Saïk Urien
INSERM, Laboratoire de Pharmacologie, Faculté de Médecin, F94010 Créteil
This project is developed for population pharmacokinetic modeling of experimental data. The program is written in Pascal language and runs on the high-level Windows® graphical interface. This provides a user-friendly tool that allows easy and fast modelisation of the data. The main improvements of this new version are:
- The formulation of a pharmacokinetic parameter as a function of different covariates is much more flexible: any function can be simply written in a grid line and readily compiled by the program.
- The computation is much more faster,
- A 32-bit version (Windows-95® Windows-NT®) will be available.
The population pharmacokinetic parameters, the inter-individual variabilities around these parameters and the intra-individual variability for the time-courses are estimated by the minimisation of the extended least-squares (ELS) criterion via the use of Simplex or Powell algorithms. Several statistical models are available for intra- and inter-individual variations, homoscedastic, proportional or multiplicative error model. For each analysis, the program outputs the ELS function, the Akaikeís information criterion (for rapid comparison between models), the parameters and variabilities estimates, the listing of all time-courses with observed and calculated dependent variables. Graphical representations are immediately available, kinetic plots, residual plots and residual versus covariate plots. A number of tool commands allow to get covariates statistics, mean and individual pharmacokinetic parameters according to covariate values, and non compartmental and compartmental mean parameters. The importation of NM-TRAN formatted files is possible.
Reference: PAGE 5 (1996) Abstr 574 [www.page-meeting.org/?abstract=574]
Poster: poster