Thursday 16 October, 2025
Objectives: Pemetrexed is a widely used cytostatic agent for the treatment of non-small cell lung cancer (NSCLC) and mesothelioma. Dosing of…
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Population pharmacokinetics of cefazolin in maternal and umbilical cord plasma, and exposure in term neonates
Thursday 16 October, 2025
Introduction: Intrapartum administration of cefazolin, a first-generation cephalosporin, is used to prevent vertical transmission of Group B Streptococcus (GBS) in…
Read moreA patient-level population pharmacokinetics meta-analysis of three posaconazole formulations in immunocompromised paediatric patients
Thursday 16 October, 2025
Introduction: Posaconazole is active against invasive Aspergillus and Candida infections [1]. Based on its use for prophylaxis against and treatment…
Read moreModel-based dose optimisation of intravenous posaconazole for treatment of patients with invasive aspergillosis in the intensive care unit
Thursday 16 October, 2025
Introduction: Posaconazole is a broad-spectrum triazole antifungal drug used for prophylaxis and treatment of invasive fungal infections in critically ill…
Read moreAnidulafungin exposure and population pharmacokinetics in critically ill patients with invasive candidiasis
Thursday 16 October, 2025
Introduction: Anidulafungin is an echinocandin, recommended as a first-line treatment of invasive Candida infections in critically ill patients (1). Pharmacokinetic…
Read morePredicting lung exposure of intramuscular niclosamide as an antiviral agent against COVID-19 using power-law-based pharmacokinetic modeling
Thursday 16 October, 2025
Background: Niclosamide, a potent anthelmintic agent, has been found to be effective against COVID-19 in recent studies [1-3], and a…
Read moreFractal kinetic implementation in population modeling
Thursday 16 October, 2025
Objectives: Compartment modeling is a widely accepted technique in the field of pharmacokinetic analysis. However, conventional compartment modeling is commonly…
Read moreWeb based platform for clinical pharmacokinetic consultation service (CPCS) with Non-linear Mixed Effect Model
Thursday 16 October, 2025
Objectives: Demand of individualized pharmaceutical intervention is on growing in certain clinical situations, yet majority of existing applications used for…
Read moreContainerized NONMEM and its assistant software in R development environment
Thursday 16 October, 2025
Objectives: Nonlinear mixed effect modeling (NONMEM) for pharmacologic problem is a multidiscipline, highly computer-power demanding and time-spending task, so that…
Read moreStratified medicine approaches for the treatment of drug-susceptible tuberculosis: a novel phase 2 trial design
Thursday 16 October, 2025
Objectives: A 17-week rifapentine-moxifloxacin-based regimen has been recently shown to have noninferior efficacy to the standard 26-week regimen for the…
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