Thursday 16 October, 2025
Objectives: Drug-induced nephrotoxicity accounts for 19-26% of cases of acute kidney injury in hospitalized patients[1]. Nephrotoxicity is closely related with…
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Building a model from comparison of SARS-CoV-2 viral dynamics model proposed since 2020: what are the main differences?
Thursday 16 October, 2025
Introduction: Several mathematical models have been used to characterize viral kinetics of SARS-CoV-2 since 2020. While models may commence with…
Read moreNLME modelling from a causal inference perspective when the dose-exposure-response relationship is confounded by the treatment regimen
Thursday 16 October, 2025
Introduction: When a clinical trial is designed to investigate the effects of a treatment regimen rather than of specific dose…
Read moreMachine learning time-to-event analysis for prediction of 2-month culture conversion with phase 2a information in tuberculosis drug development
Thursday 16 October, 2025
Introduction: In clinical tuberculosis (TB) drug development, phase 2a trials assess early bactericidal activity over two weeks using the time-to-positivity…
Read moreA frailty model for quantifying the association between CompEx risk and variation in lung function in asthma
Thursday 16 October, 2025
Introduction: Seemingly random fluctuations in lung function have previously been shown to be associated with acute exacerbations in asthma (1,…
Read moreA PBPK model of 4β-hydroxycholesterol, an endogenous biomarker for hepatic CYP3A activity.
Thursday 16 October, 2025
Introduction: New drug candidates are tested for CYP3A enzyme induction in vivo using specific probe substrates. However, due to the cost…
Read morePopulation PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases.
Thursday 16 October, 2025
Introduction/Objectives: For women living with chronic inflammatory diseases, adequate disease control during pregnancy is crucial to ensure the best fetal…
Read moreModelling framework to simulate phenotypic results of antiviral PROTACs
Thursday 16 October, 2025
Objectives: Proteolysis-targeting chimeras (PROTAC) are novel chemical concepts taking advantage of the proteasome to degrade target proteins. Compared to PROTACs…
Read moreModeling the influence of antiretroviral treatment initiation time on post-treatment control of HIV infection
Thursday 16 October, 2025
Objectives: The current standard of care for HIV infection involves antiretroviral therapy (ART) [1]. ART is not curative and treatment…
Read moreUsing Fisher Information Matrix to predict covariate effects in forest plots and power of their relevance
Thursday 16 October, 2025
Objectives: One of the aims of pharmacokinetic (PK) and pharmacodynamic (PD) analysis is to identify and quantify the covariates that…
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