Thursday 7 May, 2026
Objectives Ocular dexamethasone is licensed as an anti-inflammatory agent for adults, while paediatric use is generally off-label and recommendations are…
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MAKING SPARSE DATA INFORMATIVE: POPULATION PHARMACOKINETICS AND D-OPTIMAL DESIGN FOR ORAL CIPROFLOXACIN IN ADULTS ≥75 YEARS
Thursday 7 May, 2026
Objectives: Oral ciprofloxacin remains one of the few available oral agents with activity against Pseudomonas aeruginosa. However, exposure in older…
Read moreModelling pharmacokinetic-pharmacodynamic of PBTZ169 in glycerol and cholesterol using CFU and MPN as biomarkers
Thursday 7 May, 2026
Introduction/Objectives: Mycobacterium tuberculosis undergoes metabolic and physiological adaptations to survive in the diverse microenvironments of granulomas and cavities within the…
Read moreAI AUTOMATION MEETS PBPK: AN R SHINY APPLICATION WITH LARGE LANGUAGE MODEL INTEGRATION FOR EFFICIENT PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL REPORTING
Thursday 7 May, 2026
Objectives: Physiologically based pharmacokinetic (PBPK) reporting often depends on manual collation of PK parameters across numerous simulation outputs and substantial…
Read morePopulation PK/PD analysis of roginolisib in healthy participants using the basophil activation test to determine the PI3Kδ occupancy.
Thursday 7 May, 2026
Introduction and Objectives: The highly selective, oral allosteric modulator of PI3Kδ, roginolisib (IOA-244), blocks the activity of PI3Kδ-dependent signalling, in…
Read moreDesign Evaluation and Optimisation with Discrete Covariates and Inter-Occasion Variability in Nonlinear Mixed Effects Models: The R Package PFIM 7.1
Thursday 7 May, 2026
Objectives Several packages for design evaluation and optimisation in pharmacometrics are based on the Fisher Information Matrix (FIM). The were…
Read moreBIDIRECTIONAL CONVERSION BETWEEN MRGSOLVE AND RXODE2 FOR PHARMACOMETRIC MODELS
Thursday 7 May, 2026
Objectives Pharmacometric models implemented in mrgsolve [1] and rxode2 [2] are increasingly used for simulation and exploratory analyses in R…
Read morePrognostic value of organ-specific tumor dynamics on overall survival across nine cancer types: a two-stage individual patient data meta-analysis of multilevel joint models
Thursday 7 May, 2026
Objectives: Overall survival (OS) is the main endpoint in oncology randomized clinical trials (RCTs), yet its late observation limits the…
Read moreUse of a population pharmacokinetic model to support dose selection for Phase 2a study with AZD4144 IV treatment in participants with acute kidney injury
Thursday 7 May, 2026
Objectives: AZD4144 is a small‑molecule that inhibits the NLRP3 inflammasome, which is currently in clinical development for the treatment of…
Read moreComparative Acute Kidney Injury Risk Across Antibiotics Commonly Used for Severe Infections in Hospitalized Patients: A Time-Varying Causal Analysis
Thursday 7 May, 2026
Introduction / Objectives Antibiotics are among the most frequently prescribed medications in hospitalized patients, and several agents have been associated…
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