Thursday 7 May, 2026
Introduction Pharmacometrics analyses typically require modelers to apply multiple methodologically distinct functions across diverse tools and environments, prompting substantial reformatting…
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Does Nonlinear Absorption of Oral Misoprostol Challenge Guideline-Based Dosing in Late Pregnancy Cervical Ripening? A Population Pharmacokinetic Model to Resolve.
Thursday 7 May, 2026
Introduction: Misoprostol is the first-line agent for cervical ripening in late pregnancy, with oral administration increasingly superseding traditional vaginal routes…
Read moreINTEGRATED POPULATION PHARMACOKINETIC-PHARMACODYNAMIC-EFFICACY ANALYSIS OF ENAVOGLIFLOZIN: LINKING EXPOSURE, GLUCOSURIA, AND HBA1C REDUCTION IN TYPE 2 DIABETES
Thursday 7 May, 2026
Objectives (167 words): Sodium-glucose cotransporter 2 (SGLT2) inhibitors are oral antihyperglycemic agents for the treatment of type 2 diabetes (T2D)…
Read moreApplying Sampling Importance Resampling to Improve Simcyp PBPK Models Predictions Performance
Thursday 7 May, 2026
Physiologically based pharmacokinetic (PBPK) modeling is a powerful tool for integrating in vitro and in vivo data to predict drug…
Read moreA semi-mechanistic intranasal PBPK framework implemented in MoBi
Thursday 7 May, 2026
Objectives Intranasal delivery enables rapid systemic exposure, avoids hepatic first-pass metabolism, and can improve tolerability relative to oral and parenteral…
Read morePYRAZINAMIDE POPULATION PHARMACOKINETICS IN ADULTS WITH DRUG-RESISTANT TUBERCULOSIS: THE ROLE OF ALLOMETRIC SCALING
Thursday 7 May, 2026
Objective: Pyrazinamide is a key sterilizing agent in first- and second-line tuberculosis (TB) treatment [1]. Current WHO guidelines recommend weight-band…
Read moreProspective dose optimization for individual patients by successive application of empirical Bayesian estimation and OptiDose including uncertainty quantification: Application to pediatric Graves’ Disease
Thursday 7 May, 2026
Objectives In pediatric thyroid care, precise treatment is essential, as hormone imbalance can impair neurodevelopment, cognition, and growth. Despite guideline-based…
Read moreCOMPARISON OF MASPECTRA AND NONMEM FOR POPULATION PHARMACOKINETIC MODELING: AN ABSK-011 (IRPAGRATINIB) CASE STUDY
Thursday 7 May, 2026
Note: H. Zheng and C. Wang contributed equally to this research. Introduction: Maspectra [1] is a software platform for modeling…
Read moreMECHANISTIC TARGET-MEDIATED POPULATION PK/PD MODELLING OF REGN7508Cat ACROSS HEALTHY VOLUNTEERS AND ORTHOPEDIC SURGERY POPULATIONS WITH TRANSLATIONAL EVALUATION IN PATIENTS WITH PICCS
Thursday 7 May, 2026
Introduction: REGN7508Cat is a high-affinity human monoclonal antibody targeting the catalytic domain of factor XI (FXI). Given the target-mediated nature…
Read morePopulation PK Modelling of Intranasal Midazolam Incorporating Maturation-Informed Paediatric Scaling
Thursday 7 May, 2026
Objectives Midazolam is a short-acting benzodiazepine widely used for indications such as conscious sedation and treatment of epileptic seizures [1]….
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