Thursday 16 October, 2025
Objectives: In patients with recurrent advanced ovarian cancer (AOC), the development of combined immunotherapy + anti-angiogenic + PARP inhibitor agents…
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Prognostic value of the modeled CA-125 kinetics parameter KELIM-PARP in patients with advanced ovarian cancer (AOC): analysis of the phase II BOLD study
Thursday 16 October, 2025
Objectives: In patients with recurrent High Grade Ovarian Cancer (HGOC), the combination of durvalumab (anti-PL1 monoclonal antibody), olaparib (PARP inhibitor)…
Read morePopulation pharmacokinetics of amoxicillin in postpartum minipig plasma
Thursday 16 October, 2025
Objectives: Antibiotics are frequently prescribed to postpartum women and nursing mothers for prophylaxis and treatment of infections. In the latter…
Read morePopulation pharmacokinetic analysis of amoxicillin in postpartum Göttingen Minipig plasma and milk: a contribution from the ConcePTION project
Thursday 16 October, 2025
Objectives: The knowledge gap of whether a drug would transfer into milk has existed for most medicines since their drug…
Read moreSpatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease
Thursday 16 October, 2025
Objectives: Tuberculosis (TB) is an infectious disease that can lead to lung cavitation and death. In the hardest-to-treat population, those…
Read moreA translational site-of-action PK-PD modeling platform to propose treatment shortening regimens for tuberculosis
Thursday 16 October, 2025
Objectives: To treat tuberculosis (TB), drugs must travel from the central circulation to bacterial lesions [1]. It is thus important…
Read morePopulation pharmacokinetics of fluconazole in critically ill patients: an individual patient data meta-analysis.
Thursday 16 October, 2025
Introduction: Fluconazole is a triazole antifungal commonly used to prevent and treat invasive candidiasis [1]. It is largely eliminated through renal…
Read moreMultiple imputation to handle missing covariate data in pharmacometrics modelling
Thursday 16 October, 2025
Introduction: Missingness of covariate data is a prevalent challenge in pharmacometrics research [1]. Covariate data may be incomplete under three mechanisms:…
Read moreA mechanistic model of pure and lipid-mediated alpha-synuclein aggregation to advance therapeutic strategies against Parkinson’s disease
Thursday 16 October, 2025
Objectives: The neuronal protein alpha-synuclein (aSyn) holds a crucial role in the intricate molecular landscape of Parkinson’s disease. While aSyn…
Read moreA mechanistic model of α-synuclein aggregation and degradation to bridge in vitro and in vivo research on Parkinson’s disease.
Thursday 16 October, 2025
Objectives: Parkinson’s disease is a debilitating neurodegenerative disorder characterized by an intricate network of molecular mechanisms [1]. Such a biological…
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