Thursday 16 October, 2025
Background: Overactive bladder (OAB) is a condition that refers to the appearance of unwanted and uncontrolled contractions in the bladder…
Read moreAbstracts
Assessing insulin sensitivity, glucose effectiveness, and β-cell responsivity using an integrated glucose, insulin, and C-peptide minimal model
Thursday 16 October, 2025
Objectives: Intravenous glucose tolerance tests (IVGTT) have been widely used to investigate the glucose-insulin interaction in subjects with and without…
Read moreAssessing Glucagon Kinetics through Nonlinear Mixed Effects Modeling
Thursday 16 October, 2025
Objectives:A concomitance of both defective insulin secretion and impaired glucagon suppression leads to the development of impaired glucose tolerance in…
Read moreUse of the Minimally-Invasive Oral Minimal Model to Quantify the Effect of Fat and Protein on the Postprandial Glucose Excursion in Individuals with Type 1 Diabetes under Free-living Conditions
Thursday 16 October, 2025
Objectives: Individuals with type 1 diabetes (T1D) have to constantly monitor and control their blood glucose (BG) levels through the…
Read morePhysiologically based pharmacokinetic (PBPK) modelling of drug-drug interactions between long-acting cabotegravir and rilpivirine with oral rifabutin
Thursday 16 October, 2025
Introduction: Tuberculosis remains the primary cause of death among people living with HIV [1]. First-line treatment for tuberculosis often includes…
Read moreNintedanib physiologically based pharmacokinetic (PBPK) model to predict drug-drug interactions
Thursday 16 October, 2025
Background and objectives: Nintedanib is a narrow therapy index drug and an essential co-medication to treat idiopathic pulmonary fibrosis (IPF). It…
Read morePreeclampsia increases maternal exposure to betamethasone in pregnancy: a population pharmacokinetic study
Thursday 16 October, 2025
Objectives: Maternal dosing of antenatal corticosteroids (ACS) to improve fetal lung development in case of imminent preterm birth has remained the…
Read morePopulation pharmacokinetics of dexamethasone in critically ill COVID-19 patients: does inflammation play a role?
Thursday 16 October, 2025
Objectives: One of the common causes of COVID-19 related death is acute respiratory distress syndrome (C-ARDS). Dexamethasone is the cornerstone…
Read moreModel informed precision dosing of meropenem in critically ill patients: mission impossible?
Thursday 16 October, 2025
Objectives: Meropenem is a beta-lactam antibiotic that is frequently used to treat serious infections in critically ill patients. Previous population…
Read moreOral versus intravenous amoxicillin in neonates: a population pharmacokinetic study
Thursday 16 October, 2025
Introduction/Objectives: In neonates, use of oral antibiotics is limited due to lacking evidence on pharmacokinetics (PK) and adequate exposure after…
Read more