abstracts-archive - PAGE Meeting (Population Approach Group Europe)

Abstracts found: 6935

A population pharmacokinetic model for sertraline in depressive patients during the perinatal period: prediction of infant drug exposure through placenta and human milk

Abstract number: 10414

Poster: Drug/Disease Modelling - Safety

Anaëlle Monfort (1), Evelina Cardoso (2), Chin B. Eap (3-6), Céline J. Fischer Fumeaux (7), Myriam Bickle Graz (7), Mathilde Morisod Harari (8), Étienne Weisskopf (3), Jean-Michel Hascöet (9), Olivier Claris (10,11), Manuella Epiney (12), Grégoire Leclair (1), Ema Ferreira (1), Chantal Csajka (3-5), Alice Panchaud (2,13), Monia Guidi (2,14)

2023 - A Coruña - Spain

A pharmacokinetic-pharmacodynamic model characterizing antibiotic-induced morphological changes in Pseudomonas aeruginosa from time-lapse microscopy images

Abstract number: 10206

Poster: Drug/Disease Modelling - Infection

Eva Sörensson (1), Chenyan Zhao (1), Pikkei Wistrand-Yuen (2), Pernilla Lagerbäck (2), Thomas Tängden (2), Elisabet I Nielsen (1)

2022 - Ljubljana - Slovenia

Amikacin dose optimization in the emergency department: A population pharmaco-kinetic simulation study

Abstract number: 10042

Poster: Clinical Applications

Nada Dia (1), Sabrina De Winter (2), Omar Elkayal (1), Beatrijs Mertens (1), Peter Vanbrabant (3), Willy Peetermans (3), Isabel Spriet (1,2), and Erwin Dreesen (1)

2022 - Ljubljana - Slovenia

Model-informed comparison of the clinical relevance of four renal function markers on meropenem target attainment in critically ill septic patients

Abstract number: 10943

Poster: Drug/Disease Modelling - Other Topics

Nada Dia (1), Zakaria Blaine (1,2), Matthias Gijsen (1,3), Joost Wauters (4,5), Isabel Spriet (1,3), Erwin Dreesen (1)

2024 - Rome - Italy

Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to medicines: a contribution from the ConcePTION Project

Abstract number: 10478

Poster: Drug/Disease Modelling - Other Topics

Nina Nauwelaerts (1) , Julia Macente (1) , Neel Deferm (1,2) , Rodolfo Hernandes Bonan (3) , Miao-Chan Huang (1) , Martje Van Neste (4), David Bibi (5), Justine Badee (6), Frederico S. Martins (1), Anne Smits (7, 8, 9) Karel Allegaert (4, 7, 8, 10), Thomas Bouillon (3), Pieter Annaert (1, 3)

2023 - A Coruña - Spain

Physiologically-Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to Sildenafil and Bosentan: a contribution from the ConcePTION Project

Abstract number: 10148

Poster: Drug/Disease Modelling - Absorption & PBPK

Nina Nauwelaerts (1), Neel Deferm (1), Julia Macente (1), Bart Lammens (2), Karel Allegaert (1), Thomas Bouillon (2, 3), Anne Smits (1), Pieter Annaert (1,2)

2022 - Ljubljana - Slovenia

The comparison of pharmacoeconomic and pharmacometric modelling to improve cost-effectiveness assessment of sunitinib in GIST.

Abstract number: 10166

Poster: Drug/Disease Modelling - Oncology

J. Nijhuis, M. Centanni

2022 - Ljubljana - Slovenia

A Population Pharmacokinetic Model for Creatinine with and without ingestion of cooked meat

Abstract number: 10081

Poster: Clinical Applications

Zhendong Chen (1), Chunli Chen (1), Max Taubert (1), Michael Mayersohn (2), Uwe Fuhr (1)

2022 - Ljubljana - Slovenia

Plasma and cerebrospinal fluid population pharmacokinetics of vancomycin in patients with external ventricular drain

