Thursday 7 May, 2026
Introduction/Objectives: Olanzapine is an antipsychotic drug used in the treatment of schizophrenia with oral (PO) and intramuscular (IM) formulations currently…
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SimuRg: an R wrapper package for an AI-based pharmacometrics ecosystem
Thursday 7 May, 2026
Introduction Pharmacometrics analysis can be represented as workflow comprising multiple highly specialized steps that typically include data processing, data digitization,…
Read moreMULTI-AGENT AI APPLICATION FOR INTERACTIVE EXPLORATORY CLINICAL DATA ANALYSIS IN R
Thursday 7 May, 2026
Introduction/Objectives: Exploratory data analysis (EDA) of clinical study data requires rapid iteration on visualizations and data summaries, yet many workflows…
Read moreA PK/PD WORKFLOW TO SUPPORT THE SELECTION OF EMPIRICAL ANTIBIOTIC COMBINATIONS: APPLICATION TO NEONATAL SEPSIS IN LOW- AND MIDDLE-INCOME COUNTRIES
Thursday 7 May, 2026
Introduction Neonatal sepsis remains a major global health challenge, with the highest incidence and mortality occurring in low- and middle-income…
Read morePREDICTION OF DRUG-DRUG INTERACTIONS BETWEEN AYAHUASCA ALKALOIDS AND SSRIS USING PBPK MODELING WITH EXPLORATORY ANALYSIS OF CYP2D6 POLYMORPHISMS AND BREAST MILK EXPOSURE
Thursday 7 May, 2026
Introduction: Ayahuasca is a psychedelic preparation containing N,N-dimethyltryptamine (DMT) and β-carbolines, such as harmine (HRM), a reversible monoamine oxidase A…
Read moreETHNIC-SPECIFIC ONTOGENY OF INTESTINAL DRUG TRANSPORTERS AND METABOLIZING ENZYMES IN THE CHINESE POPULATION: ABSOLUTE PROTEOMICS AND TRANSCRIPTOMIC CHARACTERIZATION ACROSS DEVELOPMENT
Thursday 7 May, 2026
Introduction： Age-related maturation of drug transport and metabolic pathways governs pediatric drug disposition and underpins model-informed extrapolation across developmental stages…
Read morePharmacodynamics of morphine and paracetamol for analgesia after paediatric cardiac surgery: A repeated time-to-event analysis
Thursday 7 May, 2026
Introduction and Objectives: Morphine is widely used as an analgesic after paediatric cardiac surgery, with morphine dosage regimens varying widely…
Read moreClip: a Translational PK/PD Tool to Predict ORR in Solid Tumors using PDX Data
Thursday 7 May, 2026
Introduction: Patient-derived xenograft (PDX) mouse models represent a key preclinical platform for evaluating anticancer drug efficacy, with large-scale PDX encyclopedias…
Read moreAN IN-SILICO APPROACH TO SUPPORT THE ANTIBODY DRUG CONJUGATE (ADC) COMBINATIONS TRIAL DESIGN: IMPACT OF PROPHYLACTIC RESCUE ON EFFICACY
Thursday 7 May, 2026
Introduction & Objectives: Antibody Drug Conjugates (ADCs) have shown reasonable success in several cancer indications in the last decade. However,…
Read moreJoint modeling of tumor size and circulating tumor DNA dynamics to predict overall survival in non-small cell lung cancer
Thursday 7 May, 2026
Objectives: Tumor size-overall survival (TS-OS) modeling is an established approach for predicting OS in oncology clinical trials and thus supporting…
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