Thursday 16 October, 2025
Objectives: This study aimed to modify the Bland-Altman method which is used for evaluating agreement between two measurement techniques with…
Read morePoster: Other Modelling Applications
Longitudinal Modelling of FEV1 Effect of Bronchodilators
Thursday 16 October, 2025
Objectives: Understanding the bronchodilatory potential and dose response profile early in the development programme is important for informing future investment…
Read moreBenchmarking therapeutic drug monitoring software: A systematic evaluation of available computer tools
Thursday 16 October, 2025
Objectives: Therapeutic drug monitoring (TDM) aims at optimizing treatment by individualizing dosage regimen based on blood concentrations measurement. Maintaining concentrations…
Read morePopulation Pharmacokinetics of Two Volatile Markers Used for Assessment of Definitive Adherence
Thursday 16 October, 2025
Objectives: The availability of a breath test to measure medication adherence in real-time, either at home or in a clinic,…
Read moreInfluence of a priori information, designs and undetectable data on individual parameters estimation and prediction of hepatitis C treatment outcome
Thursday 16 October, 2025
Objectives: Viral kinetics analysis based on nonlinear mixed effect models is a useful tool for individualized hepatitis C virus (HCV)…
Read moreA systems approach to predicting differences in pharmacological response to a CYP1A2 substrate, resulting from pharmacokinetic differences in non-smokers, passive smokers and heavy smokers
Thursday 16 October, 2025
Objectives: Induction of CYP1A2 by cigarette smoke is well established. A recent report suggests the possibility of predicting consequential pharmacokinetic…
Read morePrediction of Rosiglitazone compliance from last sampling information using Population based PBPK modelling and Bayes theorem: Comparison of prior distributions for compliance.
Thursday 16 October, 2025
Objectives: To predict the compliance scenario of Rosiglitazone from a patient's last PK sampling point and to compare the predictive…
Read moreMixed effect modeling of neuronal cell differentiation kinetics from longitudinal phase-contrast imaging data
Thursday 16 October, 2025
Objectives: Neuronal cell fate decisions are an active field of research and the detection of the cell phenotype differentiation, i.e….
Read moreOxymorphone PKPD relationship and blood-brain barrier transport studied with microdialysis
Thursday 16 October, 2025
Objectives: This study aimed to characterize the BBB transport and pharmacokinetic and pharmacodynamic (PKPD) relationship of oxymorphone in rats using…
Read moreBioequivalence evaluation using population modeling method
Thursday 16 October, 2025
Objectives: In general bioequivalence (BE) study is conducted in healthy volunteers with serial dense blood sampling for pharmacokinetics (PK). However,…
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