Thursday 16 October, 2025
Objectives: ERAMET (Ecosystem for RApid adoption of modelling and simulation METhods) is a recently funded (HORIZON-HLTH-2023-IND-06-04) initiative to address regulatory…
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Modeling of the Pharmacokinetics of the Selective Orexin-1 Receptor Antagonist ACT-539313 with Auto-Inhibition
Thursday 16 October, 2025
Objectives: Binge eating disorder is a condition characterized by recurrent episodes of excessive food intake, accompanied by a sense of…
Read moreModeling biology by agents
Thursday 16 October, 2025
Objectives: We describe the agent-based modelling methodology for simulating complex biological phenomena. Overview/Description of presentation: The agent-based modelling (ABM) paradigm is…
Read morePerformance evaluation of the full Automatic Model Development (AMD) tool when the true model is known
Thursday 16 October, 2025
Introduction: The Automatic Model Development (AMD) tool in Pharmpy is an open source tool for automatic population pharmacokinetic (PK) model…
Read moreApplication of physiologically-based kinetic (PBK) modeling in revealing the role of the bile-salt efflux pump (BSEP) in bosentan-induced cholestasis
Thursday 16 October, 2025
Objectives: In Western countries, drug-induced liver injury (DILI) has been the major source of acute liver failure [1,2]. When DILI…
Read morestormTB: SimulaTOR of a murine Minimal-pbpk model for anti-TB drugs
Thursday 16 October, 2025
Introduction/Objectives: In 2022 Tuberculosis (TB) was the second cause of death due to a single infectious agent after COVID-19 and…
Read moreAutomatized reporting in the applications of MonolixSuite
Thursday 16 October, 2025
Objectives: Monolix, a tool for parameter estimation in non-linear mixed effects models and model diagnosis, provides an efficient way to…
Read moreDevelopment of a level A in vitro/in vivo correlation (IVIVC) using applications of the MonolixSuite
Thursday 16 October, 2025
Objectives: Post-approval changes in manufacturing processes or approvals of new strengths of a drug product require expensive and often long…
Read moreIdentification and quantification of variability in the microdialysis technique using mixed-effects modelling within an integrated in vitro and ex vivo approach: a linezolid case study.
Thursday 16 October, 2025
Objectives: In the treatment of infections, the unbound drug concentration at the target site, i.e. the interstitial space fluid (ISF), is…
Read moreUnderstanding variability in microdialysis measurements: introducing a combined calibration approach for piperacillin and tazobactam in LPS-induced septic piglets
Thursday 16 October, 2025
Objectives: Case fatality rates of septic children are reported at 20% [1]. Inadequate target tissue exposure is hypothesised to lead…
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