Thursday 16 October, 2025
Objectives: Time dependent parameters are sometimes required to describe the pharmacokinetics of a drug. NONMEM provides the user with a…
Read morePoster: Other topics - Methodology
A Negative feedback model for a mechanism based description of longitudinal observations: application for bone turnover biomarkers.
Thursday 16 October, 2025
Objectives: In modern medicine the initial diagnosis of an abnormal metabolic condition is based on blood borne measurements often involving multiple…
Read moreModeling of renal failure, dialysis, inhalation and mechanical ventilation: Development of a whole-body physiologically-based pharmacokinetic (PBPK) model for ICU patients with and without renal failure receiving inhalatively administered Amikacin via a tracheal tube.
Thursday 16 October, 2025
Objectives: Aim of this study was to establish a whole-body PBPK model for inhalative administration of Amikacin to renally impaired…
Read moreComparison of methods for handling missing covariate data
Thursday 16 October, 2025
Background: Inclusion of important covariates in non-linear mixed effects modelling will reduce the unexplained inter-individual variability and improve the predictability…
Read moreUtilising prior literature population models to inform clinical practice – a dosing regimen for immediate N-acetyl cysteine treatment of paracetamol overdose
Thursday 16 October, 2025
Objectives: This research shows how a model from a prior population analysis can be used with clinical trial simulations to…
Read moreModeling Pain score in clinical trials using a joint survival-longitudinal mixed model with a Beta distribution in presence of missing values not occurring at random.
Thursday 16 October, 2025
Objectives: In clinical trials investigating pain drugs, the pain is usually assessed by means of a score or a Visual…
Read moreDrug Effects on Sleep Data from a 28-Day Clinical Study in Insomniac Patients: Covariate Analysis Using a Multinomial Mixed-Effect Markov-Chain Model
Thursday 16 October, 2025
Objectives: Sleep quality is objectively assessed through polysomnography (PSG), from which clinical efficacy endpoints like sleep latency (LPS) or wake…
Read moreKinetic nomograms assist individualization of drug regimens
Thursday 16 October, 2025
Objective: The aim of this work is to propose a rapid and simple drug dosage adjustment method. Develop a useful…
Read morePK/PD Model of skin toxicity in animal reported as binary outcome
Thursday 16 October, 2025
Objectives: Develop a PK/PD model for skin toxicity in animal and provide a quantitative basis for preclinical safety assessment. Material…
Read moreEvaluating Bootstrap Methods in Nonlinear Mixed Effect Models (NMEM) Using a PK Model
Thursday 16 October, 2025
Objectives: The bootstrap methods in PK/PD studies have not investigated the bias and reliability of various bootstrap confidence interval (CI)…
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