Thursday 16 October, 2025
Introduction: COPD clinical trials aimed at evaluating long-term treatment effects on exacerbations often suffer from a high rate of patient discontinuations….
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Evaluating the influence of genotype on warfarin dose predictions made using a theory-based PKPD model.
Thursday 16 October, 2025
Objectives: Warfarin continues to be the mainstay of oral anticoagulation therapy, however, a narrow therapeutic range poses a barrier to…
Read moreM-EASE-2: A Modelling and simulation study conducted to further characterize the efficacy of low-dose Empagliflozin as Adjunctive to inSulin thErapy (M-EASE) in Type 1 Diabetes Mellitus (T1DM)
Thursday 16 October, 2025
Objectives: The objective of this modelling and simulation study was to further characterize the empagliflozin (EMPA) 2.5 mg qd dose…
Read moreApplication of physiologically-based pharmacokinetic model to mechanistically predict increased tumour uptake of paclitaxel in cancer patients
Thursday 16 October, 2025
Objectives: Tubulin targeting drugs such as paclitaxel exert their effect intracellularly within tumor, thus sufficient intracellular drug concentrations are essential…
Read moreEvaluation of Parameter Estimation when Fitting a Mixture Model with Covariate Effects using NONMEM
Thursday 16 October, 2025
Objectives: It has been in doubt whether parameter estimates are reliable when fitting a mixture model to pharmacokinetic data using…
Read morePharmacogenetics-Based Population Pharmacokinetic Analysis for Dosing Optimization of Ritonavir-Boosted Atazanavir in Thai adult HIV-Infected Patients
Thursday 16 October, 2025
Objectives: In Thailand, Ritonavir-Boosted Atazanavir (ATV/RTV) is a preferred protease inhibitor based-regimen for the treatment of HIV infection. The pharmacokinetics…
Read moreModelling of Dose-Response-Time Data Using a Population k-PD approach for Linerixibat, a Locally Acting Small Molecule with Minimal Systemic Absorption
Thursday 16 October, 2025
Objectives: The increase in systemic bile acids (BA) observed in primary biliary cholangitis (PBC) patients may play a causal role in…
Read morePopulation Pharmacokinetic Modeling of Quetiapine Lipid Core Nanocapsules in a Neurodevelopmental Animal Model of Schizophrenia
Thursday 16 October, 2025
Introduction: High variability in chronic SCZ response to treatment may be partially related to blood-brain barrier (BBB) dysfunction caused by…
Read moreQuantitative modeling of inter-lesion and inter-organ variability of tumor size
Thursday 16 October, 2025
Objectives: In metastatic cancer, the growth and drug-induced shrinkage of individual tumor lesions may be highly dependent on the microenvironment…
Read moreA methodology to estimate population pharmacokinetic parameters from aggregate concentration-time data and its application to gevokizumab.
Thursday 16 October, 2025
Objectives: The aim of the present study was to develop and assess the performance of a methodology to estimate the…
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