Thursday 16 October, 2025
Objectives: Current tuberculosis (TB) regimen development is in dire need of rapid innovation; the current 6-month standard of care has…
Read moreAbstracts
Population Pharmacokinetic Analysis and Probability of Target Attainment Simulations of Pivmecillinam for the Treatment of Uncomplicated Urinary Tract Infection
Thursday 16 October, 2025
Introduction: A population pharmacokinetic (PopPK) model was developed to characterize mecillinam (MEC) pharmacokinetics (PK) and urine exposure after intravenous (IV)…
Read moreA Physiologically Based Pharmacokinetic (PBPK) Model of Sildenafil to Predict Exposure in Pregnant Females. What is missing?
Thursday 16 October, 2025
Objectives: Sildenafil (S), a potent vasodilator, has recently been shown to reduce the incidence of operative delivery for intrapartum fetal compromise…
Read morePharmacokinetic and pharmacodynamic modelling of different oral paclitaxel formulations co-administered with ritonavir.
Thursday 16 October, 2025
Introduction: The oral administration of the widely used anticancer agent paclitaxel has several benefits compared to the conventional intravenous (IV)…
Read morePredicting the impact of healthy aging on the brain pharmacokinetic profiles using a translational modeling approach
Thursday 16 October, 2025
Objectives: Unbound drug concentrations at brain extracellular (ECF) and intracellular (ICF) target sites are the drivers of CNS drug (side)…
Read moreIntegration of the LeiCNS-PK3.0 PBPK framework and multiscale data to select anti-COVID19 drugs with favorable brain pharmacokinetics
Thursday 16 October, 2025
ObjectivesIncreasing concerns about the CNS involvement in COVID-19 have been raised by the associated neurological manifestations [1–3]. SARS-CoV-2 has also…
Read morePharmacokinetics Optimization of Phase 2b/3 Study in Infants to Support the Development an RSV Monoclonal Antibody (MK-1654)
Thursday 16 October, 2025
Objectives: MK-1654 is a monoclonal antibody being developed for the prevention for Respiratory Syncytial Virus (RSV) in infants. A Phase…
Read moreCosts of pemetrexed-associated neutropenia and the budget impact of pemetrexed dose individualization
Thursday 16 October, 2025
Objectives: Pemetrexed is an antifolate used in the treatment of lung cancer, in combination with other agents or as monotherapy….
Read moreBayesian modelling of individual lesions dynamics and survival to characterize response to immunotherapy cancer treatments
Thursday 16 October, 2025
Context: In oncology clinical trials, a common marker of tumor size is the Sum of Longest Diameters (SLD) of target…
Read moreJoint modelling of individual target lesions and survival to characterize the variability in the response to immunotherapy versus chemotherapy in advanced bladder cancer
Thursday 16 October, 2025
Context: In oncology, a common marker of tumor burden is the Sum of Longest Diameters (SLD) of target lesions, and…
Read more