Thursday 16 October, 2025
Introduction: Daptomycin is authorized for the treatment of complicated skin and soft tissue infections (IPPBc), right-sided infective endocarditis (EID) due…
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Non linear mixed effects modelling of tumour interactions with the adaptive immune response during Radiotherapy in combination with anti-PDL1 or Olaparib.
Thursday 16 October, 2025
Objectives: Preclinical studies have shown that that it is possible to synergistically increase the efficacy of radiotherapy (RT) using additional…
Read moreA QSP approach to investigate the glucose-insulin dynamic following dapagliflozin treatment in patients with type 2 diabetes mellitus
Thursday 16 October, 2025
Introduction: Dapagliflozin is a highly potent, sodium-glucose cotransporter 2 (SGLT2) selective inhibitor approved for use in patients with type 2…
Read moreThe multivariate baseline and longitudinal biomarker analysis for the survival prediction in NSCLC by means of joint modeling
Thursday 16 October, 2025
Objectives: Tumor size is a validated surrogate biomarker for assessment of treatment efficiency and survival in patients with non-small cell lung…
Read moreMathematical modeling of autoimmune diseases: a systematic review and analysis for advancing therapeutic development
Thursday 16 October, 2025
Introduction: The intricate pathogenesis and etiology of autoimmune diseases (ADs) pose challenges to the research and development of novel therapeutic…
Read moreTorsten: Stan functions for pharmacometric applications – Improvements and new R interface workflow
Thursday 16 October, 2025
Objectives: Stan is a widely used, open-source, probabilistic programming language and Bayesian inference engine [1]. It provides a general model…
Read moreSemi-mechanistic model for the antitumor response of a combination cocktail of immune-modulators in non-inflamed (cold tumors)
Thursday 16 October, 2025
Objectives: Immune checkpoint inhibitors administered as single agent have demonstrated clinical efficacy in certain tumor types [1,2]. However, when treating…
Read moreApplication of model informed drug development to pediatric program for ligelizumab in Chronic Spontaneous Urticaria
Thursday 16 October, 2025
Introduction: The paediatric development program for ligelizumab in Chronic Spontaneous Urticaria (CSU) is an example of how modelling and simulation…
Read moreInvestigation of the design of the capsaicin cough challenge test
Thursday 16 October, 2025
Introduction: The capsaicin cough challenge test has been used for many years to elucidate the mechanisms of cough and evaluate…
Read moreDevelopment of mechanistic models for analysis and interpretation of cough challenge test data
Thursday 16 October, 2025
Introduction: Coughing is a worldwide health problem and is associated with comorbidities which have a significant impact on the quality…
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