Thursday 16 October, 2025
Objectives: To introduce methods for constructing informative priors from historical data or by elicitation from experts To discuss different methods…
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Some considerations concerning covariates in clinical trials
Thursday 16 October, 2025
The closer you get to registration in drug development, the greater the resistance to using covariate information. There is a…
Read moreImplementing Receptor Theory in PK-PD Modeling
Thursday 16 October, 2025
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models differ from conventional PK-PD models in that they quantitatively characterize specific processes on the causal path…
Read moreValidation of statistically reliable biomarkers
Thursday 16 October, 2025
DefinitionsBiomarkers play an increasing role in the development of new cancer treatments. A biomarker is defined as "a characteristic that…
Read moreHandling within-subject/between-occasion variability in longitudinal data: Common Challenges and Practical Solutions
Thursday 16 October, 2025
One of the main features of nonlinear mixed-effects models (NLME), and arguably the most powerful one, is their ability to…
Read moreMixed models for the analysis of categorical repeated measures
Thursday 16 October, 2025
PDF of presentation Whenever a response is measured repeatedly within a set of units (study-participants, animals, patients, …)Â correct statistical…
Read moreA Tutorial on Visual Predictive Checks
Thursday 16 October, 2025
The visual predictive check (VPC) is a model diagnostic that can be used to: (i) allow comparison between alternative models,…
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