Thursday 16 October, 2025
Introduction: Budesonide is a corticosteroid drug commonly used to treat asthma and rhinitis [2], but also it appears to be…
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Oral absorption modeling of weakly basic drugs – Combining in vitro and in silico models
Thursday 16 October, 2025
Introduction: During formulation development of weakly basic drug candidates, special attention should be paid to potential drug precipitation during gastrointestinal…
Read moreDevelopment of mPBPK model to support translation decision-making for novel bispecific therapeutics
Thursday 16 October, 2025
BackgroundBispecific therapeutics have emerged as a promising class due to their ability to target two distinct antigens simultaneously, resulting in…
Read moreParacetamol (Acetaminophen) and Metabolites Population Pharmacokinetics Model in children and adults with Spinal Muscular Atrophy
Thursday 16 October, 2025
Introduction: Spinal muscular atrophy (SMA) is neuromuscular disorder characterized by progressive muscular weakness and low skeletal muscle mass. Paracetamol is…
Read morePharmacokinetic analysis of pyrazinamide in a South African population with tuberculosis meningitis and HIV
Thursday 16 October, 2025
Objectives: Tuberculosis meningitis (TBM) is a devastating manifestation of infection by Mycobacterium tuberculosis and is associated with severe morbidity and…
Read moreLong-acting formulation drug-drug interactions: evaluating the importance of timing using a subcutaneous levonorgestrel PBPK example
Thursday 16 October, 2025
Introduction: Long-acting drug formulations, such as injectables or subcutaneous implants, can provide significant benefits for drugs being taken for long…
Read morePemba Island, Tanzania, versus Côte d’Ivoire – Population effect on apparent clearance of active albendazole metabolites
Thursday 16 October, 2025
Objectives: Soil transmitted helminth infections affect an estimated 24% of the world’s population [1]. Communities with poor access to sanitation…
Read moreExposure-Response Analysis Using Time to Event Data for Bevacizumab Biosimilar, SB8 and the Reference Bevacizumab
Thursday 16 October, 2025
Introduction: SB8 is a biosimilar of the reference Avastin® (bevacizumab), a humanized anti-VEGF monoclonal antibody for treatment of solid tumors….
Read moreWeight-band based simplification of oral allometric miltefosine dosing in pediatric patients with visceral leishmaniasis in Eastern Africa
Thursday 16 October, 2025
Introduction: Achieving adequate levels of miltefosine exposure in pediatric patients in the neglected tropical disease leishmaniasis has been challenging. Conventional…
Read morePopulation pharmacokinetic analysis of guanabenz in children with Vanishing White Matter: Evaluating scaling adult drug safety and pharmacokinetics data
Thursday 16 October, 2025
Introduction: Vanishing White Matter (VWM) is an inherited leukodystrophy caused by mutations that affect the eIF2B protein, which has a…
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