Thursday 16 October, 2025
Introduction: Paediatric physiologically based pharmacokinetic models have been applied for various aims such as dose selection, new formulation development, and…
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Development of User-Friendly Bayesian Predictive Platform for Blood Boron-10 Pharmacokinetics following Intravenous Infusion of [10B] L-4-BORONOPHENYLALANINE
Thursday 16 October, 2025
Introduction: Boron neutron capture therapy (BNCT) allows high-precision radiotherapy against tumor using boron-10 (10B) with tumor-localizing characteristics and has a…
Read moreDisease progression modeling analysis of the change of bone mineral density by postoperative hormone therapies in postmenopausal patients with early breast cancer
Thursday 16 October, 2025
Introduction: The adverse effects of AI except on the musculoskeletal system are less than tamoxifen in breast cancer patients, but…
Read moreCase study of Exposure-Safety analysis in Phase 1 oncology – lessons learned
Thursday 16 October, 2025
Objectives: Exposure-safety (E-S) analyses in Phase 1 oncology studies can support future study design elements, particularly selection of dosing regimens….
Read moremastering upset plots: a comprehensive tutorial for effective data visualization in pharmacometrics and drug development
Thursday 16 October, 2025
Introduction/Objectives: In the realm of data analysis, the examination of variable intersections holds paramount importance as it often unveils crucial…
Read moreapmx: an open-source R package for automated PK and PKPD dataset assembly
Thursday 16 October, 2025
Introduction: Several NONMEM [1] tools have been developed in recent years in R to support PK and PKPD analyses [2],…
Read moreComparison of monoclonal antibody disposition predictions between different PBPK platforms
Thursday 16 October, 2025
Objectives: Most monoclonal antibodies (mAbs) target soluble- or membrane bound antigens located outside the vasculature [1]. While these concentrations at the…
Read moreMechanistic model of antibody response, SARS-CoV-2 viral loads and genetic mutation burden to optimise molnupiravir dosing
Thursday 16 October, 2025
Introduction: Mathematical models play a crucial role in providing better insights on SARS-CoV-2 dynamics, allowing the prediction of clinical efficacy…
Read morePopulation pharmacokinetic modelling of dolutegravir, tenofovir and emtricitabine in non-human primates
Thursday 16 October, 2025
Objectives: Current antiretroviral treatment (ART) is effective in achieving and maintaining undetectable plasma HIV-RNA levels but it does not eradicate…
Read moreFirst-in-Human Dose Selection for TU7710 through Pharmacokinetic and Pharmacodynamic Modeling and Simulation
Thursday 16 October, 2025
Objectives: TU7710 is a recombinant human coagulation factor VIIa, in which human transferrin is linked in order to increase half-life. Factor…
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