Thursday 7 May, 2026
Introduction: Despite making up more than 60% of the world’s population, Asian genomes are undercharacterized. A large-scale whole genome sequencing…
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DIALYSATE-GUIDED MODEL-INFORMED PRECISION DOSING OF MEROPENEM DURING CRRT
Thursday 7 May, 2026
Introduction: Continuous renal replacement therapy (CRRT) is essential for hemodynamically unstable ICU patients with acute kidney injury, but it significantly…
Read moreMECHANISTIC MODELLING OF TARGETED-ANTIBACTERIAL-PLASMIDS TRANSFER VIA BACTERIAL CONJUGATION TO GUIDE DESIGN OF RESISTANCE REVERSAL STRATEGIES
Thursday 7 May, 2026
1. Objectives Antimicrobial resistance is a priority for the World Health Organization and was directly responsible for 1.27 million deaths…
Read moreModeling of Vancomycin-Induced Changes in Serum Creatinine to Improve Prediction of Acute Kidney Injury
Thursday 7 May, 2026
Introduction: Vancomycin is an antibiotic commonly used in a hospital setting to treat Methicillin Resistant Staphylococcus Aureus (MRSA). The occurrence…
Read moreModel-Informed Design of Interim Analysis for a PK Bridging Study and Optimization of Its Operating Characteristics
Thursday 7 May, 2026
Introduction PK bridging studies are routinely conducted to extrapolate efficacy from one population in which efficacy has been established (reference…
Read moreFOUR-SNP NAT2 GENOTYPING OUTPERFORMS TAG-SNP AND MIXTURE MODELS FOR HIGH-DOSE ISONIAZID PK
Thursday 7 May, 2026
Objectives Isoniazid is used at standard doses of 4–6 mg/kg for drug-susceptible tuberculosis and at higher doses of 10–15 mg/kg…
Read moreA POTENTIAL COST OF BLOCK-DIAGONAL Ω: BIASED DOSE-RESPONSE ESTIMATES IN THE PRESENCE OF EXPOSURE-RESPONSE CONFOUNDING
Thursday 7 May, 2026
Introduction: In pharmacometrics, it is often (implicitly) assumed that the exposure-response relationship in a dose randomized study is unconfounded, at…
Read morePrediction of Myotoxicity, Nephrotoxicity, and Hepatotoxicity Among Patients Receiving Lipid-Lowering Agents: A FAERS-Based Pharmacovigilance Study
Thursday 7 May, 2026
Introduction / Objectives Using data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS), a comprehensive assessment…
Read moreAPPLICATION OF PHARMACOKINETIC MODELING AND SIMULATION IN THE BIOEQUIVALENCE ASSESSMENT OF GENERIC DRUGS: THE CASE OF LUMEFANTRINE
Thursday 7 May, 2026
INTRODUCTION Generic drugs play a crucial role in contemporary healthcare systems [1]. Their marketing authorization requires the demonstration of bioequivalence…
Read morePRECLINICAL PBPK MODELING FOR PERSONALIZED THERAPY AND DOTA-TATE-BASED RADIOPHARMACEUTICAL MODULARITY
Thursday 7 May, 2026
Objective. Peptide receptor radionuclide therapy (PRRT) with [¹⁷⁷Lu]Lu-DOTA-TATE is an established treatment for somatostatin receptor type 2 (SSTR2)-expressing neuroendocrine tumours,…
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