Thursday 7 May, 2026
Introduction/Objectives: Structural model discovery in pharmacometrics is a highly iterative, manual, and time-intensive endeavor. Pharmacometricians must continuously propose structural hypotheses,…
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Understanding the effect of administration schedule on the efficacy of olaparib-radiation combination therapy for glioblastoma using Bayesian PKPD modelling
Thursday 7 May, 2026
Introduction: Clinical studies combining molecularly-targeted drugs with radiotherapy (RT) have largely failed to improve patient outcomes in cancer. A potential…
Read moreMODELLING DOSE-RESPONSE AND PATIENT ENROLMENT ACROSS MULTIPLE IVF TREATMENT CYCLES OF FOLLITROPIN DELTA
Thursday 7 May, 2026
Introduction: In vitro fertilisation (IVF) involves stimulating the development of multiple ovarian follicles using follicle-stimulating hormone (FSH) to achieve pregnancy….
Read moreComparative Quantification of Antibiotic Interactions Using Point Estimates, Response‑Surface Models, and Mechanistic Approaches
Thursday 7 May, 2026
Objectives: We aimed to characterise antimicrobial activity and quantify drug interactions in Gram-negative bacteria by applying a range of approaches…
Read moreIN VITRO-IN VIVO EXTRAPOLATION OF ACTIVE INFLUX BY THE PROTON-COUPLED ANTIPORTER FOR PBPK PREDICTIONS OF CNS PHARMACOKINETICS IN EARLY DRUG DISCOVERY: A CASE STUDY ON OXYCODONE
Thursday 7 May, 2026
Objectives: Poor understanding of central nervous system (CNS) target site pharmacokinetics (PK) is a major contributor to high attrition rates…
Read morePOPULATION PHARMACOKINETICS OF BICTEGRAVIR CO-ADMINISTERED WITH RIFAMPICIN IN ADULTS WITH HIV AND TUBERCULOSIS
Thursday 7 May, 2026
Introduction: Bictegravir is an integrase strand transfer inhibitor (INSTI), and a key component of Biktarvy®, a fixed-dose combination containing 50…
Read moreGaussian Process Flows: Accurately characterising drug exposure and effects through Bayesian Inference over mechanistic models.
Thursday 7 May, 2026
Background Recently, NeuralODE-based approaches have emerged as promising tools to learn dynamical systems governing drug exposure and effects directly from…
Read moreA simple algebraic expression can determine if a drug’s clearance is non-specific or target-mediated
Thursday 7 May, 2026
Target-mediated drug distribution (TMDD) is typically classified by accelerated removal of drug after serum concentration drops below a critical level…
Read moreFrom Modeling and Simulation to Personalized Dosing Decisions in IBD: Moving Beyond the Arbitrarily (Pre)Defined Therapeutic Windows and One-Size-Fits-All Dosing Paradigm
Thursday 7 May, 2026
Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the digestive tract. Infliximab, a monoclonal antibody administered intravenously…
Read moreIndividualized Vancomycin Dosing Using Bayesian Modeling in Pediatric Patients with Lymphomas and Leukemias
Thursday 7 May, 2026
Introduction Clinicians are increasingly faced with a wide array of pharmacokinetic (PK) models developed for various patient populations. Selecting the…
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