Thursday 16 October, 2025
Introduction: Cytokines are inflammatory mediators that play a pivotal role in the initiation and orchestration of the immune response [1]. IL-6,…
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Development of QSP platform model for predicting clinical efficacy and CRS incidence of CD3 bispecifics in STEAP1 Prostate Cancer
Thursday 16 October, 2025
Introduction: CD3 bispecifics are engineered antibodies that bind CD3 on T cells and target antigens on cancer cells (TAAs), activating…
Read moreIntegrating PKPD and Agent-Based Modeling to Explore Tuberculosis Relapse after Treatment.
Thursday 16 October, 2025
Introductions: The immune system’s significance in Tuberculosis (TB) drug development is often underestimated due to experimental complexities. In this study,…
Read moreStudy design optimization in paediatric rare diseases: a case study on empagliflozin in paediatric heart failure
Thursday 16 October, 2025
Objectives: Paediatric heart failure is rare (1-8/100’000), but it represents a relevant health burden. Current therapy is unsatisfactory, with 5-year…
Read moreA Neural Networks-assisted NLME Framework: Case Study on Modeling Platelet Counts
Thursday 16 October, 2025
Objectives: Thrombocytopenia, a frequent adverse event type in cancer therapy, requires clinical platelet management to avoid high-grade thrombocytopenia and to…
Read moreDose rationale for bedaquiline in paediatric patients with multi drug-resistant tuberculosis
Thursday 16 October, 2025
Objectives: At the forefront of the causes of death globally, multi-drug resistant (MDR) tuberculosis (TB) manifests severely in children, posing…
Read moreEtravirine’s Pharmacokinetics Explored: PBPK Modeling and DDI Analysis with Efavirenz for Cancer Treatment
Thursday 16 October, 2025
Objectives: Drug repurposing is an emerging strategy in the quest for new cancer therapies, offering distinct advantages such as leveraging…
Read moreAdvancing Quantitative Systems Pharmacology (QSP) Disease Progression Modeling with Real-World Data: Applications for Patients with Unintentional Weight Loss
Thursday 16 October, 2025
Background: Unintentional weight loss is a symptom of serious disease or illness. Two widely recognized, yet, under diagnosed diseases that…
Read moreHigh-dimension Mechanistic Model Building using LASSO Approaches : Application to Ebola Vaccination
Thursday 16 October, 2025
Introduction Constructing non-linear mixed-effects models (NLMEM) can significantly enhance our understanding of biological processes. In the population approach, NLMEM combine…
Read moreImplications of the changes in the pharmacokinetics of raltegravir in pregnant and post-partum women undergoing antiretroviral therapy against HIV infection.
Thursday 16 October, 2025
Objectives: While integrase inhibitors have become first line antiretroviral therapy for non-pregnant adults [1], there have been few studies supporting…
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