Thursday 16 October, 2025
Introduction: Dolutegravir (DTG) and lamivudine (3TC) fixed dose combination (FDC, 50/300 mg) is marketed as DOVATO which provides a novel,…
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Assessing the impact of choosing different estimated glomerular filtration rate (eGFR) equations on pharmacokinetic models: A proof-of-concept study with illustrative examples
Thursday 16 October, 2025
Objectives: Renal function is assessed using the glomerular filtration rate (GFR), determined by measuring the elimination of exogenous biomarkers that…
Read moreA fully hierarchical Bayesian approach to sequentially update population parameter uncertainty in MIPD
Thursday 16 October, 2025
Introduction: In model-informed precision dosing (MIPD), PK/PD models are used to predict therapy outcome based on patient characteristics and data…
Read moreSimple and illustrative model to study Bayesian hierarchical modelling approaches for continued learning in model-informed precision dosing
Thursday 16 October, 2025
Introduction: In model-informed precision dosing, PK/PD models are used to predict therapy outcomes based on patient characteristics and data from…
Read moreA Quantitative Systems Pharmacology Model for Bedside Optimization of ACE Inhibitor Dose Scheduling in Veterinary Cardiology
Thursday 16 October, 2025
Introduction: Similar to humans, the renin-angiotensin-aldosterone-system (RAAS) plays a central role in the pathophysiology of congestive heart failure (CHF) in…
Read moreSolving ODEs in a Bayesian context: challenges and opportunities
Thursday 16 October, 2025
Introduction: Doing full Bayesian inference on ODE-based pharmacometrics models is known to be computationally intensive, although the exact nature of…
Read moreA physiologically based pharmacokinetic modelling and “virtual twin” simulation approach for the prediction of busulfan exposure in young children undergoing hematopoietic stem cell transplantation.
Thursday 16 October, 2025
Introduction: Busulfan (Bu) remains one of the key components of conditioning regimens in pediatric hematopoietic stem cell transplantation. Typical administration…
Read morePK/PD modelling of the effect of nanoencapsulated quetiapine on cortical dopamine concentrations in schizophrenia phenotyped rats
Thursday 16 October, 2025
Introduction: Schizophrenia (SCZ) is a chronic mental disorder associated with a dysregulation in brain dopaminergic system[1]. Quetiapine (QTP) is an…
Read moreQuantitative Systems Pharmacology of Interferon Alpha Administration and its induced cellular response in mice
Thursday 16 October, 2025
Introduction: Drug development requires a mechanistic understanding of drug action to ensure the safety and efficacy of new therapies. However,…
Read moreInforming the selection of clinically relevant pharmacokinetic target range for Therapeutic Drug Monitoring (TDM) of sunitinib: a pharmacometric simulation framework
Thursday 16 October, 2025
Objectives: Sunitinib is commonly used to treat gastrointestinal stromal tumors (GIST) and metastatic renal cell carcinoma (mRCC). With sunitinib exposure…
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