biasetti2, Richard Dearden3, Megan Gibbs4, Holly Kimko5

2024 - Rome - Italy

Population analysis of the in vivo pharmacokinetic characteristics of a letrozole sustained delivery formulation in Beagle dogs

Abstract number: 10837

Adriana Castiñeiras (1,4), Gema López Ginés (4), Iñaki F Trocóniz (1,2,3)

2024 - Rome - Italy

Oral amoxicillin/clavulanate in paediatric patients with severe community acquired pneumonia: a popPK analysis from the PediCAP trial

Abstract number: 11020

Jennie van Dyk (1) on behalf of the PediCAP trial team

2024 - Rome - Italy

A Pharmacokinetic/Pharmacodynamic Model of Recombinant Batroxobin

Abstract number: 10655

Jun Seok Cha(1,2), Do Hoon Keum(3,4), Choon Ok Kim(3), Min Soo Park(3,4,5), Dongwoo Chae(1,3,*)

2023 - A Coruña - Spain

Physiologically based Pharmacokinetic and Pharmacodynamic modeling of Enzalutamide and N-desmethyl enzalutamide

Abstract number: 11165

Jeongmin Ha (1), Hyunjung Lee (2), Seongwon Park (1), Soyoung Lee* (1), Lien Thi Ngo* (1), Hwi-yeol Yun* (1,2), Jung-woo CHAE* (1,2)

2024 - Rome - Italy

Investigating Alternative Daily Dose Regimens for Bedaquiline in Treatment of Multidrug-Resistant Tuberculosis using an Interactive Shiny Application

Abstract number: 10689

Frances Okibedi, Yuanxi Zou and Elin M Svensson

2023 - A Coruña - Spain

Ocular Exposure Extrapolation Across Multiple Species Using PBPK Modeling and Simulation: Latanoprost Solution Case Study

Abstract number: 10458

Maxime Le Merdy, Viera Lukacova

2023 - A Coruña - Spain

Disease-drug-drug interaction in drug repurposing of intravenous imatinib for COVID-19 ARDS

Abstract number: 10511

MM Said (1,2), JR Schippers (3,4), L Atmowihardjo (3,4), Y Li (1), MS van der Plas (1), RAA Mathot (1), HJ Bogaard (3,4), LDJ Bos (3,4) , J Aman (3,4), EL Swart (1,2,5), IH Bartelink (1,2)

2023 - A Coruña - Spain

Pharmacometric analysis of symptom burden during anti-cancer drug therapy by a Markov modelling approach

Abstract number: 11180

Nadja Haas (1), Elli Husso (1), Eduard Schmulenson (1), Mathias Hoiczyk (2), Yon-Dschun Ko (3), Lothar Müller (4), Henning Schulze-Bergkamen (2), Ulrike Schwinger (5), Ulrich Jaehde (1)

2024 - Rome - Italy

Natural disease progression model with transition probabilities to describes the continuum of Alzheimer’s disease

Abstract number: 11162

Noel Patson1,2*, Marwa E.Elhefnawy 2,3*, Samer Mouksassi 4, Goonaseelan (Colin) Pillai 2,5, Emmanuel Chigutsa 6, Ivelina Gueorguieva 7

2024 - Rome - Italy

Translational pharmacology and dose rationale for imatinib and doramapimod as a host-directed therapy for the treatment of pulmonary tuberculosis

Abstract number: 11063

Peter Velickovic (1), Umberto Villani (1), Eik Hoffmann (3), Cyril Gaudin (3), Oscar Della Pasqua (1,2)

2024 - Rome - Italy

Protocol optimization for the evaluation of pharmacokinetics, biomarkers and efficacy of antitubercular drugs in a novel tuberculosis infection model in marmosets

Abstract number: 10684

Silvia Grandoni (1, 2), Peter Velickovic (1, 2), Fatima Rahman (1, 2), Umberto Villani (1, 2), Salvatore D’Agate (1, 2), Candie Joly (5), Julien Lemaitre (5), Laura Via (3,4), Oscar Della Pasqua (1,2)

2023 - A Coruña - Spain

Automatic model discovery in Quantitative Systems Biology

Abstract number: 10706

Sebastian Micluta-Câmpeanu (1), Elisabeth Roesch (1), Paul Lang (1), Chris Rackauckas (1,2,3)

2023 - A Coruña - Spain

Population pharmacokinetic analysis for pediatric patients with inflammatory bowel disease receiving infliximab

Abstract number: 10959

Q. Zhao (1,2), M.M.E Jongsma (3), S.A. Vuijk (3), B.C.M. de Winter (1,2), T.Preijers (1,2), L. de Ridder (3)

2024 - Rome - Italy

Development of a physiological-based pharmacokinetic model for sacubitril and its metabolite

Abstract number: 10426

Tham Thi Bui(1), Khanh Linh Duong(1), Lien Thi Ngo(1), Quyen Thi Tran(1), Hwi-yeol Yun(1,2*), Jung-woo Chae(1,2*) *Those authors contributed equally as correspondence

2023 - A Coruña - Spain

Population pharmacokinetics of intraperitoneal irinotecan and SN-38 in patients with peritoneal metastases from colorectal origin