Abstract number: 10318

Poster: Drug/Disease Modelling - Infection

Zhendong Chen (1), Max Taubert (1), Chunli Chen (1,2), Charalambos Dokos (1), Uwe Fuhr (1), Thomas Weig (3), Michael Zoller (3), Suzette Heck (4), Konstantinos Dimitriadis (4,5), Nicole Terpolilli (5,6), Christina Kinast (3), Christina Scharf (3), Constantin Lier (7), Christoph Dorn (7), Uwe Liebchen (3)

2023 - A Coruña - Spain

Physiologically Based Pharmacokinetic Modeling of a CYP3A4-Mediated Drug-Drug Interaction: Prediction of Victim of Induction, not Inhibition, with a Moderate Fraction Metabolized by CYP3A4

Abstract number: 10061

Poster: Drug/Disease Modelling - Absorption & PBPK

Fiona Plait, Elise Dunzo, Noha Rayad, Laura Iavarone

2022 - Ljubljana - Slovenia

Comparing full Bayesian estimation to maximum a posteriori (MAP) Bayesian estimation in three routine clinical care scenarios

Abstract number: 10233

Poster: Methodology - Estimation Methods

Dominic MH Tong (1), Jasmine H Hughes (1), Ron J Keizer (1)

2022 - Ljubljana - Slovenia

Finch Studio: A Next Generation NONMEM Modeling Workbench

Abstract number: 10062

Poster: Software Demonstration

Mohamed Ismail (1), Scott Van Wart (1), Donald E. Mager (1, 2)

2022 - Ljubljana - Slovenia

Using preclinical data to predict human pharmacokinetics of monoclonal antibodies for first-in-human dose setting: A review of five internal case studies

Abstract number: 10030

Poster: Methodology - Other topics

Rodrigues C (1), Hansen L (2), Skartved NJ (2), Tessier A (1)

2022 - Ljubljana - Slovenia

Optimizing the Dose Escalation of a new anti-CD73 monoclonal antibody for target Inhibition: A Comprehensive Preclinical and Clinical Modelling Approach

Abstract number: 10910

Poster: Drug/Disease Modelling - Oncology

Christelle Rodrigues [1], Najah Harouki [1], Julie Legrand [1], Niels J Skartved [2], Janus S Jakobsen [2], Camilla Frölich [2], Rikke Hald [2], Maria Almena-Carrasco [1], Fanny Cazade [1], Adrien Tessier [1]

2024 - Rome - Italy

An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies

Abstract number: 11153

Poster: Methodology - Other topics

Csaba Katai (1), Shepard J. Smithline (2), Jeroen Elassaiss-Schaap (1), Craig J. Thalhauser (2), Sieto Bosgra (3)

2024 - Rome - Italy

An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies

Abstract number: 10391

Poster: Methodology - Other topics

Csaba Katai (1), Jeroen Elassaiss-Schaap (1), Shepard J. Smithline (2), Craig J. Thalhauser (2), Sieto Bosgra (2)

2023 - A Coruña - Spain

Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat

Abstract number: 10580

Poster: Oral: Lewis Sheiner Student Session

Alessandro De Carlo (1), Elena Maria Tosca (1), Paolo Magni (1)

2023 - A Coruña - Spain

A Two-Stages Global Sensitivity Analysis in presence of correlated inputs: Application on a Tumor-in-host-growth Inhibition model based on the Dynamic Energy Budget theory

Abstract number: 10055

Poster: Methodology - New Modelling Approaches

Alessandro De Carlo (1), Elena Maria Tosca (1), Nicola Melillo (1,2), Paolo Magni (1)

2022 - Ljubljana - Slovenia

PopPK-PD modelling of Carboplatin-induced myelosuppression to support therapeutic drug monitoring and dose individualization in cancer patients using Electronic Health Record Data

Abstract number: 10981

Poster: Real-world data (RWD) in pharmacometrics

Alessandro De Carlo (1), Mirjam Crul(2,3), Tim Schutte (2), Lia van Zuylen (2,3), Idris Bahce (2), Chi Fong Loo (2), Daan van Valkengoed (2,4), Harmen Huls (2), Elena Maria Tosca (1), Paolo Magni (1)*, Imke Bartelink* (2,3)

2024 - Rome - Italy

Population pharmacokinetic-pharmacodynamic model of subcutaneous bupivacaine in a novel extended-release microparticle formulation

