Thursday 16 October, 2025
Background: Unintentional weight loss is a symptom of serious disease or illness. Two widely recognized, yet, under diagnosed diseases that…
Read morePoster: Real-world data (RWD) in pharmacometrics
A semi-systematic review on the maturational physiology in exclusively breastfed infants: Growth – A contribution from the ConcePTION project
Thursday 16 October, 2025
Introduction: Physiologically-based pharmacokinetic (PBPK) models are a mechanistic model to predict pharmacokinetics (PK) based on study design and medicine- and…
Read moreExploration of CPRD and Yellow Card real-world data to support efficacy and safety targets for levonorgestrel contraceptives.
Thursday 16 October, 2025
Introduction: Failure of contraception is uncommon but inconsistent use is a significant cause of unintended pregnancies. Short-acting contraceptives rely on…
Read moreAging-related CYP3A functional changes: Novel findings from a model-based assessment of real-world pharmacokinetic study in Chinese older inpatients
Thursday 16 October, 2025
Introduction: The conventional wisdom holds that oxidative CYP-mediated clearance would decrease with age, but some recent clinical trials refuted such…
Read moreA case study of applying machine learning to improve non-invasive assessment of fibrosis stage in MASLD
Thursday 16 October, 2025
Introduction Metabolic dysfunction-associated steatohepatitis (MASH), the more severe form of metabolic dysfunction-associated steatotic liver disease (MASLD), is a major cause…
Read morePopulation repeated time-to-event analysis of peritonitis in end-stage renal failure: Predicting the natural progression and infection risk through nationwide registry data
Thursday 16 October, 2025
BACKGROUND Peritonitis is a major complication of peritoneal dialysis (PD)[1]. Despite recent progress in PD product safety, studies still showed…
Read morePopPK-PD modelling of Carboplatin-induced myelosuppression to support therapeutic drug monitoring and dose individualization in cancer patients using Electronic Health Record Data
Thursday 16 October, 2025
Background: Carboplatin is a cytotoxic anticancer drug used in monotherapy or in combination with other chemotherapeutics and/or immunotherapies to treat…
Read moreAn integrative translational framework for in vitro modelling for macozinone to support prediction of early human anti-tubercular efficacy
Thursday 16 October, 2025
Introduction/Objectives: Macozinone (PBTZ169) is a new drug candidate with novel mechanism of action for treatment of tuberculosis. This compound has…
Read moreDose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled ?9-Tetrahydrocannabinol (THC) Cannabis Market Products in Occasional and Daily Users
Thursday 16 October, 2025
Introduction: Estimating THC exposure is key to examining the public health implications of cannabis consumption.[1] Cannabis legalization has increased the…
Read moreAnemia control under maintenance hemodialysis (HD) and association with long-term outcome in pediatric and adolescent patients – a real-world data analysis
Thursday 16 October, 2025
Objectives: Renal anemia is an important complication in hemodialysis (HD) patients requiring erythropoiesis stimulating agents (ESA) in about 90% of…
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