Thursday 16 October, 2025
Objectives: To evaluate efficiency gain of the two parallel computing methods in resolving complicated popPK and popPK/PD models. Methods: Subjects from…
Read morePoster: Other Modelling Applications
Modeling and Simulation to Probe the Likely Difference in Pharmacokinetic Disposition of R- and S-Enantiomers Justifying the Development of Racemate Pomalidomide
Thursday 16 October, 2025
Introduction: Pomalidomide is a immunomodulatory drug with pleiotropic actions of cytotoxity against multiple myeloma cells, immunomodulatory and anti-angiogenic activity, that…
Read morePopulation analysis of paraquat toxicokinetics in poisoning patients
Thursday 16 October, 2025
Objectives: Paraquat (PQ) is a commonly used herbicide that has caused many accidental or intentional deaths. Only a few studies…
Read morePredictive Modelling Environment – Infrastructure and functionality for pharmacometric activities in R&D
Thursday 16 October, 2025
Objectives: The Predictive Modelling Environment (PME) supports Clinical Pharmacology Modelling & Simulation, enabling the implementation of M&S activities which are…
Read moreSimulation of the effect of hyperhydration on urine levels of recombinant human erythropoietin from a doping control point of view
Thursday 16 October, 2025
Objectives: To study the effect of hyperhydration on the urine pharmacokinetic profile of recombinant human erythropoietin (rHuEPO) and its possible…
Read moreSemi-mechanistic population PKPD modelling of a surrogate biomarker
Thursday 16 October, 2025
Objectives: To develop through a sequential approach a single PKPD model of a surrogate biomarker SB as a function of…
Read moreStochastic Simulations Assist to Select the Intravenous Digoxin Dosing Protocol in Elderly Patients in Acute Atrial Fibrillation
Thursday 16 October, 2025
Objective: To select the optimal intravenous (IV) loading dose schedule for digoxin in patients under acute atrial fibrillation (AAF), by…
Read morePopulation pharmacokinetic model characterising the influence of circadian rhythm on the pharmacokinetics of oral and intravenous midazolam in healthy volunteers
Thursday 16 October, 2025
Objectives: Chronopharmacology studies have revealed circadian variability in pharmacokinetics and pharmacodynamics of different drugs. Time-dependent changes may occur for absorption,…
Read moreThe “SBPOP Package”: Efficient Support for Model Based Drug Development – From Mechanistic Models to Complex Trial Simulation
Thursday 16 October, 2025
Objectives: Model-based drug development (MBDD) emphasizes the quantitative integration of relationships among diseases and disease targets, drug characteristics, and individual…
Read moreUsing Stochastic Control Methods and Pharmacokinetics to Individualise Drug Therapy: A Case Study with the Enzyme Inhibitor Imatinib.
Thursday 16 October, 2025
Objectives: The list of drugs which exist in healthcare to treat various conditions and diseases is vast with new drugs…
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