Thursday 16 October, 2025
Objectives: Non-random dropout is common in clinical studies focusing on tumor growth dynamics. This phenomenon results in an underestimation of…
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A QSP model to inform dose decision and fast track candidate lead in mRNA vaccines development
Thursday 16 October, 2025
Introduction: Over the past two years mRNA vaccine platforms have proven to be a formidable tool to quickly develop and deploy…
Read moreDevelopment of predictive model for acute kidney injury after minimally invasive partial nephrectomy
Thursday 16 October, 2025
Objectives: The incidence of renal cell carcinoma is increasing in worldwide and surgical excision via partial nephrectomy or radical nephrectomy…
Read moreA mechanism-based pharmacokinetic/pharmacodynamic model to evaluate the mutual relationships between YH4808, a novel K+-competitive acid blocker, and intragastric pH in humans
Thursday 16 October, 2025
Introduction: YH4808 is a highly potent, selective and reversible potassium-competitive acid blocker of the H+/K+-ATPase under development to treat gastric acid-related…
Read morePhysiologically-based pharmacokinetic model for itraconazole and its metabolites: the importance of parameter sensitivity analysis
Thursday 16 October, 2025
Introduction: : Itraconazole has emerged as one of the best candidates to use as a standard CYP3A4 inhibitor in clinical…
Read moreSimvastatin disposition described by physiologically based pharmacokinetics: Does choice of applied PBPK platform matter?
Thursday 16 October, 2025
Introduction/Objectives: The use of complex whole-body physiologically-based pharmacokinetic (PBPK) models in drug discovery and development is facilitated by the development…
Read moreInvestigating the relationship between Lactate Dehydrogenase and the occurrence of Chronic Lower Respiratory Diseases
Thursday 16 October, 2025
Introduction: Chronic Lower Respiratory Diseases (CLRDs) are a class of diseases that affect the trachea, bronchioles and alveoli, e.g. emphysema, bronchitis…
Read moreTowards personalised medicine in Non-Small Cell Lung Cancer: design of a forecasting model of disease-progression to overall survival.
Thursday 16 October, 2025
Objectives: Lung cancer is the second most common cancer and the leading cause of cancer related death worldwide. In the…
Read moreObesity and NAFLD activity score increase rate of fibrosis progression in a continuous-time Markov modelling of fibrosis progression in a long-term follow-up biopsy NAFLD cohort.
Thursday 16 October, 2025
Objectives: Nonalcoholic fatty liver disease (NAFLD) is now one of the most common causes of liver-related morbidity and mortality. The…
Read moreEvaluation of competitive differentiation of novel therapies and the impact of patient variability on efficacy in a psoriasis QSP platform
Thursday 16 October, 2025
Introduction Psoriasis is a chronic, debilitating autoimmune skin disease affecting ~2% of the population with itching, thickened, red scaly skin,…
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