Abstract number: 10766

Poster: Drug/Disease Modelling - Other Topics

Ida Klitzing Storgaard (1), Elisabeth Kjær Jensen (2,3), Mads Utke Werner (2,3,4), and Trine Meldgaard Lund (1)

2024 - Rome - Italy

A mechanistic model of thymocyte dynamics: a quantitative tool for predicting drug effects on thymic function

Abstract number: 11148

Poster: Drug/Disease Modelling - Other Topics

Victoria Kulesh (1,2,3), Kirill Peskov (1,2,3), Gabriel Helmlinger (4), Gennady Bocharov (3,5,6)

2024 - Rome - Italy

Impact of sampling procedure on individual pharmacokinetic parameter estimation methods

Abstract number: 11006

Poster: Methodology - Estimation Methods

Marina Cuquerella-Gilabert (1,2,3,4), Sergio Sánchez Herrero (3), Matilde Merino Sanjuan (1,2), Elena Tosca (4), Victor Mangas Sanjuan (1,2), Paolo Magni (4)

2024 - Rome - Italy

Towards PBPK model development for oral absorption in PhysPK

Abstract number: 10048

Poster: Methodology - New Modelling Approaches

Marina Cuquerella-Gilabert(1), Jenifer Serna (2), Almudena Rueda-Ferreiro(2), Matilde Merino-Sanjuan (1,3), Sergio Sánchez-Herrero (2), Victor Mangas-Sanjuan (1,3)

2022 - Ljubljana - Slovenia

Title: Development of a Compartmental Advanced Physiologically based Dissolution, Absorption and Transit (CA-PhysDAT) model in PhysPK

Abstract number: 10463

Poster: Drug/Disease Modelling - Absorption & PBPK

Marina Cuquerella-Gilabert(1,3), Javier Reig-López(1,3), Jenifer Serna (2), Almudena Rueda-Ferreiro(2), Matilde Merino-Sanjuan (1,3), Sergio Sánchez-Herrero (2), Victor Mangas-Sanjuan (1,3)

2023 - A Coruña - Spain

Neural ODE structures based on pharmacokinetic principles

Abstract number: 10620

Poster: Oral: Other Topics

Dominic Stefan Bräm (1), Uri Nahum (1), Marc Pfister (1), Johannes Schropp (2), and Gilbert Koch (1)

2023 - A Coruña - Spain

Opportunities of Covariate Data Imputation with Machine Learning for Pharmacometricians in R

Abstract number: 9982

Poster: Methodology – AI/Machine Learning

Dominic Stefan Bräm (1), Uri Nahum (1), Andrew Atkinson (1), Gilbert Koch (1), and Marc Pfister (1)

2022 - Ljubljana - Slovenia

Multivariate Exact Discrepancy : a new tool for PK/PD model evaluation

Abstract number: 10568

Poster: Oral: Methodology - New Tools

Sarah Baklouti (1,2), Emmanuelle Comets (3,4), Peggy Gandia (1,2), Didier Concordet (2)

2023 - A Coruña - Spain

A methodology to de-shrink Empirical Bayes Estimates

Abstract number: 10236

Poster: Oral: Methodology - New Modelling Approaches

Sarah Baklouti (1,2), Peggy Gandia (1,2), Didier Concordet (2)

2022 - Ljubljana - Slovenia

Value of literature review to inform development and use of biologics in juvenile idiopathic arthritis

Abstract number: 10109

Poster: Drug/Disease Modelling - Paediatrics

Klervi Golhen (1)(*), Carolyn Winskill (2)(*), Cynthia Yeh (2), Nancy Zhang (2), Tatjana Welzel (1)(3)(*) & Marc Pfister (1)(2)(*)

2022 - Ljubljana - Slovenia

Characterizing effect of methotrexate on adalimumab PK in pediatric patients with inflammatory rheumatic disease

Abstract number: 10693

Poster: Drug/Disease Modelling - Paediatrics

Klervi Golhen1*, Tatjana Welzel1,2,3*, Andrew Atkinson1, Verena Gotta1, Jasmin Kuemmerle-Deschner2, Gilbert Koch1, Johannes van den Anker1, Andreas Woerner2*, Marc Pfister1*

