Thursday 16 October, 2025
Objectives: In the 90s and 00s, a dozen compounds were withdrawn from the market because of association with a rare…
Read morePoster: New Modelling Approaches
Predicting in vivo drug response and synergistic combinations from three-dimensional tumour cell cultures
Thursday 16 October, 2025
Objectives: Synergistic combinations of standard-of-care drugs or new chemical or biological entities show much promise in the treatment of cancer,…
Read moreHow Anti-cancer Targeted Therapies Used in Combination Interact? Analysis with a Semi-mechanistic Model of Minimal Signalling Networks
Thursday 16 October, 2025
Objectives: Targeted agents are specific inhibitors of signalling and metabolic pathways used in oncology to counteract tumour proliferation and angiogenesis….
Read morePhysiological modeling of interindividual variability: PBPK-NLME vs. compartimental modeling
Thursday 16 October, 2025
Objectives: The assessment of inter-individual variability is a key aspect in PK modeling which is usually performed using compartmental models…
Read moreThree case studies of pharmacokinetic model building using a multi-objective genetic algorithm
Thursday 16 October, 2025
Objectives: The scope of most manual PK model building searches is constrained by the time and effort associated with model…
Read moreAnalysis of the relationship between Mycophenolic acid (MPA) exposure and anemia using three approaches: logistic regression based on Generalized Linear Mixed Models (GLMM) or on Generalized Estimating Equations (GEE) and Markov mixed-effects model.
Thursday 16 October, 2025
Objectives: The goal of this study was to evaluate the influence of MPA exposure on the occurrence of anemia in…
Read moreJoint model for longitudinal exposure to mycophenolic acid and rejection survival data in the first year after renal transplantation
Thursday 16 October, 2025
Objectives: Previous studies have reported conflicted results concerning the relationships between mycophenolic acid (MPA) exposure and the risk of acute…
Read morePharmML – An Exchange Standard for Models in Pharmacometrics
Thursday 16 October, 2025
Objectives: A long-standing problem in Pharmacometrics is the lack of a common standard allowing for exchangeability of models between existing…
Read moreMultimodal Physiologically-Based Modelling and Analysis of Kinetics of Drug-Delivery with Modular Nanotransporters (MNT)
Thursday 16 October, 2025
Objectives: The modular nanotransporters (MNT), a recombinant multidomain protein, used for delivery of various cytotoxic agents (radioisotopes, photosensitizers) to solid…
Read moreApplication of the SBTOOLBOX2 in drug discovery and development
Thursday 16 October, 2025
Objectives: In modern Drug discovery and Development, mechanistic physiologically based and more traditional PKPD models all play an important role….
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