Thursday 16 October, 2025
Introduction: As of May 2021, no antiviral drug regimen has proved effective against SARS-CoV-2. With the pandemic showing no signs of…
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Development of a priori dosing nomograms for daptomycin in patients at Swiss university hospitals
Thursday 16 October, 2025
Objectives: Daptomycin is a cyclic lipopeptide with activity against gram-positive bacteria (e.g. Staphylococcus spp., Enterococcus spp.) [1]. This antibiotic has dose-linear pharmacokinetics and…
Read moreOral ivermectin population pharmacokinetics modeling in venous plasma in healthy study participants in Kenya in preparation of BOHEMIA cluster randomized controlled trial
Thursday 16 October, 2025
Introduction: Malaria remains a significant global public health problem although this infectious disease is preventable and treatable. Despite the large-scale…
Read moreIntroducing a novel analytical framework for risk stratification of real-world data with survival and unsupervised machine learning. A small cell lung cancer SCLC study
Thursday 16 October, 2025
Objectives: Stratification of patients to predict accurate prognostic outcomes and improve treatment selection is a crucial challenge in oncology [1]….
Read morePopulation pharmacokinetics and pharmacodynamics of intravenous immunoglobulin treatment in patients with Guillain-Barré syndrome
Thursday 16 October, 2025
Introduction: The Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy frequently triggered by a preceding infection. Clinically GBS is characterized…
Read moreDevelopment of a primary Sjogren’s Syndrome (pSS) quantitative systems pharmacology (QSP) model linking mechanistic pathways to clinical scores.
Thursday 16 October, 2025
Introduction: Primary Sjogren’s syndrome (pSS) is a heterogeneous autoimmune disease characterized by lymphocytic infiltrates and functional impairment of exocrine glands,…
Read moreDevelopment of a systemic lupus erythematosus (SLE) QSP model linking systemic biomarkers to cutaneous clinical score (CLASI) outcomes.
Thursday 16 October, 2025
Introduction: Evaluation of novel therapies or interventions for regulatory approval depends on the measurement of clinically relevant and often semi-quantitative…
Read moreMachine learning for covariate selection and prediction of pharmacokinetic data illustrated with rifampicin
Thursday 16 October, 2025
Objectives: Pharmacometrics (PMX) plays a vital role in various areas ranging from model-informed drug development, regulatory decision-making to model-informed precision…
Read moreModel-based experimental design recommendations for in vivo studies of the novel anti-tuberculosis drug MPL-447 improve characterization of PK and PD
Thursday 16 October, 2025
Introduction: The novel mycobacterial membrane protein large 3 (MmpL3) transporter inhibitor MPL-447 is being developed for tuberculosis (TB) treatment by…
Read moreProspective evaluation of a novel model-based dosing guideline for gentamicin in preterm and term neonates
Thursday 16 October, 2025
Objectives: One of the most commonly used prophylactic antibiotics at the neonatal intensive care unit (NICU) is gentamicin. It is mainly…
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