Abstract number: 10509

P. C. S. Rietveld (1,2), S.D.T. Sassen (1), N.A.D Guchelaar (2), J.W.A. Burger (3), R. H. J. Mathijssen (2), B. C. P. Koch (1), S. L. W. Koolen (1,2)

2023 - A Coruña - Spain

The effect of pH on intratumoural docetaxel release from polymeric nanoparticle CPC634

Abstract number: 11010

Pascale C.S. Rietveld (1,2), Stijn L.W. Koolen (1,2), Stefan Zeiser (3), Nelleke Snelder (3), Cristianne J. Rijcken (4), Birgit C.P. Koch (1), Ron H.J. Mathijssen (2), Sebastiaan D.T. Sassen (1)

2024 - Rome - Italy

The Applied Pharmacometrics Training Program – Year 3 Sustainability

Abstract number: 11137

Innocent Gerald Asiimwe1,2, Samer Mouksassi3, Rik de Greef4, Eric Decloedt5, Paolo Denti2,6, Phumla Sinxadi2,6, Catriona Waitt1,2,7, Goonaseelan (Colin) Pillai2,6,8

2024 - Rome - Italy

Pharmacometric modelling to describe pharmacokinetics and exposure-response of ivermectin in adolescent patients infected with Trichuris trichiura

Abstract number: 11002

David Ajayi (1,2), Ochuko M. Orherhe (1,3), Goonaseelan (Colin) Pillai (1,4,5), Samer Mouksassi (1,6), Britta Steffens (7), Dominic Bräm (7), Viviane Sprecher (8,9), Daniela Hoffmann (8,9), Michael Buettcher (7,9,10), Jean T. Coulibaly (11,12), Said M. Ali (13), Jennifer Keiser (8,9), Marc Pfister (7,11)

2024 - Rome - Italy

Enlightenment the strategic selection of pegylated rHuEPO candidates using a mechanistic model- driven extrapolation approach of the pharmacokinetics and pharmacodynamics.

Abstract number: 10641

Gledys Reynaldo Fernandez (1), Leyanis Rodriguez-Vera (1), Jorge Duconge (2), Daniel Amaro (3), Joaquin Solozábal (3), Victor Mangas-Sanjuan (4,5) Iñaki Troconiz (6), and Valvanera Vozmediano (1)

2023 - A Coruña - Spain

Incorporating complex drug PK with multiple binding targets into a QSP model to predict combined PD effects

Abstract number: 10552

Rebecca Baillie (4), Jared Cui (4), Krishnakant Dasika (4), Hans-Christoph Schneider (1), Panteleimon Mavroudis (2), Laura Sargentini (3), Britta Wagenhuber (1), Katherine Kudrycki (4), Mike Reed (4)

2023 - A Coruña - Spain

Optimizing IMC-001 Dosage Regimens Using Target Mediated Drug Disposition Model: Enhancing Therapeutic Efficacy and Safety in Cancer Treatment

Abstract number: 10927

Taewook Sung1, Jihyun Jeon1, Sung Young Lee2, SuYeon Kim2, Seongyeon Kang2, Sung Ho Kim2, Heung Tae Kim2, Soyoung Lee1*, Jung-woo Chae1,3*, Hwi-yeol Yun1,3*

2024 - Rome - Italy

MaS: population pharmacometric modeling in Python

Abstract number: 10676

Chongyi Xu (1), Jiesen Yu (1), Wenjie Cao (1), Haikuo Lu (1), Ze Yao (1), Xin Sun (1), Kaifan Zhang (1), Jieren Luo (2), Qingshan Zheng (2), Han Zheng (1)

2023 - A Coruña - Spain

Quantifying the impact of infection on murine antibiotic exposure in the framework of non-conventional treatment modalities within the FAIR study

Abstract number: 10809

Miriam S.R. Happ (1,2), Linda B.S. Aulin (1), Mélanie Mondemé (3), Mara Baldry (3), Wilhelm Huisinga (4), Christelle Faveeuw (3), Jean-Claude Sirard (3), Charlotte Kloft (1) and Robin Michelet (1)

2024 - Rome - Italy

Enalapril orodispersible minitablets for pediatric heart failure – a population pharmacokinetic analysis from multicenter Phase II/III LENA clinical trials

Abstract number: 10341

Muhammad Faisal (1), Melina Steichert (1), Willi Cawello (1), Stephanie Laeer (1) and the LENA consortium

2023 - A Coruña - Spain

Pharmacokinetic model-informed precision dosing of natalizumab in Multiple Sclerosis

Abstract number: 10891

Stefan P. H. van den Berg (1), Alyssa A. Toorop (3), Femke Hooijberg (4), Gertjan Wolbink (4), Nivea M.F. Voelkner (1), Liza M.Y. Gelissen (3), Joep Killestein (3), Zoé L. E. van Kempen (3), Thomas P.C. Dorlo (2), Theo Rispens (1)

2024 - Rome - Italy

Do critically ill patients undergoing continuous renal replacement therapy require ceftaroline dosage adjustments? Ceftaroline PopPK model and dosage simulations with probability of target attainment analysis based on retrospective data.

Abstract number: 11166

Arkadiusz Adamiszak (1,2), Agnieszka Bienert (1)

2024 - Rome - Italy