2023 - A Coruña - Spain

Empirical Power Evaluations of an Item Response Model in Parkinson’s Disease Patients

Abstract number: 10416

Poster: Methodology - Study Design

Ana Novakovic1, Kris Jamsen1, Camille Vong2, Usman Arshad2, Chao Chen2

2023 - A Coruña - Spain

Model-based analysis of patient-derived organoids for evaluating anticancer drugs

Abstract number: 10452

Poster: Drug/Disease Modelling - Oncology

Davide Ronchi1, Elena Maria Tosca1, Silvia De Siervi2, Cristian Turato2, Marco Gaetano Lolicato2, Paolo Magni1

2023 - A Coruña - Spain

Facing the limits of the genetic algorithms for covariate selection

Abstract number: 10098

Poster: Methodology – AI/Machine Learning

Davide Ronchi(1), Elena Maria Tosca(1), Isaia Ravasi(1), Roberta Bartolucci(1), Paolo Magni(1)

2022 - Ljubljana - Slovenia

Translational modeling of tumor response to treatment: bridging preclinical to clinical studies

Abstract number: 11049

Poster: Drug/Disease Modelling - Oncology

Davide Ronchi1, Elena Maria Tosca1, Emmanuelle Comets2,3, Julie Bertrand2, Paolo Magni1

2024 - Rome - Italy

Model-based assessment of early bactericidal activity of rifampicin in combination with meropenem plus amoxicillin/clavulanate among adults with rifampicin-resistant pulmonary tuberculosis

Abstract number: 11061

Poster: Drug/Disease Modelling - Infection

Veronique de Jager (1), Laurynas Mockeliunas (2), Huifang You (2), Ulrika SH Simonsson (2), Tarryn Collings (1), Caryn Upton (1), Will Oosthuysen (1), Nikhil Gupte (3,4), Susan Dorman (5), Eric Nuermberger (3), Andreas Diacon (1), Kelly E. Dooley (6) and the COMRADE Study Team

2024 - Rome - Italy

Numerical validation of Tucuxi, a promising new Bayesian adaptation tool

Abstract number: 10806

Poster: Methodology - Other topics

Anne Ravix (1), Annie E. Cathignol (2,3), Chantal Csajka (1,4,5), Yann Thoma (3,*), Monia Guidi (1,4,6,*)

2024 - Rome - Italy

Dosing optimization of amoxicillin in children treated for Lyme disease

Abstract number: 10335

Poster: Drug/Disease Modelling - Paediatrics

Anne Ravix (1), Verena Gotta (2,3), Paolo Paioni (3,4), Marc Pfister (2,3), Monia Guidi (1,5,6,*), Chantal Csajka (1,3,6,7,*)

2023 - A Coruña - Spain

Population pharmacokinetic study of lacosamide in children and adults with epilepsy

Abstract number: 10027

Poster: Drug/Disease Modelling - CNS

Anne Ravix (1), Pascal André (2), Jan Novy (3), Chantal Csajka (1,4,5,*), Monia Guidi (1,2,*)

2022 - Ljubljana - Slovenia

Joint modeling of longitudinal and time-to-event data for earlier estimation of the primary endpoint in oncology clinical trials: A retrospective analysis of the ICARIA-MM clinical trial

Abstract number: 9993

Poster: Drug/Disease Modelling - Oncology

Antoine Pitoy (1,2,3), Solène Desmée (2), Marc Cerou (3), Hoai-Thu Thai (3), Christine Veyrat-Follet (3), Julie Bertrand (1)

2022 - Ljubljana - Slovenia

Contribution of modelling jointly progression-free survival and biomarker longitudinal data for therapeutic evaluation in oncology

Abstract number: 10374

Poster: Drug/Disease Modelling - Oncology

Antoine Pitoy (1,2,3), Solène Desmée (2), Hoai-Thu Thai (1), Marc Cerou (1), Dorothee Semiond (4), Christine Veyrat-Follet (1), Julie Bertrand (3)

2023 - A Coruña - Spain

Estimation of phase III trial outcome in oncology using joint models of longitudinal biomarker and time-to-event data

