Thursday 16 October, 2025
Objectives: Hyperglycemia (HG) during acute ischemic stroke (AIS) is associated with poor outcomes. Diabetes mellitus (DM) is an independent predictor…
Read moreAbstracts
Characterization of SARS-CoV-2 variants of concern viral dynamics in non-human primates
Thursday 16 October, 2025
Introduction Since the beginning of the pandemic several SARS-CoV-2 variants have emerged and although most of them vanished quickly, some…
Read moreDeveloping a model of SARS-CoV-2 viral dynamics under monoclonal antibody treatment.
Thursday 16 October, 2025
Introduction: After more than a year of an unprecedented pandemic, it remains critical to find effective anti-viral strategies against SARS-CoV-2…
Read moreEffect of CYP2D6 genotype on pharmacokinetics and pharmacodynamics of carvedilol for the heart rate reduction in healthy subjects
Thursday 16 October, 2025
Objectives: Carvedilol is an adrenergic receptor antagonist and used as first-line therapy for cardiovascular disease including hypertension. It is mainly…
Read moreModel Averaging Across Parametric and Non-Parametric Methods as an Aid for Clinical Decision Making
Thursday 16 October, 2025
Objectives: Randomized clinical trials (RCTs) are the main tool to generate patient-level data. The main analysis method of such data is…
Read moreParametric and Non-Parametric Methods in Clinical Decision Making- A Comparison of Bias and Precision using Real Clinical Data
Thursday 16 October, 2025
Objectives: Non-parametric Mixed Models for Repeated Measures (MMRM) have evolved to be the gold standard for disease progression data analysis…
Read moreA Semi Parametric Method for the Estimation of End of Treatment Effect
Thursday 16 October, 2025
Objectives: End of treatment effect is a commonly used endpoint in Randomized Clinical Trials (RCTs). Several methods are used for…
Read moreEvaluating two strategies for the design of pediatric pharmacokinetic studies
Thursday 16 October, 2025
Objectives: Designing pediatric clinical trials are complicated by the large range of body sizes and developmental changes in the population…
Read moreRelative bioavailability of delamanid dispersed in water in healthy volunteers
Thursday 16 October, 2025
Objectives: Delamanid is a nitro-dihydro-imidazooxazole antibiotic which derives its antimycobacterial activity from inhibiting mycolic acid synthesis. A delamanid tablet of…
Read moreA novel approach to evaluate the design of pediatric PK studies focused on accurate dose selection
Thursday 16 October, 2025
Objectives: A commonly used criterion to justify the design of a pediatric PK study is that the study must be…
Read more