Thursday 7 May, 2026
Introduction and Objectives: Dose-response meta-analysis (DRMA) has gained considerable attention as an effective approach to synthesize the dose-response relationships reported…
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QUANTITATIVE MAPPING OF FUNCTIONAL CYTOCHROME P450 ACTIVITIES IN ZEBRAFISH EMBRYOS: INTEGRATING PARENT-METABOLITE DATA VIA TOXICOKINETIC MODELING IN NAMS
Thursday 7 May, 2026
Objectives: Genetic homology between zebrafish and human cytochrome P450 (CYP) enzymes has been extensively reported. However, genetic similarity does not…
Read morePOPULATION PHARMACOKINETICS AND EXPOSURE-RESPONSE ANALYSIS OF TECLISTAMAB IN COMBINATION WITH DARATUMUMAB IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO HAVE RECEIVED AT LEAST ONE PRIOR LINE OF THERAPY.
Thursday 7 May, 2026
Objectives: Teclistamab, a bispecific antibody targeting B-cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3), is approved as monotherapy…
Read moreChoosing the Right Exposure Metric: Power and Confounding in Exposure-Response (E-R) Models
Thursday 7 May, 2026
Introduction: As outlined by FDA guidance [1], Exposure-Response (E-R) analyses can support dosage selection and adjustments. When a single response…
Read moreStructured fit-for-purpose evaluation of model-informed precision dosing of mycophenolic acid and tacrolimus in pediatric patients with renal disease
Thursday 7 May, 2026
Objectives Mycophenolic acid (MPA) and tacrolimus are frequently used in kidney diseases like kidney transplantation and nephrotic syndrome. The use…
Read moreNONMEM IMPLEMENTATION OF NEURAL NETWORKS AS FLEXIBLE MODELS OF HAZARD FUNCTIONS IN JOINT MODELS
Thursday 7 May, 2026
Introduction In recent years, machine learning (ML) models have gained popularity in pharmacometrics. However, these two quantitative fields differ markedly…
Read morePopulation Pharmacokinetics of Clesrovimab in Preterm and Full-Term Infants
Thursday 7 May, 2026
Introduction: Clesrovimab (MK-1654), a monoclonal antibody with an extended half-life targeting the respiratory syncytial virus (RSV) fusion protein, is being…
Read moreQPC: Predicting Human Interpretation of VPC Plots
Thursday 7 May, 2026
Objectives: Assess the predictive power of the Quantitative Predictive Check (QPC) as a metric of VPC quality. Methods: QPC is…
Read moreAPPLICATION OF CONTINUOUS-CATEGORICAL IRT MODELLING TO ENHANCE STATISTICAL POWER IN N-OF-1 TRIALS: SIMULATION-BASED EVALUATION
Thursday 7 May, 2026
Background The rapid development of personalized disease-modifying therapies, such as antisense oligonucleotides, has outpaced the evolution of the clinical trials…
Read moreSEEING THE FOREST FOR THE TREES: FOREST PLOTS IN PHARMACOMETRICS
Thursday 7 May, 2026
Introduction: Forest plots (FPs) originate from the field of statistical meta-analysis to visualize individual study effects and overall pooled effects…
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