Abstract number: 11152

Poster: Drug/Disease Modelling - Oncology

Antoine Pitoy

2024 - Rome - Italy

Innovative Machine Learning Based Algorithm to Differentiate Between Diabetes Insipidus and Primary Polydipsia in Clinical Practice

Abstract number: 10117

Poster: Methodology – AI/Machine Learning

Uri Nahum (1), Julie Refardt (2), Irina Chifu (3), Wiebke Kristin Fenske (4,5), Martin Fassnacht (3,6), Gabor Szinnai (1), Mirjam Christ-Crain (2) and Marc Pfister (1)

2022 - Ljubljana - Slovenia

Mathematical Modeling Of Gut Microbiota Diversity Under The Effects of Beta-lactam Antibiotics

Abstract number: 11065

Poster: Oral: Drug/Disease Modelling - Other Topics

Carlos Olivares (1), Jean de Gunzburg (2), Etienne Ruppe (1), Tanguy Corbel (2), Stéphanie Ferreira (2), Jeremie Guedj (1), Charles Burdet (1)

2024 - Rome - Italy

Implementation of neural ordinary differential equations in the pharmacometric software packages Monolix, NONMEM, and nlmixr

Abstract number: 10870

Poster: Methodology – AI/Machine Learning

Dominic Stefan Braem (1), Bernhard Steiert (2), Britta Steffens (1), Marc Pfister (1), and Gilbert Koch (1)

2024 - Rome - Italy

Item Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias

Abstract number: 10626

Poster: Oral: Drug/Disease Modelling - Other Topics

Alzahra Hamdan (1), Andrew C. Hooker (1), Xiaomei Chen (1), Andreas Traschütz (2,3), Rebecca Schüle (2,4), Matthis Synofzik (2,3), Mats O. Karlsson (1)

2023 - A Coruña - Spain

Integrated modeling of digital-motor outcomes and clinical outcome assessments using IRT: a framework for developing better outcomes for clinical trials in rare neurological diseases

Abstract number: 11161

Poster: Oral: Drug/Disease Modelling - Other Topics

Alzahra Hamdan (1), Andreas Traschütz (2,3), Lukas Beichert (2,3), Xiaomei Chen (1), Rebecca Schüle (2,4), Andrew C. Hooker (1), PROSPAX consortium, Matthis Synofzik (2,3), Mats O. Karlsson (1)

2024 - Rome - Italy

Feedforward neural network as a surrogate for the reinforcement learning action-value function in a model-informed precision dosing oncology application

Abstract number: 10219

Poster: Methodology – AI/Machine Learning

Katherine Briceño-Guerrero (1), Manfred Opper (2), Niklas Hartung (1), Wilhelm Huisinga (1), Jana de Wiljes (1)

2022 - Ljubljana - Slovenia

Population pharmacokinetics of the antitubercular drug TBAJ587 and its two main metabolites

Abstract number: 10347

Poster: Drug/Disease Modelling - Infection

Albin Leding (1), Paul Bruinenberg (2), Almari Conradie (2), Jerry Nedelman (2), Ulrika S.H. Simonsson (1)

2023 - A Coruña - Spain

Semi-mechanistic model of the Haemodynamic effects of propofol and remifentanil administered in combination to patients undergoing general anaesthesia

Abstract number: 10613

Poster: Drug/Disease Modelling - Other Topics

Maite Garraza-Obaldia (1,2), Zinnia P Parra-Guillén(1,2), Joan Altés (3), Sebastián Jaramillo (4), José Fernando Valencia (5), Pedro L Gambús (4), Iñaki F Troconiz (1,2,6)

2023 - A Coruña - Spain

Semi-mechanistic model of pulmonary ventilation changes during propofol and remifentanil infusion as measured by minute-volume and transcutaneous pCO2.

Abstract number: 10880

Poster: Drug/Disease Modelling - Other Topics

Maite Garraza-Obaldia (1,2), Sebastián Jaramillo (3), Zinnia P Parra-Guillén(1,2), José Fernando Valencia (4), Pedro L Gambús (3), Iñaki F Troconiz (1,2,5)

2024 - Rome - Italy