Thursday 16 October, 2025
Introduction: Worldwide, there are an estimated number of 569,800 cervical cancer cases per year due to an infection with human…
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Population pharmacokinetic modeling of esaxerenone: a novel nonsteroidal mineralocorticoid receptor blocker
Thursday 16 October, 2025
Objectives: Esaxerenone is a novel nonsteroidal mineralocorticoid receptor blocker that was approved as an antihypertensive agent in Japan in 2019….
Read moreModel-informed precision dosing for tamoxifen therapy in breast cancer patients: Comparison of different target attainment metrics
Thursday 16 October, 2025
Objectives: In 2011, Madlensky et al. [1] established an efficacy threshold for endoxifen, (ENDX), the active metabolite of tamoxifen (TAM)….
Read morePopulation quantitative systems pharmacology model of distinct CAR-T cell phenotypes and CD19-specific metabolic tumour volume reveals sources of high pharmacokinetic variability and overall survival
Thursday 16 October, 2025
Objectives: Chimeric antigen receptor (CAR)-T cell therapy has increased the prognosis of patients with relapsed/refractory Non-Hodgkin lymphoma (NHL) significantly [1–3]….
Read moreModel-informed early clinical development of BI-1808, a novel monoclonal antibody to tumor necrosis factor receptor 2
Thursday 16 October, 2025
Objectives: BI-1808 is a novel immunotherapy targeting tumor necrosis factor receptor 2 (TNFR2), which is abundantly expressed on tumor-resident regulatory…
Read morePharmacokinetic/Pharmacodynamic framework to support the subcutaneous dosing regimen of nemolizumab in subjects with Prurigo Nodularis
Thursday 16 October, 2025
Introduction: Nemolizumab (NEMO) is a humanized anti-interleukin-31 (IL-31) receptor A monoclonal antibody. This novel mechanism of action is expected to…
Read moreEvaluation of four distinct weighting schemes in a model averaging and selection approach in model-informed precision dosing of continuously infused vancomycin
Thursday 16 October, 2025
Objectives: Optimal dosing of the antibiotic vancomycin in potentially life-threatening infections can be supported by population pharmacokinetic (PK) models. Although the…
Read morePredictive performance of population pharmacokinetic models for Bayesian forecasting of coagulation factor VIII in hemophilia A
Thursday 16 October, 2025
Objectives: Factor VIII is an essential coagulation glycoprotein and commonly substituted in the treatment of hemophilia A, an x-linked inherited…
Read moreAluminium biokinetics: Elucidating the speciation kinetics of the aluminium-citrate system in vitro.
Thursday 16 October, 2025
Objectives: As an element, aluminium (Al) does not undergo metabolism in biological systems, but rather distributes into a plethora of…
Read morePhysiologically based pharmacokinetic modeling of the dabigatran antidote idarucizumab
Thursday 16 October, 2025
Introduction: The direct oral anticoagulant dabigatran is an important alternative to warfarin, as it has predictable pharmacokinetics (PK), anticoagulant effects…
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