Thursday 16 October, 2025
Background In oncology, the FDA requests for more rational derivation of optimal doses [1]. A first step to dose optimisation…
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Population pharmacokinetics of Haemate P describing the interaction between factor VIII and Von Willebrand Factor levels in perioperative patients with von Willebrand Disease
Thursday 16 October, 2025
Objectives: Previous studies indicate that 65 to 91% of patients with von Willebrand Disease (VWD) treated with a von Willebrand…
Read moreRelationship between factor VIII activity levels and bleeding for rFVIII-SingleChain in patients with severe hemophilia A
Thursday 16 October, 2025
Objectives: Severe and some moderate severe patients with hemophilia A are often prophylactically treated with factor VIII (FVIII) concentrates. Publications…
Read morePre- and postnatal maturation are important for fentanyl exposure in preterm and term newborns: a pooled population pharmacokinetic study
Thursday 16 October, 2025
Objectives: Fentanyl is a commonly used opioid in neonatal intensive care units (NICU) to prevent and ameliorate severe pain. Given…
Read moreMaturation of formation clearance of paracetamol metabolites after intravenous paracetamol dosing in preterm neonates
Thursday 16 October, 2025
OBJECTIVES: Intravenous paracetamol (PCM) is increasingly used to control mild-to-moderate pain in preterm neonates, yet it’s use is off-label in…
Read moreWhen will the glomerular filtration rate in preterm neonates catch up to their term peers?
Thursday 16 October, 2025
Introduction Glomerular filtration rate (GFR) plays an important role in the clearance of drugs in neonates. Characterizing its maturation provides…
Read morePhysiologically Based Pharmacokinetic Modeling of Dasatinib to Describe Enzyme-Mediated and pH-Dependent Drug–Drug Interaction Scenarios
Thursday 16 October, 2025
Introduction: The clinical application of dasatinib – a second-generation tyrosine kinase inhibitor – in the treatment of chronic myeloid leukemia is…
Read morePhysiologically based pharmacokinetic (PBPK) modeling of (E)-clomiphene drug-drug-gene interactions with CYP2D6 and clarithromycin
Thursday 16 October, 2025
Introduction: Polycystic ovary syndrome (PCOS) is one of the major causes of female infertility, which affects about 15-20% of couples…
Read moreA Physiologically Based Pharmacokinetic Model of Atorvastatin Acid Predicting CYP3A4 and OATP1B Drug–Drug Interactions
Thursday 16 October, 2025
Introduction: The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor atorvastatin is a widely prescribed statin for managing dyslipidemia, a well-established risk factor…
Read moreThe impact of drug properties and severity of obesity on renal clearance through glomerular filtration and active tubular secretion
Thursday 16 October, 2025
Objectives: Obesity is a global health concern, but its influence on renal clearance (CLr) of drugs remains unclear. Obesity may…
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